High expression of microRNA-454 is associated with poor prognosis in triple-negative breast cancer

Cao, Zhi; Li, Jun Jing; Yao, Ling; Huang, Yan; Liu, Yi-Rong; Hu, Xin; Song, Chuan; Shao, Zhi Ming

doi:10.18632/oncotarget.11764

Cited by 48 publications

(46 citation statements)

References 31 publications

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“…[17] No significant heterogeneity was observed across studies (OS, I 2 = 0.00%, P = .925; DFS, I 2 = 0.00%, P = .949). The fixed-effects model revealed that miR-454 expression was inversely associated with OS (combined adjusted HR: 6.74; 95% CI: 2.72–16.73) and DFS (combined adjusted HR: 3.72; 95% CI: 1.94–7.12) in TNBC patients (Fig.…”

Section: Resultsmentioning

confidence: 99%

MicroRNAs in the prognosis of triple-negative breast cancer

Mao

Shi

et al. 2017

Medicine

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Background:Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors characterized by their aggressive nature and poor associated survival. MicroRNAs (miRs) have been found to play an important role in the occurrence and development of human cancers, but their role in the prognosis of TNBC patients remains unclear. We performed a meta-analysis to explore the prognostic value of miRs in TNBC.Methods:We systematically searched the PubMed, Embase, and Web of Science databases to identify eligible studies. A meta-analysis was performed to estimate the pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) for the associations between levels of miR expression (predictive factors) and overall survival (OS) and disease-free survival (DFS) (outcomes) in patients with TNBC.Results:After performing the literature search and review, 21 relevant studies including 2510 subjects were identified. Six miRs (miR-155, miR-21, miR-27a/b, miR-374a/b, miR-210, and miR-454) were assessed in the meta-analysis. Decreased expression of miR-155 was associated with reduced OS (adjusted HR = 0.58, 95% CI: 0.34–0.99; crude HR = 0.67, 95% CI: 0.58–0.79). High miR-21 expression was also predictive of reduced OS (crude HR = 2.50, 95% CI: 1.56–4.01). We found that elevated levels of miR-27a/b, miR-210, and miR-454 expression were associated with shorter OS, while the levels of miR-454 and miR-374a/b expression were associated with DFS.Conclusions:Specific miRs could serve as potential prognostic biomarkers in TNBC. Due to the limited research available, the clinical application of these findings has yet to be verified.

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Section: Resultsmentioning

confidence: 99%

MicroRNAs in the prognosis of triple-negative breast cancer

Mao

Shi

et al. 2017

Medicine

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“…Choi et al (32) indicated that miR-141/200c was involved in TNBC migration and invasion via activating the focal adhesion kinase and phosphoinositide 3-kinase/AKT signaling pathways. miRNA-454 was revealed to be associated with poor prognosis in TNBC (17) and miRNA-200b could suppress TNBC metastasis by regulating protein kinase C α (19). Furthermore, miR-211-5p served a tumor suppressor role in TNBC progression by targeting SETBP1 (33) and miRNA-21 could promote TNBC cell proliferation and invasion by regulating phosphatase and tensin homolog (34).…”

Section: Discussionmentioning

confidence: 99%

“…A growing number of studies have indicated that abnormal expression of miRs is associated with human breast cancer (11)(12)(13)(14)(15)(16). Furthermore, mounting evidence indicates that miRs serve key functions in the development of TNBC (17)(18)(19). However, the exact molecular mechanism of miRs in TNBC is not yet understood.…”

Section: Introductionmentioning

confidence: 99%

Effect of miR-146a-5p on proliferation and metastasis of triple-negative breast cancer via regulation of SOX5

Yao

2018

Exp Ther Med

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Abstract. MicroRNA (miR)-146a-5p functions as a tumor suppressor in various types of cancer. However, the role of miR-146a-5p in the development of triple-negative breast cancer (TNBC) is unclear. The present study aimed to investigate the role of miR-146a-5p in TNBC. The expression level of miR-146a-5p in TNBC tissues and cell lines was initially detected using reverse transcription-quantitative polymerase chain reaction. To predict the target gene of miR-146a-5p, TargetScan software was used and a dual luciferase assay was performed to verify the prediction. Furthermore, in order to explore the role of miR-146a-5p in TNBC, miR-146a-5p was overexpressed in TNBC cells using miR-146a-5p mimics. An MTT assay was performed to detect cell proliferation, and a Transwell assay was conducted to determine cell migration and invasion. Furthermore, western blotting was performed to measure associated protein expression. It was revealed that miR-146a-5p was downregulated in TNBC tissues and cell lines. SOX5 was indicated to be a target gene of miR-146a-5p and was upregulated in TNBC cells. Additionally, miR-146a-5p could inhibit TNBC cell proliferation, migration and invasion, repress the expression of mesenchymal markers (N-cadherin, vimentin and fibronectin) and increase epithelial marker (E-cadherin) expression. Furthermore, SOX5 overexpression eliminated the effects of miR-146a-5p mimics on TNBC cells. In conclusion, the data of the present study indicated that miR-146a-5p inhibits the proliferation and metastasis of TNBC cells by regulating SOX5.

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“…In the last decade, numerous miRNAs have been investigated as prognostic and diagnostic biomarkers and therapeutic targets. Cao et al revealed that miR-454 overexpression was correlated with unfavorable prognosis for patients with triple-negative breast cancer [24]. In the study of Wei et al, they reported that miR-1 was signi cantly downregulated in recurrent PCa tissues and it can function as an independent predictive factor for PCa [25].…”

Section: Discussionmentioning

confidence: 99%

MiR-378 Has the Capacity to Serve as a Diagnostic Biomarker for Prostate Cancer Patient

Cao

Zheng

2020

Preprint

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Background: This study aimed to examine the expression of serum miR-378 in prostate cancer (PCa) patients and healthy individuals and to identify the value of miR-378 in PCa diagnosis.Methods: The expression of serum miR-378 between groups was compared by t-test. The association between miR-378 expression and clinical characteristics of PCa patients was assessed using Chi-square test. The diagnostic value of serum miR-378 in PCa was estimated by the receiver operating characteristic (ROC) analysis.Results: The expression level of serum miR-378 in PCa patients was significantly lower than that in healthy individuals (P<0.0001). MiR-378 expression was affected by positive AR (P=0.004), large Gleason score (P=0.013) and advanced TNM stage (P=0.020), however, it had no relationship with age, serum PSA, NED rate and urine retention (all, P>0.05). The ROC curve showed that the optimal cutoff value was 1.845, giving the sensitivity and specificity of 75.21% and 89.77%, respectively. Besides, the area under the ROC curve (AUC) was 0.894, indicating serum miR-378 was of great diagnostic value in screening PCa patients from healthy controls (P<0.0001, 95%CI =0.852-0.936).Conclusions: Taken together, the increased expression of serum miR-378 might act as a potential biomarker for PCa diagnosis.

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High expression of microRNA-454 is associated with poor prognosis in triple-negative breast cancer

Cited by 48 publications

References 31 publications

MicroRNAs in the prognosis of triple-negative breast cancer

MicroRNAs in the prognosis of triple-negative breast cancer

Effect of miR-146a-5p on proliferation and metastasis of triple-negative breast cancer via regulation of SOX5

MiR-378 Has the Capacity to Serve as a Diagnostic Biomarker for Prostate Cancer Patient

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