2011
DOI: 10.1016/j.ygeno.2011.07.007
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Abstract: We have developed a new generation of genome-wide DNA methylation BeadChip which allows high-throughput methylation profiling of the human genome. The new high density BeadChip can assay over 480K CpG sites and analyze twelve samples in parallel. The innovative content includes coverage of 99% of RefSeq genes with multiple probes per gene, 96% of CpG islands from the UCSC database, CpG island shores and additional content selected from whole-genome bisulfite sequencing data and input from DNA methylation exper… Show more

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Cited by 1,433 publications
(1,383 citation statements)
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References 42 publications
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“…DNA was whole-genome amplified, enzymatically fragmented, purified, and applied to the Illumina Infinium HumanMethylation450 BeadChips (Illumina, San Diego, CA) according to the Illumina methylation protocol [11,12]. Both EPIC and 450K chips were analyzed using the Illumina Hi-Scan system.…”
Section: Methodsmentioning
confidence: 99%
“…DNA was whole-genome amplified, enzymatically fragmented, purified, and applied to the Illumina Infinium HumanMethylation450 BeadChips (Illumina, San Diego, CA) according to the Illumina methylation protocol [11,12]. Both EPIC and 450K chips were analyzed using the Illumina Hi-Scan system.…”
Section: Methodsmentioning
confidence: 99%
“…In this context, the Infinium 450k array represents the most widely used platform and allows the methylation analysis of more than 450 000 cytosine residues in the human genome. The corresponding probes have been selected to cover both general and specific features that are commonly linked to epigenetic gene regulation (Bibikova et al ., 2011). …”
Section: Introductionmentioning
confidence: 99%
“…The primary alternate approach to methylation analysis that does not use NGS is high density microarrays (Bibikova et al 2009;Bibikova et al 2011). These micorarrays are adaptations of SNP microarrays widely used in the genetics field, coupled with bisulfite conversion.…”
Section: Methylation Microarraysmentioning
confidence: 99%