High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I

Tan, Joanne; Prosser, Hamish; Dunn, Louise; Vanags, Laura Z.; Ridiandries, Anisyah; Tsatralis, Tania; Lecce, Laura; Clayton, Zoe; Yuen, Sui Ching G.; Robertson, S. E. J.; Lam, Yuen Ting; Celermajer, David S.; Ng, M.; Bursill, Christina A.

doi:10.2337/db15-1668

Cited by 40 publications

(56 citation statements)

References 50 publications

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“…is result is similar to Netzer's finding [20]. HDL-C plays an important role in cardiovascular health, such as increasing angiogenesis [56], and protective effects of CAD [57]. Endurance exercise could elevate plasma HDL-C [58].…”

Section: Discussionsupporting

confidence: 86%

Effects of Living High-Training Low and High on Body Composition and Metabolic Risk Markers in Overweight and Obese Females

Gao

Zhang

et al. 2020

BioMed Research International

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This study examined the effects of 4 weeks of living high-training low and high (LHTLH) under moderate hypoxia on body weight, body composition, and metabolic risk markers of overweight and obese females. Nineteen healthy overweight or obese females participated in this study. Participants were assigned to the normoxic training group (NG) or the LHTLH group (HG). The NG participants lived and trained at sea level. The HG participants stayed for approximately 10 hours in a simulated 2300 m normobaric state of hypoxia for six days a week and trained for 2 hours 3 times a week under the same simulated hypoxia. The interventions lasted for 4 weeks. All groups underwent dietary restriction based on resting metabolic rate. The heart rate of the participants was monitored every ten minutes during exercise to ensure that the intensity was in the aerobic range. Compared with the preintervention values, body weight decreased significantly in both the NG and the HG (−8.81 ± 2.09% and −9.09 ± 1.15%, respectively). The fat mass of the arm, leg, trunk, and whole body showed significant reductions in both the NG and the HG, but no significant interaction effect was observed. The percentage of lean soft tissue mass loss in the total body weight loss tended to be lower in the HG (27.61% versus 15.94%, P=0.085). Between the NG and the HG, significant interaction effects of serum total cholesterol (−12.66 ± 9.09% versus −0.05 ± 13.36%,) and apolipoprotein A1 (−13.66 ± 3.61% versus −5.32 ± 11.07%, P=0.042) were observed. A slight increase in serum high-density lipoprotein cholesterol (HDL-C) was observed in the HG (1.12 ± 12.34%) but a decrease was observed in the NG (−11.36 ± 18.91%). The interaction effect of HDL-C between NG and HG exhibited a significant trend (P=0.055). No added effects on serum triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), or APO-B were observed after 4 weeks of LHTLH. In conclusion, 4 weeks of LHTLH combined with dietary restriction could effectively reduce the body weight and body fat mass of overweight and obese females. Compared with training and sleeping under normoxia, no additive benefit of LHTLH on the loss of body weight and body fat mass was exhibited. However, LHTLH may help to relieve the loss of lean soft tissue mass and serum HDL-C.

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Section: Discussionsupporting

confidence: 86%

Effects of Living High-Training Low and High on Body Composition and Metabolic Risk Markers in Overweight and Obese Females

Gao

Zhang

et al. 2020

BioMed Research International

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“…In addition, serum HDL cholesterol correlated negatively with subepidermal OR‐T4MBM, while current alcohol consumption correlated positively with IENFD and negatively with subepidermal OR‐T4MBM among patients with diabetes. Although these unexpected findings warrant further investigation in a larger study, it might be worth noting that HDL can augment ischemia‐induced physiological angiogenesis and inhibit inflammation‐driven pathological angiogenesis through its receptor, and can regulate key angiogenic mediators including VEGF, thereby modulating angiogenesis in inflammatory diseases such as type 2 diabetes.…”

Section: Discussionmentioning

confidence: 92%

Cutaneous microangiopathy in patients with type 2 diabetes: Impaired vascular endothelial growth factor expression and its correlation with neuropathy, retinopathy and nephropathy

