2016
DOI: 10.1111/dote.12308
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Abstract: Nonerosive reflux disease (NERD) is commonly diagnosed in patients with symptoms of reflux. The aim of the present study was to determine whether high-definition endoscopy (HD) plus equipped with the iScan function or chromoendoscopy with Lugol's solution might permit the differentiation of NERD patients from those without reflux symptoms, proven by targeted biopsies of endoscopic lesions. A total of 100 patients without regular intake of proton pump inhibitors and with a normal conventional upper endoscopy we… Show more

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Cited by 13 publications
(18 citation statements)
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“…Similar minimal changes in the squamocolumnar junction of the esophagus have been reported in other studies comparing the utility of i-scan, FICE with that of WLE [6,7,[25][26][27][28]. In all these trials, image-enhanced endoscopy increased the diagnostic yield of reflux esophagitis by detecting, in accordance with our results, mucosal and vascular alterations at the distal esophagus adjacent to the Z-line.…”
Section: Discussionsupporting
confidence: 91%
“…Similar minimal changes in the squamocolumnar junction of the esophagus have been reported in other studies comparing the utility of i-scan, FICE with that of WLE [6,7,[25][26][27][28]. In all these trials, image-enhanced endoscopy increased the diagnostic yield of reflux esophagitis by detecting, in accordance with our results, mucosal and vascular alterations at the distal esophagus adjacent to the Z-line.…”
Section: Discussionsupporting
confidence: 91%
“…When minimal changes were analyzed by using more than one endoscopic finding, same results were found between the two groups with sensitivity of 87.5% and positive predictive value of 85.7%. This was consistent with Rey JW et al’s result [18] but not that of Netinatsunton et al’s study [20]. Rey and his colleges performed high definition endoscopy with i-scan imaging and Lugol’s solution for the detection of inflammation in NERD patients.…”
Section: Discussionsupporting
confidence: 90%
“…It is software-based real-time modification of image sharpness, hue and contrast provides high resolution images that improve identification of minimal change lesions [18]. Kim et al [19] showed that i-scan endoscopy identified more minimal changes than conventional endoscopy and therefore increased the efficiency of GERD diagnosis.…”
Section: Introductionmentioning
confidence: 99%
“…One study conducted in Thailand in a small number of patients showed that SE detected more MCE in patients with GERD symptoms than in a control group [ 20 ]. Another study by Rey JW et al showed SE detected more MCE in patients with GERD symptoms than in controls with a sensitivity of 82.5 % to detect GERD confirmed by histology [ 21 ].…”
Section: Introductionmentioning
confidence: 99%