2021
DOI: 10.21203/rs.3.rs-368412/v1 View full text |Buy / Rent full text
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Abstract: Identifying new prognostic biomarkers and selecting treatment regimens based on them can improve outcomes of adult patients with B-cell acute lymphoblastic leukemia (B-ALL). Extracellular matrix protein 1(ECM1) is a glycoprotein involved in many biologic processes. Here we aimed to determine the expression and the prognostic value of ECM1 in B-ALL. One hundred and six newly-diagnosed B-ALL patients (seventy-one adult patients and thirty-five children patients) were enrolled from March 2013 to December 2018. Th… Show more

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“…Thirdly, some factors associated to prognosis are not included in this nomogram model. For example, CNSL is one of the main reasons of recurrence, which will affect the prognosis of ALL patients (25). However, based on the situation that the incidence of CNSL is relatively low at initial diagnosis of adult ALL, we could not carry out statistical analysis in this study.…”
Section: Discussionmentioning
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“…Thirdly, some factors associated to prognosis are not included in this nomogram model. For example, CNSL is one of the main reasons of recurrence, which will affect the prognosis of ALL patients (25). However, based on the situation that the incidence of CNSL is relatively low at initial diagnosis of adult ALL, we could not carry out statistical analysis in this study.…”
Section: Discussionmentioning
“…The cases were follow-up until death, loss of follow-up, or at November 2021. The diagnosis of ALL, complete remission (CR), relapse, and risk stratification was defined according to Chinese guidelines for diagnosis and treatment of adult acute lymphoblastic leukemia (2021) (25). Clinical information was extracted from patient medical records and mainly included gender, age, WBC, hemoglobin (HGB), platelet (PLT), peripheral blasts (PB), bone marrow (BM) blasts at diagnosis, immunophenotype, fusion gene, gene mutations and chromosomal karyotype, risk stratification, treatment regimens, complications, transplant, and survival status.…”
Section: Introductionmentioning