2018
DOI: 10.1038/s41598-018-19568-8
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Recent evidence suggests that oxidative stress can play a role in the pathogenesis and the progression of prostate cancer (PCa). Reactive oxygen species (ROS) generation is higher in PCa cells compared to normal prostate epithelial cells and this increase is proportional to the aggressiveness of the phenotype. Since high density lipoproteins (HDL) are known to exert antioxidant activities, their ability to reduce ROS levels and the consequent impact on cell proliferation was tested in normal and PCa cell lines… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
22
0
1

Year Published

2018
2018
2024
2024

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 29 publications
(24 citation statements)
references
References 55 publications
(56 reference statements)
1
22
0
1
Order By: Relevance
“…[ 24 ] HDL cholesterol perhaps plays a role in antioxidative activities and modulates oxidative stress, as well as protects cells against the adverse effect of LDL cholesterol oxidation. [ 25 ] Dyslipidemia may occur in insulin resistance and metabolic syndrome, which have been significant risk factors for CRC. [ 26 ]…”
Section: Discussionmentioning
confidence: 99%
“…[ 24 ] HDL cholesterol perhaps plays a role in antioxidative activities and modulates oxidative stress, as well as protects cells against the adverse effect of LDL cholesterol oxidation. [ 25 ] Dyslipidemia may occur in insulin resistance and metabolic syndrome, which have been significant risk factors for CRC. [ 26 ]…”
Section: Discussionmentioning
confidence: 99%
“…In a study performed on PCa cell lines, the proliferative activity of LNCap cells exposed to low concentrations of H2O2 increases. Still, it returns to the pretreatment level after continued exposure to the antioxidant HDL that can counteract the elevated ROS induced by H2O2 [ 62 ]. Furthermore, according to the redox imbalance of tumor cells, we can filter several indicators including increased 8-hydroxydeoxyguanosine or F2-isoprostane in urine and decreased levels of the antioxidant-tocopherol or increased peroxide levels in serum as diagnosis and prognosis markers in PCa [ 63 ].…”
Section: Roles Of Ros Molecules In Pcamentioning
confidence: 99%
“…Further functional analyzes showed that HDL from Mb pre-MDT has also a lower antioxidant activity against the oxidative stress promoted by H 2 O 2 when compared to HDL from HC. This is also possibly linked with the lower amount of ApoA-I, since previous works showed that the prevention of oxidative stress by HDL is mainly performed by ApoA-I and PON-1 [72,73] and data showed no differences on PON-1 plasma levels between patients and HC. When evaluating the inflammatory activity of HDL, it was revealed that this lipoprotein from Mb pre-MDT patients increased the expression of IL-6 upon LPS stimulation compared to HDL from HC, but it was unable to modulate the basal expression of MCP-1 on endothelial cells.…”
Section: Discussionmentioning
confidence: 87%