High-Dose Corticosteroid Regimen Retards Development of Multiple Sclerosis in Optic Neuritis Treatment Trial

Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis

“…Both these patients had MRI lesions suggestive of multiple sclerosis prior to enrolment in the study. It has been said that recurrence rate and the probability of developing clinically defined multiple sclerosis (CDMS) is higher in presence of MRI lesions 9,12. …”

Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis

“…Both these patients had MRI lesions suggestive of multiple sclerosis prior to enrolment in the study. It has been said that recurrence rate and the probability of developing clinically defined multiple sclerosis (CDMS) is higher in presence of MRI lesions 9,12. …”

Optic Neuritis: Clinical Analysis of 27 Cases

“…The ONTT found that administration of high-dose intravenous methylprednisolone followed by oral prednisolone (1 mg/dg/day) for 11 days led to slightly faster recovery of visual function than placebo, especially within the first 3 weeks following treatment. However, the final visual acuity in these patients after 6 months was not significantly different from that in the placebo group [3,21]. Treatment with oral prednisolone (1 mg/kg/day) alone for 14 days has no beneficial effect on visual recovery and increases the recurrence of ON [22,23].…”

Neuro-oftalmologia: Sistema sensorial - parte I revisão 1997-1999

“…Em outro trabalho sobre o risco de conversão de neurite óptica em EM, Trobe (79) comenta que a pulsoterapia com metilprednisolona, que pode não ser útil para a recuperação visual, é aconselhável quando a IRM mostra duas ou mais lesões com diâmetro igual ou maior que 3 mm, uma vez que o tratamento reduz a taxa de conversão para EM no período de dois anos. No entanto, a probabilidade cumulativa após cinco anos é a mesma nos grupos tratado e não tratado (76) .…”

Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis

“…Both these patients had MRI lesions suggestive of multiple sclerosis prior to enrolment in the study. It has been said that recurrence rate and the probability of developing clinically defined multiple sclerosis (CDMS) is higher in presence of MRI lesions 9,12. …”

Optic Neuritis: Clinical Analysis of 27 Cases

“…The ONTT found that administration of high-dose intravenous methylprednisolone followed by oral prednisolone (1 mg/dg/day) for 11 days led to slightly faster recovery of visual function than placebo, especially within the first 3 weeks following treatment. However, the final visual acuity in these patients after 6 months was not significantly different from that in the placebo group [3,21]. Treatment with oral prednisolone (1 mg/kg/day) alone for 14 days has no beneficial effect on visual recovery and increases the recurrence of ON [22,23].…”

Neuro-oftalmologia: Sistema sensorial - parte I revisão 1997-1999

“…Em outro trabalho sobre o risco de conversão de neurite óptica em EM, Trobe (79) comenta que a pulsoterapia com metilprednisolona, que pode não ser útil para a recuperação visual, é aconselhável quando a IRM mostra duas ou mais lesões com diâmetro igual ou maior que 3 mm, uma vez que o tratamento reduz a taxa de conversão para EM no período de dois anos. No entanto, a probabilidade cumulativa após cinco anos é a mesma nos grupos tratado e não tratado (76) .…”

Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis

“…Both these patients had MRI lesions suggestive of multiple sclerosis prior to enrolment in the study. It has been said that recurrence rate and the probability of developing clinically defined multiple sclerosis (CDMS) is higher in presence of MRI lesions 9,12. …”

Optic Neuritis: Clinical Analysis of 27 Cases

“…The ONTT found that administration of high-dose intravenous methylprednisolone followed by oral prednisolone (1 mg/dg/day) for 11 days led to slightly faster recovery of visual function than placebo, especially within the first 3 weeks following treatment. However, the final visual acuity in these patients after 6 months was not significantly different from that in the placebo group [3,21]. Treatment with oral prednisolone (1 mg/kg/day) alone for 14 days has no beneficial effect on visual recovery and increases the recurrence of ON [22,23].…”

Neuro-oftalmologia: Sistema sensorial - parte I revisão 1997-1999

“…Em outro trabalho sobre o risco de conversão de neurite óptica em EM, Trobe (79) comenta que a pulsoterapia com metilprednisolona, que pode não ser útil para a recuperação visual, é aconselhável quando a IRM mostra duas ou mais lesões com diâmetro igual ou maior que 3 mm, uma vez que o tratamento reduz a taxa de conversão para EM no período de dois anos. No entanto, a probabilidade cumulativa após cinco anos é a mesma nos grupos tratado e não tratado (76) .…”