Abstract:Background:
Solid organ transplantation is an available therapeutic option for cystic fibrosis (CF) patients without lung transplantation. However, the use of immunosuppressive agents may cause severe adverse events. In particular, patients treated with mTOR-inhibitors (mTOR-I) may aggravate pulmonary complications. It has been recently described that these drugs may induce epithelial to mesenchymal transition (EMT) of airway cells.
Objective:
The purpose of this study was to evaluate the effects of mTOR-I … Show more
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