High Disease Activity Is Associated with Self-reported Depression and Predicts Persistent Depression in Early Rheumatoid Arthritis: Results from the Ontario Best Practices Research Initiative

Kuriya, Bindee; Joshi, Raman; Movahedi, Masoud; Rampakakis, Emmanouil; Sampalis, John S.; Bombardier, Claire

doi:10.3899/jrheum.171195

Cited by 14 publications

(16 citation statements)

References 21 publications

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“…Moreover, Kuriya et al . [32] demonstrated a significant association between high continuous disease activity, measured by the Clinical Disease Activity Index, and persistent depression.…”

Section: Depression and The Impact On Rheumatoid Arthritis Disease Comentioning

confidence: 99%

Depression and the risk of rheumatoid arthritis

Vallerand¹,

Patten²,

Barnabé

2019

Current Opinion in Rheumatology

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Purpose of review Rheumatoid arthritis (RA) is associated with negative changes in mental health. This is generally attributed to symptoms of inflammation and the adverse impact of RA on quality of life and functioning. Until recently, causal pathways in the opposite direction have not been fully appreciated. This review examines the recent literature on the risk of RA associated with depression. Recent findings Current literature links depression with an increased risk of RA and with a more detrimental disease course. These effects are likely to be partially mediated by negative effects of depression on coping with RA and on factors such as medication adherence, both of which lead to poorer disease outcomes. Growing evidence also suggests that inflammation is central both to depression and RA and may account for some of the complex interplay between these conditions. Summary Awareness of a bidirectional relationship between depression and RA through a biopsychosocial framework may assist clinicians in maintaining an appropriate index of suspicion about the co-occurrence of these conditions. This review also suggests an important need for integration of rheumatologic and mental health services and generates hypotheses for future research towards a better understanding of both depression and RA.

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“…Moreover, Kuriya et al . [32] demonstrated a significant association between high continuous disease activity, measured by the Clinical Disease Activity Index, and persistent depression.…”

Section: Depression and The Impact On Rheumatoid Arthritis Disease Comentioning

confidence: 99%

Depression and the risk of rheumatoid arthritis

Vallerand¹,

Patten²,

Barnabé

2019

Current Opinion in Rheumatology

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“…These findings extend previous papers showing that CDAI scores were significantly associated with depression ratings. [64][65][66] In another study in RA, patients with depression showed higher ratings on TJCs, EGA, PGA, DAS-28, SDAI, and CDAI. 65 A cross-sectional study performed in The Kenyatta National Hospital showed that depression was accompanied by increased CDAI scores and lowered quality of life.…”

Section: Discussionmentioning

confidence: 99%

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Hn¹,

Ha²,

Sq³

et al. 2021

Preprint

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Background. Rheumatoid arthritis (RA) is a chronic inflammatory and autoimmune disorder which affects the joints in the wrists, fingers, and knees. RA is often associated with depressive and anxiety symptoms as well as chronic fatigue syndrome (CFS)-like symptoms.Aim. To examine the association between depressive symptoms (measured with the Beck Depression Inventory, BDI), anxiety (Hamilton Anxiety Rating Scale, HAMA), and CFS-like (Fibro-fatigue Scale) symptoms and immune-inflammatory, autoimmune, and endogenous opioid system (EOS) markers, and lactosylceramide in RA. Methods. The serum biomarkers were assayed in fifty-nine RA and fifty-nine patients without increased psychopathology (PP) and fifty healthy controls.Results. There were highly significant correlations between the BDI, FF, and HAMA scores and severity of RA, as assessed with the DAS28-4, clinical and disease activity indices, the number of tenders and swollen joints, and patient and evaluator global assessment scores. A common latent vector (reflective model) could be extracted from the PP and RA-severity scales, which showed excellent psychometric properties. Partial least squares analysis showed that 69.7% of the variance in this common core underpinning PP and RA symptoms could be explained by the regression on immune-inflammatory pathways, rheumatoid factor, anti-citrullinated protein antibodies, CD17, and mu-opioid receptor levels. Conclusions. Depression, anxiety, and CFS-like symptoms due to RA are reflective manifestations of the phenome of RA and are mediated via the effects of the same immune-inflammatory, autoimmune, and EOS pathways and lactosylceramide that underpin the pathophysiology of RA. These PP symptoms are clinical manifestations of the pathophysiology of RA.

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“…From a neurobiological perspective, reduced expression of BDNF, but not serum levels of pro-inflammatory cytokines (59) or TNF-α (57), has been found in depressed patients with RA with respect to subjects without depression. In contrast, other studies have documented a relationship between MDD and the inflammatory state, defined by plasma CRP levels (73) or indirectly via clinical indices of RA activity (74). The implication of over-inflammation in the onset of mood symptoms in RA is also supported by the evidence of alterations in the micro-structure of brain white matter in subjects with RA and comorbid depression as a result of vasculitis, ischemic brain lesions, and dots of demyelination (75).…”

Section: Autonomic Nervous System and Affective Disorders In Rheumatomentioning

confidence: 99%

The Link Between Autonomic Nervous System and Rheumatoid Arthritis: From Bench to Bedside

et al. 2020

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Neuronal stimulation is an emerging field of research focused on the management and treatment of various diseases through the reestablishment of physiological homeostasis. Electrical vagus nerve stimulation has recently been proposed as a revolutionary therapeutic option for rheumatoid arthritis (RA) in combination with or even as a replacement for conventional and biological drugs. In the past few years, disruption of the autonomic system has been linked to RA onset and activity. Novel research on the link between the autonomic nervous system and the immune system (immune-autonomics) has paved the way for the development of innovative RA management strategies. Clinical evidence supports this approach. Cardiovascular involvement, in terms of reduced baroreflex sensitivity and heart rate variability-derived indices, and mood disorders, common comorbidities in patients with RA, have been linked to autonomic nervous system dysfunction, which in turn is influenced by increased levels of circulating pro-inflammatory cytokines. This narrative review provides an overview of the autonomic nervous system and RA connection, discussing most of the common cardiac and mental health-related RA comorbidities and their potential relationships to systemic and joint inflammation.

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High Disease Activity Is Associated with Self-reported Depression and Predicts Persistent Depression in Early Rheumatoid Arthritis: Results from the Ontario Best Practices Research Initiative

Cited by 14 publications

References 21 publications

Depression and the risk of rheumatoid arthritis

Depression and the risk of rheumatoid arthritis

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

The Link Between Autonomic Nervous System and Rheumatoid Arthritis: From Bench to Bedside

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