2002
DOI: 10.3168/jds.s0022-0302(02)74370-1
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Abstract: Increased liver blood flow (LBF) resulting from elevated feed intake in lactating dairy cows may increase steroid metabolism. Continuous infusion of bromosulphthalein (BSP; specifically metabolized in liver) was used to measure LBF. Similarly, progesterone (P4) and estradiol-17beta (E2) were administered by continuous infusion. Circulating concentrations at steady state were used to calculate the metabolic clearance rate (MCR) of BSP, P4, and E2. Experiment 1: Variation in LBF was determined in thee nonlactati… Show more

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Cited by 509 publications
(429 citation statements)
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“…In addition, these studies demonstrated that the reduced P4 concentrations caused by overfeeding produced the reduction in fertility in overfed ewes (Parr et al, 1987). Our results extended the results from previous studies to the lactating dairy cow and clearly demonstrated the relationship between dry matter intake, liver blood flow, and circulating concentrations of P4 (Sangsritavong, 2002;Sangsritavong et al, 2002;Vasconcelos et al, 2003;Wiltbank et al, 2006).…”
Section: Factors Regulating Circulating P4 Concentrationssupporting
confidence: 87%
See 1 more Smart Citation
“…In addition, these studies demonstrated that the reduced P4 concentrations caused by overfeeding produced the reduction in fertility in overfed ewes (Parr et al, 1987). Our results extended the results from previous studies to the lactating dairy cow and clearly demonstrated the relationship between dry matter intake, liver blood flow, and circulating concentrations of P4 (Sangsritavong, 2002;Sangsritavong et al, 2002;Vasconcelos et al, 2003;Wiltbank et al, 2006).…”
Section: Factors Regulating Circulating P4 Concentrationssupporting
confidence: 87%
“…Primary regulation of P4 metabolism is due to changes in blood flow to the liver . For example, if liver blood flow increased from 1000 to 2000 l/h then circulating P4 concentrations will decrease to 50% even though P4 production and P4 metabolizing enzymes have not changed (Sangsritavong et al, 2002;Wiltbank et al, 2006 and. The role of feed intake in regulating liver blood flow, P4 metabolism, and circulating P4 was initially demonstrated in studies with pigs and sheep (Christenson et al, 1985;Parr et al, 1993;Prime and Symonds, 1993).…”
mentioning
confidence: 99%
“…Increased feeding is associated with elevated liver blood flow and increased steroid metabolism in lactating cows. Sangsritavong et al (2002) showed that high feed intake increased liver blood flow by 58% by 4 hours after feeding, while cows left unfed during the same period showed an 83% decrease in liver blood flow. They also found that the baseline liver blood flow in lactating cows was over twice that of non-lactating cows, and that lactating cows had lower serum progesterone and oestrogen levels than non-lactating cows.…”
Section: Progesterone and Embryo Lossmentioning
confidence: 95%
“…A reduction in embryo survival rate has also been associated with high energy intake and this has been explained on the basis of an inverse relationship between feed intake and systemic progesterone concentration in sheep (Parr et al, 1987), pigs (Jindal et al, 1996) and cows (Sangsritavong et al, 2002). Increased feeding is associated with elevated liver blood flow and increased steroid metabolism in lactating cows.…”
Section: Progesterone and Embryo Lossmentioning
confidence: 99%
“…Underfeeding can also slow down the metabolic clearance of progesterone (Brockhus et al, 1988;Parr et al, 1993a), an effect that can be rapidly reversed by the resumption of normal intake (Mellor et al, 1987;Oddy and Holst, 1991). The metabolic clearance of progesterone is affected in two ways: (i) a greater rate of catabolism in the liver (Thomford and Dziuk, 1986;Thomas et al, 1987;Sangsritavong et al, 2002); (ii) an increase in hepatic blood flow (Parr, 1992;Parr et al, 1993b;Sangsritavong et al, 2002). About 96% of all progesterone entering the liver and the gut is removed and the breakdown products are excreted in the faeces (Parr et al, 1993b).…”
Section: Mechanism By Which Nutrition Influences Colostrum Productionmentioning
confidence: 99%