High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction

Frazier, Katya; Kambal, Amal; Zale, Elizabeth; Pierre, Joseph F.; Hubert, Nathaniel; Miyoshi, Sawako; Miyoshi, Jun; Ringus, Daina L.; Harris, Dylan; Yang, Karen; Carroll, Katherine T.; Hermanson, Jake B.; Chlystek, John S.; Overmyer, Katherine A.; Cham, Candace M.; Musch, Mark W.; Coon, Joshua J.; Chang, Eugene B.; Leone, Vanessa

doi:10.1016/j.chom.2022.03.030

Cited by 51 publications

(49 citation statements)

References 45 publications

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“…Fat-enriched diet results in a continuous expression of Reg3γ to drive microbial oscillators. 144 Apart from light, clock genes can also respond to cues from diet. In mouse and fly models, CR, especially at night, has been found to enhance the amplitude of clock gene mRNA expression to promote longevity.…”

Section: Nutrient-associated Molecular Mechanismsmentioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

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Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan and delaying ageing in various species such as yeast, drosophila, rodent, primate and human. It emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse diseases. However, the nutritive advantages frequently diversify among individuals as well as organs and tissues, which brings challenges in this field. In this review, we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or clinical. We discuss the nutrient-mediated mechanisms including metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks. Comparably, we describe diet-responsive effectors by which dietary interventions influence the endocrinic, immunological, microbial and neural states responsible for improving health and preventing multiple diseases in humans. Furthermore, we expatiate diverse patterns of dietotheroapies, including different fasting, calorie-restricted diet, ketogenic diet, high-fibre diet, plants-based diet, protein restriction diet or diet with specific reduction in amino acids or microelements, potentially affecting the health and morbid states. Altogether, we emphasize the profound nutritional therapy, and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.

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Section: Nutrient-associated Molecular Mechanismsmentioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

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“…Moreover, previous reports in mice have described how diet alterations and stress program non-genetically inherited phenotypes in subsequent generations of progeny 5,16,44 . The microbiome and the immune system have been independently linked to both changes in diet and stress [45][46][47] and thus it is plausible that modifications in diet or introduction of persistent stress and the resulting microbial and immune alterations are responsible for altering epigenetic information in the gametes and intergenerational information transfer. Teleologically, we believe our observations suggest microbial presence can provide environmental context to offspring to allow for optimal use of energy and metabolism.…”

Section: Discussionmentioning

confidence: 99%

The microbiota and immune system non-genetically affect offspring phenotypes transgenerationally

Harris

Trigg

Goshu

et al. 2023

Preprint

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The host-microbiota relationship has evolved to shape mammalian processes, including immunity, metabolism, and development. Host phenotypes change in direct response to microbial exposures by the individual. Here we show that the microbiota induces phenotypic change not only in the individual but also in their succeeding generations of progeny. We found that germ-free mice exhibit a robust sebum secretion defect and transcriptional changes in various organs, persisting across multiple generations despite microbial colonization and breeding with conventional mice. Host-microbe interactions could be involved in this process, since T cell-deficient mice, which display defective sebum secretion, also transgenerationally transmit their phenotype to progeny. These phenotypes are inherited by progeny conceived duringin vitrofertilization using germ-free sperm and eggs, demonstrating that epigenetic information in the gametes is required for phenotypic transmission. Accordingly, small non-coding RNAs that can regulate embryonic gene expression were strikingly and similarly altered in gametes of germ-free and T cell-deficient mice. Thus, we have uncovered a novel mechanism whereby the microbiota and immune system induce phenotypic changes in successive generations of offspring. This epigenetic form of inheritance could be advantageous for host adaptation to environmental perturbation, where phenotypic diversity can be introduced more rapidly than by genetic mutation.

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“…However, to achieve greater fat intake, parents may be opting to give foods that their child prefers most, such as snacks that are rich in saturated fats (33). As high saturated fat intake can have adverse long-term effects on cardiovascular and metabolic health (34), education for parents regarding selection of healthy high-fat foods is recommended.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Dietary Intake of Children With Esophageal Atresia: A Prospective, Controlled, Observational Study

Traini

Chan

Menzies³

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objectives: Children with esophageal atresia (EA) often have feeding difficulties and dysphagia, which may compromise their nutritional status. This study aimed to compare dietary intake between children with EA and matched healthy controls (HC) and to investigate the relationship between dietary factors, growth, dysphagia, and feeding difficulties in the EA cohort. Methods: This cross-sectional cohort study recruited children with EA and HC aged 2–17 years from a tertiary pediatric hospital in Australia. Growth parameters were measured. Dietary intake was assessed using the validated Australian Child and Adolescent Eating Survey. Dysphagia and feeding difficulties were assessed using objective questionnaires. Results: Twenty-one children with EA were matched for age and sex with 21 HC. Compared to HC, children with EA had lower mean z scores for height-for-age, but mean weight-for-age and body mass index-for-age z scores were similar. Energy intake was similar between the groups. The diet of children with EA consisted of a higher proportion of fats and lower proportion of carbohydrates compared to matched HC. Dysphagia severity in children with EA positively correlated with proportion of energy from fats and saturated fats. Conclusions: Children with EA have similar energy intake and growth parameters to HC, but their diet consists of a higher proportion of fats and lower proportion of carbohydrates compared to HC. Targeted dietary interventions and parental education are necessary.

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High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction

Cited by 51 publications

References 45 publications

Dietary regulation in health and disease

Dietary regulation in health and disease

The microbiota and immune system non-genetically affect offspring phenotypes transgenerationally

Evaluating the Dietary Intake of Children With Esophageal Atresia: A Prospective, Controlled, Observational Study

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