High-Dose Botulinum Toxin Type A for Axillary Hyperhidrosis

Schnider, Peter; Moraru, E.; Kittler, Harald; Voller, Bernhard; Auff, Eduard

doi:10.1001/archderm.136.12.1567

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…Since 3 months is the preferred minimum time interval for repeat injections, axillary hyperhidrosis can be treated effectively with BTX-A injections. 4 The treatments can likely be spaced further apart, such as two times per year, thus minimizing the risk of neutralizing antibody formation.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have demonstrated that BTX-A injections into the axillae result in dramatic reductions in sweat production. [1][2][3][4][5] There are reports that this effect can last 4-7 months or longer. However, the methods for quantitating the sweat rate have varied and there are no standardized methods for sweat collection.…”

Section: Ib R Odderson MD Phd Has Indicated No Significant Interesmentioning

confidence: 99%

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Long-Term Quantitative Benefits of Botulinum Toxin Type A in the Treatment of Axillary Hyperhidrosis

Odderson¹

2002

Dermatologic Surgery

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background. Although axillary hyperhidrosis is readily treated with botulinum toxin, the time course of benefits is not well established. objective. To quantify the long-term effectiveness of botulinum toxin type A (BTX-A) for the treatment of axillary hyperhidrosis. methods. This was a double-blind, placebo-controlled study. Eighteen patients received intradermal injections of either 100 U BTX-A (50 U/ml/axilla) or placebo. Sweating per surface area was quantified monthly for 5 months.results. The BTX-A group had an average reduction in sweat production of 91.6% at 2 weeks (from 5.03 ml/min/m 2 to 0.42 ml/min/m 2 , P Ͻ .05). The average reduction over 5 months was 88.2%. At the end of the study, only 1 of 12 BTX-A-treated patients had returned to baseline sweat production. conclusion. These quantitative results demonstrate that BTX-A is a safe and effective treatment for axillary hyperhidrosis and that the benefits last for at least 5 months.

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Section: Discussionmentioning

confidence: 99%

Section: Ib R Odderson MD Phd Has Indicated No Significant Interesmentioning

confidence: 99%

Long-Term Quantitative Benefits of Botulinum Toxin Type A in the Treatment of Axillary Hyperhidrosis

Odderson¹

2002

Dermatologic Surgery

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show abstract

“…The sweat rates were significantly suppressed beyond 5 months. Since 3 months is the preferred minimum time interval for repeat injections, axillary hyperhidrosis can be treated effectively with BTX‐A injections 4 . The treatments can likely be spaced further apart, such as two times per year, thus minimizing the risk of neutralizing antibody formation.…”

Section: Discussionmentioning

confidence: 99%

“…Botulinum toxin type A (BTX‐A) has been shown to be both effective and safe for focal hyperhidrosis. Recent studies have demonstrated that BTX‐A injections into the axillae result in dramatic reductions in sweat production 1–5 . There are reports that this effect can last 4–7 months or longer.…”

mentioning

confidence: 99%

Long-Term Quantitative Benefits of Botulinum Toxin Type A in the Treatment of Axillary Hyperhidrosis

Odderson

2002

Dermatol Surg

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“…The effects of BTX‐A do not disappear completely at the end of 1 year. The optimal dose and the lowest dose for the treatment of axillary hyperhidrosis still needs to be defined to minimize dose‐related side‐effects, to lower the costs of treatment and to reduce the risk of antibody formation 4,10 …”

Section: To the Editormentioning

confidence: 99%