High frequency of adverse health behaviors in multiple sclerosis

Marrie, Ruth Ann; Horwitz, Ralph I.; Cutter, Gary; Tyry, Tuula; Campagnolo, Denise I.; Vollmer, Tim

doi:10.1177/1352458508096680

Cited by 129 publications

(100 citation statements)

References 41 publications

(53 reference statements)

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“…26 Smoking can also be associated with other comorbidities and with other environmental risk factors for MS, such as increased anti-Epstein-Barr virus antibodies. 26,27 Our exclusion criteria consisted of conditions that may influence quantitative MRI analysis, including cerebrovascular disease and positive history of alcohol abuse. However, we did not obtain data on other comorbidities, such as obesity, hypertriglyceridemia, and hypertension.…”

Section: Global and Central Atrophy Measuresmentioning

confidence: 99%

Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis

et al. 2009

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Section: Global and Central Atrophy Measuresmentioning

confidence: 99%

Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis

et al. 2009

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“…Indeed, persons with MS have similar rates of overweight and obesity as the general population [24,25], and this is problematic given the rates in the general population of adults [26]. For example, one study reported an average BMI of 27.0 kg/ m 2 in a large sample of persons with MS (n=8983); this average BMI value is comparable with the general population, but suggests that many persons with MS are overweight [25]. Another study of 123 women with MS reported that participants had higher BMI, waist circumference, and total body fat percentage than recommended by the World Health Organization [26] One limitation of previous research on deconditioning in persons with MS is that the studies measured single domains of physical fitness.…”

mentioning

confidence: 99%

The Importance of Physical Fitness in Multiple Sclerosis

Motl¹

2013

J Nov Physiother

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Multiple Sclerosis (MS) is a common and life-altering neurological disease among adults in the United States and worldwide. This disease has an estimated prevalence of 1 per 1,000 adults in the United States [1] with the majority of cases occurring in women of European descent. The MS pathophysiology initially involves episodic periods of immune-mediated demyelination and transection of axons within the Central Nervous System (CNS). This results in the disruption of saltatory conduction of action potentials along myelinated axonal pathways in the brain, spinal cord, and optic nerves. The MS pathophysiology later transitions into a neurodegenerative disease process, presumably associated with insufficient neurotrophic support, and results in the accumulation of irreversible neurologic disability. The degree and location of axonal and neuronal damage within the CNS result in the heterogeneous expression of symptomatic, functional, and participatory consequences among persons with MS [2]. Such manifestations might be initiated or worsened by physical inactivity and resulting physiological deconditioning.We have previously described a model of physical inactivity, deconditioning, and worsening MS [3,4], and this was based on a similar framework for persons with chronic disease conditions [5] including MS [6]. The model is displayed in figure 1 and indicates that MS onset results in physical inactivity [7,8] that initiates physiological deconditioning (i.e., compromised or reduced physical fitness). This physiological deconditioning, in turn, results in worsening of MS, as indicated by loss of brain structure and function as well as symptomatic (e.g., fatigue) and functional (e.g., walking impairment) manifestations. The worsening of MS results in further physical inactivity and subsequent physiological deconditioning thereby yields a cycle of associations among physical inactivity, deconditioning, and worsening MS that develops over time. This model is important as it conceptualizes the importance of maintaining and improving physical fitness levels in persons with MS. Physical fitness might provide a form of "physiological reserve" that is protective of disease consequences and worsening of MS and this is consistent with other literatures such as cancer [9].To that end, this paper provides a comprehensive review of research on physical fitness in persons with MS. We begin by defining physical fitness and its domains as well as differentiating it from physical activity. We then present research on physiological deconditioning (i.e., detraining that manifests as a reduction in domains of physical work capacity or fitness) in persons with MS as well as evidence on the association between markers of physical fitness and consequences of MS. We lastly review research regarding the effects of exercise training on physical fitness and consequences of MS, and conclude with recently developed exercise recommendations for improving physical fitness. Our goal is the provision of a paper that underscores the (a) importance of p...

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“…These comorbid medical conditions, or the medications used to treat them, may have effects on the unborn child. Lifestyle factors such as smoking, alcohol intake, exercise and obesity may also play a role; for example, there is evidence that individuals with MS may be more likely to engage in behaviors that are known to be harmful to developing fetuses including smoking and alcohol consumption [42]. These potential confounders should be considered in any analysis of birth outcomes of individuals with MS.…”

Section: Potential Confounding Factorsmentioning

confidence: 99%

Safety of disease-modifying drugs for multiple sclerosis in pregnancy: current challenges and future considerations for effective pharmacovigilance

Wang

Guimond

et al. 2013

Expert Review of Neurotherapeutics

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High frequency of adverse health behaviors in multiple sclerosis

Abstract: Patients with MS exhibit frequent adverse health behaviors, increasing the risk of other chronic diseases. Further research is needed to determine how these behaviors influence disability progression, quality of life, and other MS-related outcomes.

Cited by 129 publications

References 41 publications

Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis

Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis

The Importance of Physical Fitness in Multiple Sclerosis

Safety of disease-modifying drugs for multiple sclerosis in pregnancy: current challenges and future considerations for effective pharmacovigilance

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