High-dose epinephrine results in greater early mortality after resuscitation from prolonged cardiac arrest in pigs: A prospective, randomized study

Effect of adrenaline dose on neurological outcome in out-of-hospital cardiac arrest: a nationwide propensity score analysis

“…The favourable neurologic outcome was also statically lower. These results are consistent with experimental and observational studies showing that higher doses of adrenaline result in a poorer survival rate at hospital discharge and neurologic outcome [22,23].…”

Effect of adrenaline dose on neurological outcome in out-of-hospital cardiac arrest: a nationwide propensity score analysis

“…The favourable neurologic outcome was also statically lower. These results are consistent with experimental and observational studies showing that higher doses of adrenaline result in a poorer survival rate at hospital discharge and neurologic outcome [22,23].…”

Ivabradine-Induced Heart Rate Reduction Increases the Severity of Postresuscitation Myocardial Dysfunction in a Rat Model of Cardiopulmonary Resuscitation

“…Microcirculatory derangement as expressed by poorer PVD and MFI could also be attributed to a similar mechanism. Excessive epinephrine surely aggravates myocardial ischemia and dysfunction with β1 and α-adrenergic actions and leads to increased severity of myocardial injury as indicated by elevated serum cTnI concentrations and a strikingly shortened survival duration as shown in the present study, a process that has been supported by earlier experiments in animals (3,21).…”

Experimental Cardiac Arrest Treatment with Adrenaline, Vasopressin, or Placebo

“…It was observed also that adrenaline has lost its pressure effect after the third dose; vasopressin maintained a significant pressure effect during 30 minutes of CPR; and placebo, i.e ., CPR itself maintained a pressure effect during few minutes. In other studies, pressure effects similar to these have been observed 14-18 . It is important to highlight that blood concentration of endogenous epinephrine and vasopressin increases during CPR 19,20 .…”

Effect of adrenaline dose on neurological outcome in out-of-hospital cardiac arrest: a nationwide propensity score analysis

“…The favourable neurologic outcome was also statically lower. These results are consistent with experimental and observational studies showing that higher doses of adrenaline result in a poorer survival rate at hospital discharge and neurologic outcome [22,23].…”

Ivabradine-Induced Heart Rate Reduction Increases the Severity of Postresuscitation Myocardial Dysfunction in a Rat Model of Cardiopulmonary Resuscitation

“…Microcirculatory derangement as expressed by poorer PVD and MFI could also be attributed to a similar mechanism. Excessive epinephrine surely aggravates myocardial ischemia and dysfunction with β1 and α-adrenergic actions and leads to increased severity of myocardial injury as indicated by elevated serum cTnI concentrations and a strikingly shortened survival duration as shown in the present study, a process that has been supported by earlier experiments in animals (3,21).…”

Experimental Cardiac Arrest Treatment with Adrenaline, Vasopressin, or Placebo

“…It was observed also that adrenaline has lost its pressure effect after the third dose; vasopressin maintained a significant pressure effect during 30 minutes of CPR; and placebo, i.e ., CPR itself maintained a pressure effect during few minutes. In other studies, pressure effects similar to these have been observed 14-18 . It is important to highlight that blood concentration of endogenous epinephrine and vasopressin increases during CPR 19,20 .…”

Effect of adrenaline dose on neurological outcome in out-of-hospital cardiac arrest: a nationwide propensity score analysis

“…The favourable neurologic outcome was also statically lower. These results are consistent with experimental and observational studies showing that higher doses of adrenaline result in a poorer survival rate at hospital discharge and neurologic outcome [22,23].…”

Ivabradine-Induced Heart Rate Reduction Increases the Severity of Postresuscitation Myocardial Dysfunction in a Rat Model of Cardiopulmonary Resuscitation

“…Microcirculatory derangement as expressed by poorer PVD and MFI could also be attributed to a similar mechanism. Excessive epinephrine surely aggravates myocardial ischemia and dysfunction with β1 and α-adrenergic actions and leads to increased severity of myocardial injury as indicated by elevated serum cTnI concentrations and a strikingly shortened survival duration as shown in the present study, a process that has been supported by earlier experiments in animals (3,21).…”

Experimental Cardiac Arrest Treatment with Adrenaline, Vasopressin, or Placebo

“…It was observed also that adrenaline has lost its pressure effect after the third dose; vasopressin maintained a significant pressure effect during 30 minutes of CPR; and placebo, i.e ., CPR itself maintained a pressure effect during few minutes. In other studies, pressure effects similar to these have been observed 14-18 . It is important to highlight that blood concentration of endogenous epinephrine and vasopressin increases during CPR 19,20 .…”