High-density lipoprotein: Quality versus quantity in type 2 diabetes mellitus

Bitla, AparnaR; Naresh, Sriram; Sachan, Alok

doi:10.4103/jcsr.jcsr_108_19

Cited by 3 publications

(8 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultracentrifugation constitutes the gold standard for lipoprotein separation but is not relevant for the clinical laboratory because is expensive and technically complex [49]. High-performance liquid chromatography (HPLC) allows the simultaneous separation of lipoproteins and quantification of their cholesterol content, but their use is applied only in specialized laboratories [47].…”

Section: Methods Of Hdl Measurement In the Laboratorymentioning

confidence: 99%

“…T2DM is a major public health disorder characterized by inflammation and altered lipids circulation [49,85]. Patients with T2DM mostly suffer from obesity, which is why they have an increased risk for CVD.…”

Section: Diabetes Mellitus Typementioning

confidence: 99%

“…In a physiological state, Apo M enhances S1P in HDLs, which results in an increased production of endothelial NO. In T2DM, the decrease of S1P promotes the proatherogenic effect, as it determines a lower production of NO [49,85]. Diabetic subjects show a decrease in NO bioavailability: such reduction of NO production leads to an inhibition of antioxidant mechanisms, which leads to an increase of oxidative stress [2,5].…”

Section: Diabetes Mellitus Typementioning

confidence: 99%

“…In addition, in patients with T2DM, the reduction of PAF-AH and PON1 activity impairs their function as LDL antioxidative agents and, at the same time, seems to alter the antioxidant capacity of HDLs [2,49,59,62].…”

Section: Diabetes Mellitus Typementioning

confidence: 99%

“…Moreover, the presence of chronic inflammation in T2DM increases the levels of SSA. This alteration in HDL proteome contributes to the acceleration of the clearance of these particles from plasma [5,45,49,85].…”

Section: Diabetes Mellitus Typementioning

confidence: 99%

See 4 more Smart Citations

HDL Dysfunctionality: Clinical Relevance of Quality Rather Than Quantity

et al. 2021

View full text Add to dashboard Cite

High-density lipoproteins (HDLs) represent a class of lipoproteins very heterogeneous in structure, composition, and biological functions, which carry out reverse cholesterol transport, antioxidant, anti-inflammatory, antithrombotic, and vasodilator actions. Despite the evidence suggesting a clear inverse relationship between HDL cholesterol (HDL-c) concentration and the risk for cardiovascular disease, plasma HDL cholesterol levels do not predict the functionality and composition of HDLs. The importance of defining both the amount of cholesterol transported and lipoprotein functionality has recently been highlighted. Indeed, different clinical conditions such as obesity, diabetes mellitus type 2 (T2DM), and cardiovascular disease (CVD) can alter the HDL functionality, converting normal HDLs into dysfunctional ones, undergoing structural changes, and exhibiting proinflammatory, pro-oxidant, prothrombotic, and proapoptotic properties. The aim of the current review is to summarize the actual knowledge concerning the physical–chemical alteration of HDLs related to their functions, which have been found to be relevant in several pathological conditions associated with systemic inflammation and oxidative stress.

show abstract

Section: Methods Of Hdl Measurement In the Laboratorymentioning

confidence: 99%

Section: Diabetes Mellitus Typementioning

confidence: 99%

Section: Diabetes Mellitus Typementioning

confidence: 99%

Section: Diabetes Mellitus Typementioning

confidence: 99%

Section: Diabetes Mellitus Typementioning

confidence: 99%

See 3 more Smart Citations

HDL Dysfunctionality: Clinical Relevance of Quality Rather Than Quantity

et al. 2021

View full text Add to dashboard Cite

show abstract

HDL Function in Diabetes

Gluba-Brzózka

Rysz-Górzyńska

Rysz

2023

Contemporary Diabetes

View full text Add to dashboard Cite

High-density lipoprotein: Quality is more important than quantity!

2022

View full text Add to dashboard Cite

High density lipoproteins (HDLs) are complex lipid carriers which replace their own structures and functions according to different conditions including healthy or pathological status. HDL has substantial roles in reverse cholesterol transport system for regulation of lipid metabolism. Also HDL has many functions such as antiinflammation, antioxidation, antithrombotic and vasodilator actions. However, these functions may be compromised under pathological conditions. Nowadays, it’s known that the function of HDL is more important than it’s dose for preventing against cardiovascular diseases. This review mostly summarizes available information of HDL structure, metabolism and the real information related to the physicochemical changes of HDLs causing their different functions. Also HDLs, that lost their protective functions have been associated with oxidative stress and systemic inflammation diseases.

show abstract

High-density lipoprotein: Quality versus quantity in type 2 diabetes mellitus

Cited by 3 publications

References 73 publications

HDL Dysfunctionality: Clinical Relevance of Quality Rather Than Quantity

HDL Dysfunctionality: Clinical Relevance of Quality Rather Than Quantity

HDL Function in Diabetes

High-density lipoprotein: Quality is more important than quantity!

Contact Info

Product

Resources

About