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Cited by 219 publications
(203 citation statements)
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“…We have therefore hypothesized that high-dose UVAl radiation, by virtue of its capacity to increase collagenase I expression, may have beneficial effects for patients with localized scleroderma. We have tested this hypothesis in a recent pilot study, in which ten patients with histologically proven localized scleroderma were exposed 30 times to 130 J/cm2 of UVAl radiation (6). In all patients, high-dose UVAl therapy softened sclerotic plaques, and complete clearance was observed in four out of ten patients.…”
Section: High Dose Uval Therapy For Localized Sclerodermamentioning
confidence: 99%
“…We have therefore hypothesized that high-dose UVAl radiation, by virtue of its capacity to increase collagenase I expression, may have beneficial effects for patients with localized scleroderma. We have tested this hypothesis in a recent pilot study, in which ten patients with histologically proven localized scleroderma were exposed 30 times to 130 J/cm2 of UVAl radiation (6). In all patients, high-dose UVAl therapy softened sclerotic plaques, and complete clearance was observed in four out of ten patients.…”
Section: High Dose Uval Therapy For Localized Sclerodermamentioning
confidence: 99%
“…Egyptian investigators, El Mofty et al in 2000 examined application of low, wide spectrum UVA doses (applicable in a PUVA chamber) in 12 patients with 20 exposures and obtained a good effect [39]. In 2004, the same authors compared various doses of wide spectrum UVA (5-10-20 J/cm 2 ) in consecutive 16-21-26 patients who received 20 exposures and detected better response in treatment of fresh foci [41] Stege et al in 1997 conducted comparative studies on 10 patients with morphea, treated with a high UVA1 dose of 130 J/cm 2 and receiving 30 exposures to the total dose of 3900 J/cm 2 vs. 7 patients treated with a low dose of 20 J/cm 2 and receiving 30 exposures (total dose of 600 J/cm 2 ), demonstrating better results at higher dosages, compared to the lower dose [42]. At the end of 2006 the most valuable comparative study was published.…”
Section: Phototherapy In Morpheamentioning
confidence: 99%
“…Stege et al compared high-dose with lowdose UVA1 phototherapy, and observed a very good response with high-dose UVA1 (130 J/cm 2 ) but no response with low-dose UVA1 (20 J/cm 2 ) [22]. Shortly thereafter, Kerscher et al reported excellent results using low-dose UVA1 (20 J/cm 2 ) in 20 patients for a total of 30 sessions [23].…”
Section: Morphea (Localized Scleroderma)mentioning
confidence: 99%