High‐frequency (20 MHz) high‐intensity focused ultrasound: New Treatment of actinic keratosis, basal cell carcinoma, and Kaposi sarcoma. An open‐label exploratory study

Serup, Jørgen; Bove, Torsten; Zawada, Tomasz; Jessen, Alexander; Poli, Mattia

doi:10.1111/srt.12883

Cited by 21 publications

(40 citation statements)

References 15 publications

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“…It is noteworthy and clearly an advantage relative to other methods, except carbon dioxide lasers, that only one treatment was needed. The level of pain was significant, and however, a lower pain level was found in other studies of other anatomical sites than the hands having many sensory nerves [ 12 , 15 ].…”

Section: Discussion/conclusionmentioning

confidence: 67%

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Removal of Common Warts by High-Intensity Focused Ultrasound: An Introductory Observation

Bove¹,

Zawada²,

Jessen³

et al. 2021

Case Rep Dermatol

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Therapies of common warts are cumbersome and not very effective. Recurrences are common. A new 20 MHz high-intensity focused ultrasound (HIFU) method is introduced as a new potential treatment modality. With HIFU, selected targets in the epidermis and dermis can be treated with full control of the depth and position of the ultrasound lesion and the energy applied to the target. The treatment can be monitored directly in real-time via an integrated dermoscope in the ultrasound probe. Two warts were treated with 8–10 shoulder-by-shoulder treatment doses, focal depth 1.3 mm, and 1.2 J/dose. Pretreatment ultrasound B-mode scanning had shown the thickness and depth of the warts. The treated areas developed a dry wound covered by a crust over the next 1–2 days. After 2 weeks the skin was healed, with no wart and no scar. Observation showed no reoccurrence. HIFU has future potential for treatment of common warts and flat warts, and a broad range of skin lesions being logic further candidates for targeted ablative treatment. One single treatment may suffice. It is, therefore, a new modality in dermatology with a large range of indications.

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Section: Discussion/conclusionmentioning

confidence: 67%

“…HIFU was concluded safe and relevant for different dermatological indications [ 6 , 11 ]. Actinic keratosis, basal cell carcinoma, and Kaposi Sarcoma were treated successfully [ 12 ]. The case presented is the first application of dermatological 20 MHz HIFU to common warts located on the hand.…”

Section: Introductionmentioning

confidence: 99%

Removal of Common Warts by High-Intensity Focused Ultrasound: An Introductory Observation

Bove¹,

Zawada²,

Jessen³

et al. 2021

Case Rep Dermatol

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“…The 20 MHz HIFU system used in the present study has recently been successfully introduced to actinic keratosis and selected cases of basal cell carcinoma and Kaposi sarcoma. 28 The HIFU treatment, as found in the study of pigs, was often followed by a wheal and flare response that peaked after 5-10 minutes and faded over the subsequent 10-30 minutes. After a few days a superficial dry wound and inflammatory reaction in the treated area was observed, followed by the necrotic material being expelled from the skin leaving an excavated inflamed wound that healed gradually.…”

Section: F I G U R E 1 Schematic Illustration Of the High-intensitymentioning

confidence: 87%

“…Comparison of lasers versus HIFU has the following high- Twenty megahertz HIFU was recently documented effective in the treatment of actinic keratosis, with a cure rate of 97%. 28 HIFU was found to be well-suited for field eradication and has the potential to replace or supplement photodynamic therapy. HIFU was also applied to skin cancers.…”

Section: Discussionmentioning

confidence: 99%

High‐frequency (20 MHz) high‐intensity focused ultrasound: New ablative method for color‐independent tattoo removal in 1‐3 sessions. An open‐label exploratory study

Serup

Bove²,

Zawada³

et al. 2020

Skin Research and Technology

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“…Compared to low-frequency ultrasound, high-frequency focused ultrasound has better targeting precision due to its smaller focal volume. For example, 20-MHz HIFU transducers with small depth of focus (1.1–1.7 mm) have been used in a recent clinical study to treat early-stage actinic keratosis (AK) and skin cancers, where the diameter (2–3 mm) and thickness (1–2 mm) of the tumors are small, achieving a cure rate of 97% [ 26 ]. However, since the treatment relies on HIFU-induced heat, it causes pain and inflammation, and is essentially non-selective.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Non-Thermal, Selective Cancer Treatment With High-Frequency Medium-Intensity Focused Ultrasound

Tang¹,

Chen

Zhang

et al. 2021

IEEE Access

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Focused ultrasound (FUS) has proven its efficacy in non-invasive, radiation-free cancer treatment. However, the commonly used low-frequency high intensity focused ultrasound (HIFU) destroys both cancerous and healthy tissues non-specifically through extreme heat and inertial cavitation with low spatial resolution. To address this issue, we evaluate the therapeutic effects of pulsed (60 Hz pulse repetition frequency, 1.45 ms pulse width) high-frequency (20.7 MHz) medium-intensity (spatial-peak pulse-average intensity ISPPA < 279.1 W/cm , spatial-peak temporal-average intensity ISPTA < 24.3 W/cm 2 ) focused ultrasound (pHFMIFU) for selective cancer treatment without thermal damage and with low risk of inertial cavitation (mechanical index < 0.66), in an in vivo subcutaneous B16F10 melanoma tumor growth model in mice. The pHFMIFU with 104 μm focal diameter is generated by a microfabricated self-focusing acoustic transducer (SFAT) with a Fresnel acoustic lens. A three-axis positioning system has been developed for automatic scanning of the transducer to cover a larger treatment volume, while a water-cooling system is custom-built for dissipating non-acoustic heat from the transducer surface. Initial testing revealed that pHFMIFU treatment can be applied to a living animal while maintaining skin temperature under 35.6 °C without damaging normal skin and tissue. After eleven days of treatment with pHFMIFU, the treated tumors were significantly smaller with large areas of necrosis and apoptosis in the treatment field compared to untreated controls. Potential mechanisms of this selective, non-thermal killing effect, as well as possible causes of and solutions to the variation in treatment results, have been analyzed and proposed. The pHFMIFU could potentially be used as a new therapeutic modality for safer cancer treatment especially in critical body regions, due to its cancer-specific effects and high spatial resolution.INDEX TERMS High-frequency focused ultrasound, in vivo experiment, non-invasive therapy, selective cancer treatment, self-focusing acoustic transducers (SFAT), ultrasound therapy. * The average density of soft tissues [37] ** From measurement (described in Appendix B) *** Used the values for water [38] due to similar acoustic properties

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High‐frequency (20 MHz) high‐intensity focused ultrasound: New Treatment of actinic keratosis, basal cell carcinoma, and Kaposi sarcoma. An open‐label exploratory study

Cited by 21 publications

References 15 publications

Removal of Common Warts by High-Intensity Focused Ultrasound: An Introductory Observation

Removal of Common Warts by High-Intensity Focused Ultrasound: An Introductory Observation

High‐frequency (20 MHz) high‐intensity focused ultrasound: New ablative method for color‐independent tattoo removal in 1‐3 sessions. An open‐label exploratory study

In Vivo Non-Thermal, Selective Cancer Treatment With High-Frequency Medium-Intensity Focused Ultrasound

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