High fructose-enriched diet synergistically exacerbates endocrine but not metabolic changes in letrozole-induced polycystic ovarian syndrome in Wistar rats

Akintayo, Christopher O.; Johnson, Anjola D.; Badejogbin, Olabimpe C.; Olaniyi, Kehinde S.; Oniyide, Adesola A.; Ajadi, Isaac O.; Ojewale, A.O.; Adeyomoye, Olorunsola; Kayode, Adedeji B.

doi:10.1016/j.heliyon.2020.e05890

Cited by 12 publications

(7 citation statements)

References 29 publications

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“…In women with PCOS, low-GI meals lowered ghrelin while increasing glucagon [ 47 ]. High fructose consumption (HFC) exacerbated endocrine but not metabolic alterations in PCOS, implying that HFC may worsen endocrine-related phenotypes in PCOS [ 48 ]. A meta-analysis and systematic review concluded that an LGI diet is an effective, acceptable, and safe intervention for IR relief, and that professional dietary counselling should be provided to all PCOS patients [ 49 , 50 ].…”

Section: Causes and Risk Factorsmentioning

confidence: 99%

Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics

Singh¹,

Pal²,

Shubham³

et al. 2023

JCM

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Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Lifestyle or diet, environmental pollutants, genetics, gut dysbiosis, neuroendocrine alterations, and obesity are among the risk factors that predispose females to PCOS. These factors might contribute to upsurging metabolic syndrome by causing hyperinsulinemia, oxidative stress, hyperandrogenism, impaired folliculogenesis, and irregular menstrual cycles. Dysbiosis of gut microbiota may play a pathogenic role in the development of PCOS. The restoration of gut microbiota by probiotics, prebiotics, or a fecal microbiota transplant (FMT) might serve as an innovative, efficient, and noninvasive way to prevent and mitigate PCOS. This review deliberates on the variety of risk factors potentially involved in the etiology, prevalence, and modulation of PCOS, in addition to plausible therapeutic interventions, including miRNA therapy and the eubiosis of gut microbiota, that may help treat and manage PCOS.

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Section: Causes and Risk Factorsmentioning

confidence: 99%

Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics

Singh¹,

Pal²,

Shubham³

et al. 2023

JCM

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“…52 In addition, rats with letrozole-induced PCOS had higher body weights, which were comparable to those seen in women with PCOS. 49 Furthermore, rats with PCOS had an extended diestrus phase and did not have a regular estrus cycle. 53 which corroborate our findings in this study, since the reduction in the frequency of estrous cycles in PCOS rats resulting in anovulation which occurs at an early stage of pro-estrous to the end of oestrus, 54 leading to female infertility.…”

Section: Discussionmentioning

confidence: 99%

“…Increased body and ovarian weight support the report of. 48,49,51 The increase in body and ovarian weight is attributed to abdominal fat deposits and thickening of ovarian capsules, and hyperplasia of theca internal cells in the ovary. Also, increased body and ovarian weight may be connected to letrozole’s anabolic characteristics, which have been linked to fat accumulation and the formation of multiple cysts in the ovary, respectively.…”

Section: Discussionmentioning

confidence: 99%

Histomorphometric and biochemical activities of bioactive component of Cyperus esculentus tubers extract on letrozole-induced polycystic ovarian syndrome and cholesterol homeostasis in female Sprague-Dawley rats

Adelakun

Ojewale

Jeje

et al. 2022

Toxicology Research and Application

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Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder, causes irregular menstrual cycles, dyslipidemia, excessive body weight, oxidative stress, hyperandrogenism, and infertility. This study focused on the impact of Cyperus esculentus (CES) on letrozole-induced PCOS in female Sprague-Dawley rats. Twenty (20) normal rats and twenty (20) PCOS rats (150–200 g, 8 weeks old) were randomly divided into four groups of ten ( n = 10) rats each. Group A served as normal control group received 2 mL of normal saline, group B treated with 500 mg/kg body weight of CES , group C PCOS control group received 2 mL of normal saline, and group D PCOS rats post-treated with 500 mg/kg body weight of CES daily through gastric gavage for 30 days. Estrus cyclicity, body and ovaries weights, biochemical and histological parameters were measured. Observed irregular estrus cyclicity and multiple cysts in PCOS rats, increase glycemia, ovarian weight, triglycerides, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, malondialdehyde, luteinizing hormone (LH), testosterone, and decrease high-density lipoprotein cholesterol, estradiol, progesterone, catalase, reduced glutathione (GSH), and superoxide dismutase levels, compared with control. The intervention of CES ameliorated and restored the estrus cyclicity reproductive hormone, biochemical, and structural alterations. Moreover, CES significantly decreased cystic follicles, LH, and testosterone levels, but increased estradiol concentration. This plant may be beneficial in the management and treatment of PCOS-related reproductive and metabolic disorders.

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“…A study demonstrated that high-fructose corn syrup feeding for 28 days has adverse effects in adult female rats with changes in the length of the estrous cycle as well as ovarian and uterine histology [ 241 ]. Furthermore, high-fructose consumption caused an increase in ovarian weight, testosterone, and luteinising hormone level, and also a decrease in follicle-stimulating hormone in rats with the letrozole-induced polycystic ovarian syndrome [ 242 ]. Polycystic ovary syndrome is one of the most common endocrine disorders observed in premenopausal women leading to ovarian dysfunction.…”

Section: The Impact Of Fructose On Reproductive Functionmentioning

confidence: 99%

The impact of dietary fructose on gut permeability, microbiota, abdominal adiposity, insulin signaling and reproductive function

Güney¹,

Bal²,

Akar³

2023

Heliyon

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High fructose-enriched diet synergistically exacerbates endocrine but not metabolic changes in letrozole-induced polycystic ovarian syndrome in Wistar rats

Cited by 12 publications

References 29 publications

Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics

Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics

Histomorphometric and biochemical activities of bioactive component of Cyperus esculentus tubers extract on letrozole-induced polycystic ovarian syndrome and cholesterol homeostasis in female Sprague-Dawley rats

The impact of dietary fructose on gut permeability, microbiota, abdominal adiposity, insulin signaling and reproductive function

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