High electrical resistance of the bombykol cell in an olfactory sensillum of Bombyx mori: Voltage- and current-clamp analysis

Redkozubov, Alexei

doi:10.1016/0022-1910(95)00002-c

Cited by 11 publications

(7 citation statements)

References 14 publications

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“…A similar partition between apical and basolateral resistances was postulated for the auxiliary cells by De Kramer (1985) to simulate capacitive properties of the sensillum (which are not considered here). A high specific resistance of the apical membrane of the receptor-cell dendrite also results from the analysis of Redkozubov (1995). After adjusting the membrane resistances, the resting TEP at 18~ was matched by choosing a tormogen-trichogen voltage source (ET) of 39.7 mV at 18~ (Fig.…”

Section: Appendixmentioning

confidence: 99%

Effects of temperature on silkmoth olfactory responses to pheromone can be simulated by modulation of resting cell membrane resistances

Kodadova¹,

Kaissling²

1996

J Comp Physiol A

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Electrophysiological parameters were measured at different temperatures in resting and pheromone-stimulated olfactory sensilla trichodea of male Antheraea polyphemus (Saturniidae). A method for selective cooling of either the olfactory hair or the antennal branch was developed. The resting preparation resistance increased with lower temperatures, the transepithelial potential decreased. These effects were also observed when the antennal branch was cooled, but were absent during cooling the hair, suggesting a major influence of auxiliary cells on the transepithelial potential and resistance. Together with the preparation resistance, the responses to pheromone stimuli increased with lower temperatures.Computer simulation of the current flow in the sensillum showed that the temperature dependence of responses to pheromone can be explained by modulation of resting resistances of cell membranes alone, without effects of temperature on stimulus transduction. The weak temperature dependence of transepithelial potential might be due to temperature dependence of the electrogenic pump producing the transepithelial potential. Selective cooling of the olfactory hair had no effect on the shape of nerve impulses, cooling of the antennal branch caused changes similar to that obtained by cooling the entire sensillum. This supports the idea that the nerve impulses are generated in the soma of the receptor cell.

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Section: Appendixmentioning

confidence: 99%

Effects of temperature on silkmoth olfactory responses to pheromone can be simulated by modulation of resting cell membrane resistances

Kodadova¹,

Kaissling²

1996

J Comp Physiol A

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“…Despite the lack of direct synaptic connections, transient activation of one ORN rapidly suppresses the ongoing activity of its neighbor 11 . Electric circuit modeling suggested a potential mechanism for this nonsynaptic signaling 11,12 : in the restrictive space of a sensillum lumen, the high resistance of the lymph 13 favors the generation of field effects between compartmentalized ORNs 2,3 . However, whether ephaptic interaction underlies the inhibition between ORNs has not been directly demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons

et al. 2019

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In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this underexplored form of lateral inhibition remain unclear. Here we use recordings from pairs of sensilla impaled by the same tungsten electrode to demonstrate that direct electrical (“ephaptic”) interactions mediate lateral inhibition between ORNs. Intriguingly, within individual sensilla, we find that ephaptic lateral inhibition is asymmetric such that one ORN exerts greater influence onto its neighbor. Serial block-face scanning electron microscopy of genetically identified ORNs and circuit modeling indicate that asymmetric lateral inhibition reflects a surprisingly simple mechanism: the physically larger ORN in a pair corresponds to the dominant neuron in ephaptic interactions. Thus, morphometric differences between compartmentalized ORNs account for highly specialized inhibitory interactions that govern information processing at the earliest stages of olfactory coding.

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“…Despite the lack of synaptic connections between neighboring ORNs, transient activation of one ORN rapidly suppresses the ongoing activity of its neighbor 10 . Electric circuit modeling suggested a potential mechanism for this non-synaptic signaling 10,11 : in the restrictive space of a sensillum lumen, the high resistance of the lymph 12 favors the generation of field effects between compartmentalized ORNs 2,3 . However, whether ephaptic interaction underlies the inhibition between ORNs has not been directly demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons

Zhang

Tsang

Bushong

et al. 2018

Preprint

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In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this unusual form of lateral inhibition remain unclear. Here we use recordings from pairs of sensilla impaled by the same tungsten electrode to prove that direct electrical ("ephaptic") interactions mediate lateral inhibition between ORNs. Intriguingly, within individual sensilla, we find that ephaptic lateral inhibition is asymmetric such that one ORN exerts greater influence onto its neighbor. Serial block-face scanning electron microscopy of genetically identified ORNs and circuit modeling indicate that asymmetric lateral inhibition reflects a surprisingly simple mechanism: the physically larger ORN in a pair corresponds to the dominant neuron in ephaptic interactions. Thus, morphometric differences between compartmentalized ORNs account for highly specialized inhibitory interactions that govern information processing at the earliest stages of olfactory coding.

show abstract

High electrical resistance of the bombykol cell in an olfactory sensillum of Bombyx mori: Voltage- and current-clamp analysis

Cited by 11 publications

References 14 publications

Effects of temperature on silkmoth olfactory responses to pheromone can be simulated by modulation of resting cell membrane resistances

Effects of temperature on silkmoth olfactory responses to pheromone can be simulated by modulation of resting cell membrane resistances

Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons

Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons

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