High-Density Lipoprotein Cholesterol Is a Favorable Prognostic Factor and Negatively Correlated with C-Reactive Protein Level in Non-Small Cell Lung Carcinoma

Abstract

BackgroundAlthough the alterations of lipid profile in lung cancer have been documented, the prognostic value of serum HDL-C level and its correlation with inflammation in NSCLC remain unknown.Subjects and MethodsLevels of preoperative serum lipid concentrations (including HDL-C, LDL-C, TC, and TG) and the inflammatory biomarker C-reactive protein level (CRP) were retrospectively analyzed in 228 patients with NSCLC and in 300 healthy controls. The serum lipid levels in these two populations were compared. Univariate and multivariate cox hazards analyses were performed to investigate the prognostic value of serum lipid levels in NSCLC. The correlation between CRP and lipid profile were also analyzed.ResultsCompared with those in normal controls, the serum HDL-C, LDL-C, and TC levels were statistically decreased and the TG levels were significantly increased in 228 NSCLC patients. The patients with decreased levels of HDL-C had significantly lower 5-year survival rates than those with normal HDL-C, not only in the whole NSCLC cohort but also in the subgroups stratified according to the disease T, N classifications, and metastasis, whereas the other lipid components were not independent prognostic factors for NSCLC. Of the lipid components, a lower HDL-C level was observed more often in patients with a high CRP level than in those with a normal CRP level. Spearman’s rank correlation analysis revealed that the HDL-C level presented a negative correlation with the CRP level (r = −0.360, p<0.001).ConclusionsA decreased level of preoperative HDL-C was found to be associated with poor survival in patients with NSCLC. Serum HDL-C level may be a clinical prognosis factor for NSCLC patients. In addition, a negative correlation was present between the levels of HDL-C and CRP, the well-known inflammation biomarker.

Low serum cholesterol levels predict inferior prognosis and improve NCCN‐IPI scoring in diffuse large B cell lymphoma

“…In consistent with our results on cancer prognosis, a prospective cohort study including 30 179 male and 26 005 female participants who were followed up for 9 years presented that low serum cholesterol was associated with increased risk for overall cancer mortality (HR = 1.52; 95% CI: 1.06–2.18) . Previous epidemiological studies also provided that decreased level of HDL‐C could be an easily measured predictor for inferior prognosis in breast, prostate cancer and non‐small cell lung carcinoma . Wang et al .…”

Prognostic value of circulating C-reactive protein levels in patients with non-small cell lung cancer: A systematic review with meta-analysis

“…After a series of screening based on the inclusion/exclusion criteria mentioned above, 8 publications were eventually eligible for the meta-analysis. [26,29,[33][34][35][36][37][38] All these studies were published in peer-reviewed journals.…”

“…Some studies reported that the high expression of serum CRP was correlated with unfavorable prognosis, [26,27] while some others did not show any significant link between CRP and NSCLC survival. [28,29] In this study, we performed an updated meta-analysis to give a comprehensive evaluation on the prognostic role of CRP in NSCLC.…”

Prognostic Value of Circulating Lipoprotein in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma

“…Several studies [11][12][13] have reported a significant inverse relation between HDL and disease prognosis at many sites. As shown in a study by Chi et al [11]., high HDL was an independent prognostic factor of PFS in lung adenocarcinoma patients. Another study by Wolfe et al [14].…”

“…Several studies have reported a significant inverse relation between lipoproteins and the risk of cancer at multiple sites [8][9][10]. Furthermore, recent studies have demonstrated that HDL was a favorable prognostic marker in several cancers, including cancers of the lung, breast and stomach [11][12][13][14]. Studies have also suggested that LDL enhances the colorectal cancer progression via reactive oxygen species (ROS) and the mitogen-activated protein kinase (MAPK) pathway [13].…”