High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma

Ma, Ruimin; Kang, Xiaojian; Zhang, Guojun; Fang, Fang; Du, Yamei; Lv, Hong

doi:10.3892/ol.2016.4171

Cited by 46 publications

(41 citation statements)

References 27 publications

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“…This ubiquitin-conjugating enzyme is an important regulator in cell cycle progression, and overexpression has been associated with progression of malignant gliomas. 38 There is a substantial amount of LD in Hispanics between SNPs within 50KB of UBE2C , including SNPs in WFDC3, DNTTIP1 , TNNC2 , SNX21 , ACOT8 , and ZSWIM3 . WFDC3 functions as a protease inhibitor, and notably, both protein degradation though ubiquitination and protease inhibition are represented among neurodegenerative diseases.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities

et al. 2017

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Objective:To investigate genetic variants influencing white matter hyperintensities (WMHs) in the understudied Hispanic population.Methods:Using 6.8 million single nucleotide polymorphisms (SNPs), we conducted a genome-wide association study (GWAS) to identify SNPs associated with WMH volume (WMHV) in 922 Hispanics who underwent brain MRI as a cross-section of 2 community-based cohorts in the Northern Manhattan Study and the Washington Heights–Inwood Columbia Aging Project. Multiple linear modeling with PLINK was performed to examine the additive genetic effects on ln(WMHV) after controlling for age, sex, total intracranial volume, and principal components of ancestry. Gene-based tests of association were performed using VEGAS. Replication was performed in independent samples of Europeans, African Americans, and Asians.Results:From the SNP analysis, a total of 17 independent SNPs in 7 genes had suggestive evidence of association with WMHV in Hispanics (p < 1 × 10−5) and 5 genes from the gene-based analysis with p < 1 × 10−3. One SNP (rs9957475 in GATA6) and 1 gene (UBE2C) demonstrated evidence of association (p < 0.05) in the African American sample. Four SNPs with p < 1 × 10−5 were shown to affect binding of SPI1 using RegulomeDB.Conclusions:This GWAS of 2 community-based Hispanic cohorts revealed several novel WMH-associated genetic variants. Further replication is needed in independent Hispanic samples to validate these suggestive associations, and fine mapping is needed to pinpoint causal variants.

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Section: Discussionmentioning

confidence: 99%

Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities

et al. 2017

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“…Gliomas are malignant tumors with the highest morbidity and mortality rate, and their highly aggressive and invasive nature contributes to poor prognoses in patients. In recent years, the prevalence of gliomas has increased [ 1 – 2 ]. Despite ongoing research, the mechanisms of gliomagenesis and glioma morbidity remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/β-catenin signaling pathway

et al. 2016

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CircRNA is a novel type of RNA molecule formed by a covalently closed loop which have no 5′-3′ polarity and possess no polyA tail and relatively stable due to the cyclic structure. Therefore, they may serve as potential targets and diagnosis biomarkers for tumor therapy. cZNF292 is an important circular oncogenic RNA and plays a critical role in the progression of tube formation. This study is aimed at exploring the role of cZNF292 in human glioma tube formation and its potential mechanism of action. We found that cZNF292 silencing suppresses tube formation by inhibiting glioma cell proliferation and cell cycle progression. Cell cycle progression in human glioma U87MG and U251 cells was halted at S/G2/M phase via the Wnt/β-catenin signaling pathway and related genes such as PRR11, Cyclin A, p-CDK2, VEGFR-1/2, p-VEGFR-1/2 and EGFR. The results suggest that cZNF292 silencing plays an important role in the tube formation process and has potential for application as a therapeutic target and biomarker in glioma.

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“…As we know that, ubiquitin-conjugating enzyme E2C (UBE2C) is a key regulator of cell cycle progression. High expression of UBE2C is associated with aggressive progression and poor outcome of malignant glioma, 21 and UBE2C has been identified as a prognostic protein marker in bladder cancer. 22 Moreover, UBE2C, DLGAP5, and TPX2 are associated with the progression and prognosis of pancreatic carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Identification of genes and analysis of prognostic values in nonsmoking females with non-small cell lung carcinoma by bioinformatics analyses

Yang¹,

Chen²,

Xiao³

et al. 2018

CMAR

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BackgroundThis study was performed to identify disease-related genes and analyze prognostic values in nonsmoking females with non-small cell lung carcinoma (NSCLC).Materials and methodsGene expression profile GSE19804 was downloaded from the Gene Expression Omnibus (GEO) database and analyzed by using GEO2R. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were used for the functional and pathway enrichment analysis. Then, the Search Tool for the Retrieval of Interacting Genes, Cytoscape, and Molecular Complex Detection were used to construct the protein–protein interaction (PPI) network and identify hub genes. Finally, the Kaplan–Meier plotter online tool was used for the overall survival analysis of hub genes.ResultsA cohort of 699 differentially expressed genes was screened, and they were mainly enriched in the terms of ECM–receptor interaction, focal adhesion, and cell adhesion molecules. A PPI network was constructed, and 15 hub genes were identified base on the subset of PPI network. Then, two significant modules were detected and several genes were found to be associated with the cell cycle pathway. Finally, nine hub genes’ (UBE2C, DLGAP5, TPX2, CCNB2, BIRC5, KIF20A, TOP2A, GNG11, and ANXA1) expressions were found to be associated with the prognosis of the patients.ConclusionOverall, we propose that the cell cycle pathway may play an important role in nonsmoking females with NSCLC and the nine hub genes may be further explored as potential targets for NSCLC diagnosis and treatment.

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High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma

Cited by 46 publications

References 27 publications

Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities

Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities

Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/β-catenin signaling pathway

Identification of genes and analysis of prognostic values in nonsmoking females with non-small cell lung carcinoma by bioinformatics analyses

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