J. Neurosci. Res. volume 86, issue 9, P2083-2090 2008 DOI: 10.1002/jnr.21650 View full text
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Haiqun Jia, Xin Li, Hongxiang Gao, Zhihui Feng, Xuesen Li, Lei Zhao, Xu Jia, Hongyu Zhang, Jiankang Liu

Abstract: Nicotinamide, the principal form of niacin (vitamin B3), has been proposed to be neuroprotective in Parkinson's disease. However, the effects and mechanisms of nicotinamide on motor function in animals and on mitochondrial function in cellular systems have not been well studied. We hypothesized that niacin-derived NAD(P)H as antioxidants and enzyme cofactors could inhibit oxidative damage and improve mitochondrial function and thus protect neurodegeneration and improve motor function. In the present study, the…

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