High fat-low protein diet induces metabolic alterations and cognitive dysfunction in female rats

Dharavath, Ravinder Naik; Arora, Sangeeta; Bishnoi, Mahendra; Kondepudi, Kanthi Kiran; Chopra, Kanwaljit

doi:10.1007/s11011-019-00459-4

Cited by 17 publications

(11 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MS not only leads to morbidity and mortality, but also costs trillions of dollars due to healthcare expenses and the loss of potential economic activity [4,5]. Approximately 10%-50% of the world's population is suffering from MS, and its prevalence has increased over the past several years [6,7]. MS is the result of interactions between genes, hormones, lifestyle, and the environment; however, the rapid increase in MS is mainly due to shifts in lifestyle and dietary structure to Western patterns, which have been occurring since the 1970s [5,8,9].…”

Section: Introductionmentioning

confidence: 99%

Spousal Concordance in Dietary Behaviors and Metabolic Components, and Their Association: A Cross-Sectional Study

et al. 2020

View full text Add to dashboard Cite

This study aims to investigate spousal concordance in dietary behaviors, spousal concordance in metabolic components (MCs), and their association. A cross-sectional survey was conducted in Taiwan from November 2014 to May 2015. Matched-pair analysis, McNemar’s test, logistic regression analysis, and stratified analysis were performed. A total of 901 pairs of spouses (1802 participants) were analyzed. Husbands were less likely to report intakes of high-fiber food (ORMP (matched pairs odds ratio) = 0.30, p < 0.0001), fish (ORMP = 0.74, p = 0.0128), biscuits or cakes (ORMP = 0.60, p < 0.0001), and fast food (ORMP = 0.65, p = 0.01) compared with their wives. Husbands had significantly higher odds of being overweight (ORMP = 2.34, p < 0.0001); and of having hypertension (ORMP = 2.14, p < 0.0001), hypercholesterolemia (ORMP = 1.75, p = 0.0007), hyperlipidemia (ORMP = 2.96, p < 0.0001), and one or more metabolic components (composite MCs) (ORMP = 2.50, p < 0.0001) compared with their wives. After adjusting for age and education, the spousal concordance in high-fiber food intake was inversely associated with the spousal concordance in composite MCs (aOR = 0.62, 95% CI = 0.44−0.88, p = 0.0074), whereas the spousal concordance in processed food intake was positively associated with the concordance in composite MCs (aOR (adjusted odds ratio) = 1.56, 95% CI (Confidence Interval) = 1.03−2.36, p = 0.034). An intervention study for couples with intakes of different fiber foods and/or processed foods is critical for future study, in order to test what kinds of fiber foods/processed foods are associated with the development of the spousal concordance of metabolic components.

show abstract

Section: Introductionmentioning

confidence: 99%

Spousal Concordance in Dietary Behaviors and Metabolic Components, and Their Association: A Cross-Sectional Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is important to emphasize that when banana flour was included in the HFD, the amount of protein was substantially reduced. Diets high in fats and carbohydrates and low in proteins are commonly consumed worldwide and are highly related to the development of metabolic diseases (Dharavath et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies in humans and rodents have indicated that a low‐protein diet can lead to the development of fatty liver and steatosis (Dharavath et al, 2019; Ghosh et al, 2014; Mayneris‐Perxachs et al, 2016; van Zutphen et al, 2016). The mechanism involved in this process may be related to the downregulation of peroxisome proliferator‐activated receptor alpha (PPARα), transcription factors are responsible for fatty acid degradation, synthesis, transport, storage, and lipoprotein metabolism in hepatocytes (Ampong et al, 2020; Rech et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Unripe banana flour ( Musa cavendishii ) promotes increased hypothalamic antioxidant activity, reduced caloric intake, and abdominal fat accumulation in rats on a high‐fat diet

Santiago

Oliveira

Rocha-Gomes

et al. 2022

Journal of Food Biochemistry

View full text Add to dashboard Cite

The present study aimed to evaluate the nutritional and redox status of supplementation with unripe banana flour (Musa cavendishii) in high‐fat‐fed Wistar rats. Male Wistar rats were divided into the following groups for 98 days: control—lab chow; unripe banana flour (UBF)—lab chow with added unripe banana flour; high‐fat (HFD)—lab chow with added lard; unripe banana flour + high‐fat (UBF + HFD)—lab chow with added unripe banana flour and lard. The HFD group showed higher caloric intake, weight gain, abdominal fat accumulation, steatosis, and oxidative stress in the hypothalamus than the other groups. Conversely, the HFD + UBF group showed reduced caloric intake, weight gain, and abdominal adipose tissue accumulation compared to the HFD group. Notably, an improvement in the redox state of the hypothalamus was observed in the HFD + UBF group. However, this group showed a worsening redox state and fat accumulation in the liver. Practical applications The prevalence of obesity has increased worldwide over the past 50 years, reaching pandemic levels. It is also possible that, although it is a multifactorial disease, the main cause of obesity development is still related to a high intake of high‐fat diets. Therefore, it is imperative to establish alternatives for the control and treatment of obesity. Here, we showed that unripe banana flour can improve hypothalamic antioxidant activity, reduce caloric intake, and prevent abdominal fat accumulation. These outcomes indicate the anti‐obesity potential of unripe banana flour and highlight the need for future studies. However, the damage observed in the liver indicated that, at the concentrations used in the present study, its use should be carefully evaluated.

show abstract

“…Sections of 5-μm thickness were cut and stained using hematoxylin and eosin. [ 12 ] Photomicrographs were captured using a light microscope attached with a digital camera (Nikon-TS100F Charge Coupled Device, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

Co-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate

et al. 2020

Self Cite

View full text Add to dashboard Cite

OBJECTIVE: Methylphenidate (MPH) is a first-line treatment option for attention-deficit hyperactive disorder and narcolepsy. MPH is one of the most abused psychostimulants by the adults and young population to stay awake, perform better, or improve concentration. The scanty reports say that the medical users or abusers mostly consider the administration of benzodiazepines to overcome the adverse effects, i.e., mood- and anxiety-related problems associated with MPH chronic abuse. This work aims to study the effect of alprazolam (ALZ) on MPH-associated adverse effects on liver and kidney. MATERIALS AND METHODS: Female Wistar rats ( n = 58) were administered with MPH (10, 20, and 40 mg/kg) and ALZ (5, 10, and 20 mg/kg) alone and in combination for 28 days. Bodyweight, feed intake, and water intake were monitored weekly. Parameters related to liver and renal function, oxidative stress, and histopathology were performed to evaluate the toxic impacts on the liver and kidneys. RESULTS: ALZ, along with MPH, increased the serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, creatinine, and urea levels. The co-abuse also led to elevated oxidative stress and structural abnormalities in the liver and kidney tissues. CONCLUSION: The co-abuse of ALZ has amplified the hepato-renal toxic effects of MPH. Therefore, it is a significant concern for public safety, and their co-abuse must be restricted and discouraged.

show abstract

High fat-low protein diet induces metabolic alterations and cognitive dysfunction in female rats

Cited by 17 publications

References 58 publications

Spousal Concordance in Dietary Behaviors and Metabolic Components, and Their Association: A Cross-Sectional Study

Spousal Concordance in Dietary Behaviors and Metabolic Components, and Their Association: A Cross-Sectional Study

Unripe banana flour ( Musa cavendishii ) promotes increased hypothalamic antioxidant activity, reduced caloric intake, and abdominal fat accumulation in rats on a high‐fat diet

Co-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate

Contact Info

Product

Resources

About