Sugimoto

Murakami

Deguchi

et al. 2019

J of Diabetes Invest

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Aims/Introduction To examine the three‐dimensional morphology and vascular endothelial growth factor (VEGF) expression of skin microvasculature in patients with type 2 diabetes in relation to neuropathy, retinopathy and nephropathy. Materials and Methods The present study enrolled 17 individuals with type 2 diabetes and 16 without. Skin sections were double‐immunostained for type IV collagen and VEGF‐A or protein gene product 9.5. Projected images from confocal microscopy served to quantify the occupancy rate of subepidermal type IV collagen‐immunoreactive microvascular basement membrane area (OR‐T4MBM), subepidermal VEGF‐A‐immunoreactive area and the VEGF/T4MBM ratio, as well as the protein gene product 9.5‐immunoreactive intraepidermal nerve fiber density. Reduced intraepidermal nerve fiber density was applied for the diagnosis of neuropathy, fundic ophthalmoscopy and fluorescein angiography for retinopathy, and microalbuminuria or persistent proteinuria for nephropathy. Results A total of 12 patients with diabetes had neuropathy, 10 had retinopathy and eight had nephropathy. Regardless of the presence or absence of neuropathy, retinopathy or nephropathy, OR‐T4MBM was significantly increased in patients with diabetes compared with individuals without diabetes. In contrast, VEGF/T4MBM ratio was significantly decreased in those with neuropathy and retinopathy, as well as in those with and without nephropathy, whereas a trend toward a decreased VEGF/T4MBM ratio was seen in patients without retinopathy, as compared with individuals without diabetes. Conclusions The present study is the first report to show that cutaneous microangiopathy, as indicated by subepidermal microvascular proliferation and impaired VEGF expression, appears to occur before the development of overt clinical neuropathy, retinopathy or nephropathy in patients with type 2 diabetes.

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“…Quantitative real-time PCR was performed for Pparα, Pparδ, Pparγ, Pgc-1α, Tgf-β1, Ccl2, Cd68, Per2 and Cyclophilin using primers designed previously [19,[57][58][59]. Primers were designed for C/ebpα (F: 5 -TCGGTGGACAAGAACAGCAA-3 , R: 5 -CGTTGCGCTGTTTGGCTTTA-3 ), Adipoq (F: 5 -CCCCAATGTCCCATTCGCTT-3 , R: 5 -GAACGGCCTTGTCCTTCTTG-3 ) and Ucp1 (F: 5 -GGCATTCAGAGGCAAATCAGC-3 , R: 5 -CTTGCTTCCAAAGAGGCAGGTG-3 ) by aligning Homo sapiens, Mus musculus and Rattus norvegicus sequences and generated based on the overlapping consensus sequences using Primer Blast.…”

Section: Gene Expression Analysismentioning

confidence: 99%

High-Energy Diet and Shorter Light Exposure Drives Markers of Adipocyte Dysfunction in Visceral and Subcutaneous Adipose Depots of Psammomys obesus

Tan

Nankivell

Bilu

et al. 2019

IJMS

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Dysfunctional adipose tissue phenotype underpins type 2 diabetes mellitus (T2DM) development. The disruption of circadian rhythms contributes to T2DM development. We investigated the effects of high-energy diet and photoperiod length on visceral and subcutaneous adipose tissue phenotype. Psammomys obesus sand rats exposed to neutral (12 light:12 dark) or short (5 light:19 dark) photoperiod were fed a low-(LE) or high-(HE) energy diet. The HE diet and/or short photoperiod reduced subcutaneous expression of adipocyte differentiation/function markers C/ebpα, Pparδ, Pparγ and Adipoq. Visceral Pparα levels were elevated in the 5:19HE group; however, the HE diet and/or short photoperiod decreased visceral Pparγ and Adipoq expression. 5:19HE animals had elevated Ucp1 yet lower Pgc-1α levels. The HE diet increased visceral Tgf-β1, Ccl2 and Cd68 levels, suggestive of a pro-inflammatory state. Daily visceral rhythms of these genes were affected by a short photoperiod and/or HE diet. The 12:12HE, 5:19LE or 5:19HE animals had a higher proportion of larger adipocytes, indicating increased adipocyte hypertrophy. Collectively, the HE diet and/or shorter light exposure drives a dysfunctional adipose tissue phenotype. Daily rhythms are affected by a short photoperiod and HE diet in a site-specific manner. These findings provide mechanistic insight on the influence of disrupted circadian rhythms and HE diet on adipose tissue phenotype.

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High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I

Cited by 40 publications

References 50 publications

Effects of Living High-Training Low and High on Body Composition and Metabolic Risk Markers in Overweight and Obese Females

Effects of Living High-Training Low and High on Body Composition and Metabolic Risk Markers in Overweight and Obese Females

Cutaneous microangiopathy in patients with type 2 diabetes: Impaired vascular endothelial growth factor expression and its correlation with neuropathy, retinopathy and nephropathy

High-Energy Diet and Shorter Light Exposure Drives Markers of Adipocyte Dysfunction in Visceral and Subcutaneous Adipose Depots of Psammomys obesus

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