High fidelity tonotopic mapping using swept source functional magnetic resonance imaging

Cheung, Matthew M.; Lau, Condon; Zhou, Iris Y.; Chan, Kevin C.; Zhang, Jevin W.; Fan, Shujuan; Wu, Ed X.

doi:10.1016/j.neuroimage.2012.03.031

Cited by 27 publications

(48 citation statements)

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“…The different types of cells represented within the central nucleus (each characterised by distinct electrophysiological properties and discharge patterns) enable highly precise representation of complex auditory signals (Peruzzi et al, 2000). Animal studies have shown that the central nucleus receives ascending (bottomeup) projections from various brainstem nuclei (summarised in Baumann et al, 2011) e including the dorsal and posterior ventral cochlear nucleus (Warr, 1969;Oliver, 1984) e and is tonotopically organised along the dorsoeventral axis (Schreiner and Langner, 1997;Malmierca et al, 2008;Baumann et al, 2011;Cheung et al, 2012). Evidence for a tonotopic organisation within the central nucleus has been found in humans as well, where high-resolution functional magnetic resonance imaging has identified a dorsolateral-to-ventromedial gradient preferentially responding to low-to-high frequencies (De Martino et al, 2013).…”

Section: Inferior Colliculusmentioning

confidence: 99%

Subcortical processing in auditory communication

2015

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a b s t r a c tThe voice is a rich source of information, which the human brain has evolved to decode and interpret. Empirical observations have shown that the human auditory system is especially sensitive to the human voice, and that activity within the voice-sensitive regions of the primary and secondary auditory cortex is modulated by the emotional quality of the vocal signal, and may therefore subserve, with frontal regions, the cognitive ability to correctly identify the speaker's affective state. So far, the network involved in the processing of vocal affect has been mainly characterised at the cortical level. However, anatomical and functional evidence suggests that acoustic information relevant to the affective quality of the auditory signal might be processed prior to the auditory cortex.Here we review the animal and human literature on the main subcortical structures along the auditory pathway, and propose a model whereby the distinction between different types of vocal affect in auditory communication begins at very early stages of auditory processing, and relies on the analysis of individual acoustic features of the sound signal. We further suggest that this early feature-based decoding occurs at a subcortical level along the ascending auditory pathway, and provides a preliminary coarse (but fast) characterisation of the affective quality of the auditory signal before the more refined (but slower) cortical processing is completed.

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Section: Inferior Colliculusmentioning

confidence: 99%

Subcortical processing in auditory communication

2015

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“…Animals were prepared for fMRI experiments as described in our previous studies (Chan et al, 2010;Cheung et al, 2012aCheung et al, , 2012bGao et al, 2014;Lau et al, 2011Lau et al, , 2013Lau et al, , 2015Zhang et al, 2013;Zhou et al, 2012Zhou et al, , 2014. Briefly, male Sprague-Dawley rats (300-350 g, N = 10) were used in this study.…”

Section: Animal Preparationmentioning

confidence: 99%

“…Recent development in BOLD fMRI has been demonstrated for studying the rodent auditory system (Cheung et al, 2012a(Cheung et al, , 2012bGao et al, 2014;Lau et al, 2013Lau et al, , 2015Yu et al, 2009;Zhang et al, 2013), along with previous auditory fMRI studies conducted on humans (Barton et al, 2012;De Martino et al, 2013;Sigalovsky and Melcher, 2006), primates (Baumann et al, 2011;Kayser et al, 2007;Tanji et al, 2010) and songbirds (Boumans et al, 2007;Van Meir et al, 2005;Voss et al, 2007).…”

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confidence: 99%

“…In mouse IC, neurons with CF higher than 60 kHz are rarely found and occupy a very small tonotopic area compared to those with lower CFs (Stiebler and Ehret, 1985;Yu et al, 2005). Similarly, in rat IC, representations of frequencies higher than 40 kHz are seldom delineated (Cheung et al, 2012a(Cheung et al, , 2012bMalmierca et al, 2008). This mismatch immediately poses a basic question how UHFs are encoded in the auditory system of these species.…”

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confidence: 99%

“…For example, in the primary auditory nucleus in the midbrain, called the inferior colliculus (IC), which is a compulsory relay for all ascending auditory projections (Malmierca, 2003) and a region that efficiently encodes vocalizations (Holmstrom et al, 2010), the tonotopic organization is a basic feature in its central nucleus (CNIC), where the CFs of neurons run from low to high along the dorsolateralventromedial dimension (Cheung et al, 2012a(Cheung et al, , 2012bDe Martino et al, 2013;Malmierca et al, 2008;Ress and Chandrasekaran, 2013;Schreiner and Langner, 1997;Yu et al, 2005). In the cortical regions of the IC, the frequency organization is usually non-tonotopic, with neurons showing complex frequency tuning properties, such as broadband or multipeak receptive fields (Duque et al, 2012;Hernandez et al, 2005;Malmierca et al, 2011;Stebbings et al, 2014).…”

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confidence: 99%

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BOLD fMRI study of ultrahigh frequency encoding in the inferior colliculus

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Evaluation of microvasculature at the auditory midbrain–the benefits of sectioning at a tangential angle

Hsing

et al. 2014

Microscopy Res & Technique

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Vascular remodeling in the brain occurs as a plastic change following neural over-activity. The auditory midbrain (or inferior colliculus, IC) is an ideal place to study sound-induced vascular changes because it is the brain's most vascularized structure and it is tonotopically organized. However, its micro-vascular pattern remains poorly understood. Since the IC is a sphere-like structure, the histological assessment of vasculature could depend on the angle of sectioning. Here, we studied the effects of cutting the IC at different angles on microvascular assessment, specifically: micro-vascular density and the shape of microvascular lumen. Photomicrographs were taken from 5 µm toluidine blue-stained histological sections obtained at two angles of sectioning: (a) the conventional coronal sectioning, and (b) a novel "tangential" sectioning (tangential to the dorso-medial surface of the IC). Results showed that the tangential sections, in comparison with the coronal sections, yielded (a) a higher count of micro-vascular density and (b) a higher proportion of round-shaped micro-vascular lumens. This discrepancy in results between two cut angles is likely related to the spatial pattern of blood vessels supplying the IC. We propose that the tangential sectioning should be adopted as standard for the accurate study of microvasculature in the IC.

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High fidelity tonotopic mapping using swept source functional magnetic resonance imaging

Cited by 27 publications

References 50 publications

Subcortical processing in auditory communication

Subcortical processing in auditory communication

BOLD fMRI study of ultrahigh frequency encoding in the inferior colliculus

Evaluation of microvasculature at the auditory midbrain–the benefits of sectioning at a tangential angle

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