High Concentrations of Uric Acid Inhibit Angiogenesis via Regulation of the Krüppel-Like Factor 2-Vascular Endothelial Growth Factor-A Axis by miR-92a

Yu, Shandong; Hong, Quan; Wang, Yuanda; Hou, Kai; Wang, Liyuan; Zhang, Yang; Fu, Bo; Zhou, Yunan; Zheng, Wei; Chen, Xiangmei; Wu, Di

doi:10.1253/circj.cj-15-0283

Cited by 32 publications

(31 citation statements)

References 32 publications

(13 reference statements)

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“…Experimental studies have suggested that UA itself can promote endothelial dysfunction by several biological processes, including glomerular hypertension, 28 inflammatory action, 29 oxidative stress, 30 and inhibition of angiogenesis. 31 It has also been acknowledged that albuminuria reflects systemic endothelial dysfunction. 32 The pathophysiology of the influence of SUA on albuminuria requires further exploration.…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community　– The Hisayama Study –

Takae

Nagata

Hata

et al. 2016

Circ J

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Background: Growing evidence suggests that high serum uric acid (SUA) levels are causally related to increased risk of chronic kidney disease (CKD). However, few studies have investigated the influence of elevated SUA levels on the incidence of kidney dysfunction and albuminuria separately in community-based populations. Methods and Results:A total of 2,059 community-dwelling Japanese subjects aged ≥40 years without CKD were followed for 5 years. CKD was defined as kidney dysfunction (estimated glomerular filtration rate <60 ml/min/1.73 m 2 ) or albuminuria (urine albumin-creatinine ratio ≥30 mg/g). The odds ratio (OR) for the development of CKD was estimated according to quartiles of SUA (≤4.0, 4.1-4.9, 5.0-5.8, and ≥5.9 mg/dl). During the follow-up, 396 subjects developed CKD, of whom 125 had kidney dysfunction and 312 had albuminuria. The multivariable-adjusted risk of developing CKD increased with higher SUA levels (OR 1. Conclusions:Higher SUA levels were a significant risk factor for the development of both kidney dysfunction and albuminuria in a general Japanese population. (Circ J 2016; 80: 1857 -1862

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Section: Discussionmentioning

confidence: 99%

Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community　– The Hisayama Study –

Takae

Nagata

Hata

et al. 2016

Circ J

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“…17,38,39 Moreover, another study demonstrated that Kruppel-like factor-2 was a target of miR-92a and that Kruppellike factor-2 binds the vascular endothelial growth factor-A promoter to inhibit EC angiogenesis in vitro. 40 Therefore, miR-92a inhibition may be a new atheroprotective strategy.…”

Section: Discussionmentioning

confidence: 99%

Circulating miR-92a expression level in patients with essential hypertension: a potential marker of atherosclerosis

Huang

Tang²,

Ji-yan

et al. 2016

J Hum Hypertens

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MicroRNAs (miRs) are key posttranscriptional regulators of gene expression in all eukaryotic cells and have a vital role in the evolution of hypertension and cardiovascular remodelling and, therefore, have emerged as potential biomarkers for cardiovascular disease. We assessed 240 participants, including 60 healthy volunteers with normal carotid intima-media thickness (nCIMT), 60 healthy volunteers with increased CIMT (iCIMT), 60 hypertensive patients with nCIMT and 60 hypertensive patients with iCIMT. All patients underwent measurements of CIMT, carotid-femoral pulse wave velocity (cfPWV) and ambulatory blood pressure (BP) monitoring. Plasma miR-92a expression was quantified by real-time reverse transcription PCR. Correlations between miR-92a expression and BP parameters, CIMT and cfPWV were assessed using the Spearman correlation coefficient. We observed the lowest miR-92a expression (24.59±1.30 vs 27.76±2.13 vs 29.29±1.89 vs 33.76±2.08; P<0.001) in healthy controls with nCIMT, followed by healthy controls with iCIMT, then hypertensive patients with nCIMT and the highest expression in hypertensive patients with iCIMT. Additionally, MiR-92a levels showed a significant positive correlation with 24-h mean systolic BP (r=0.807, P<0.001), 24-h mean diastolic BP (r=0.649, P<0.001), 24-h mean pulse pressure (PP) (r=0.697, P<0.001), 24-h daytime PP (r=0.654, P<0.001), 24-h nighttime PP (r=0.573, P<0.001), CIMT (r=0.571, P<0.001) and cfPWV (r=0.601, P<0.001). Our data present significant evidence that circulating miR-92a represents a potential noninvasive atherosclerosis marker in essential hypertensive patients.

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“…UA is associated with impaired endothelium‐mediated relaxation and vascular stiffness . Hyperuricemia may represent a marker or an independent risk factor for cardiovascular disease, including chronic kidney disease, in addition to hypertension, diabetes, and obesity . In the DETECT study, serum UA represents 1 of the 6 non‐echocardiographic variables to evaluate individual risk of pulmonary arterial hypertension development in SSc patients .…”

Section: Discussionmentioning

confidence: 99%

Serum level of endostatin and digital ulcers in systemic sclerosis patients

Gigante

Margiotta

Navarini

et al. 2018

International Wound Journal

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Patients with systemic sclerosis (SSc) are at a high risk of the development of ischaemic digital ulcers (DUs) that can be complicated with infections, gangrene, and osteomyelitis. The aim of this study is to evaluate the role of endostatin in scleroderma DUs.In total, 90 SSc patients were enrolled in this study. Serum endostatin levels and DU assessment were determined in all SSc patients. The serum levels of endostatin significantly increased with progression of capillaroscopic damage (P < .01). The serum levels of endostatin are significantly (P < .05) higher in SSc patients with new DUs than in SSc patients without new DUs (127 ± 31.1 ng/mL vs 116.3 ± 39.7 ng/mL). The Receiver Operating Characteristic (ROC) curves demonstrated good accuracy of new DU prediction for the serum level of endostatin (0.70, P < .01 [95% confidence interval (CI) 0.59-0.81]). Using a cut-off value of 116 ng/mL, the odds ratio was 2.609 (CI 1.075-6.330, P < .05). The serum levels of endostatin are significantly (P < .01) higher in SSc patients with infected DUs than in SSc patients without infected DUs (139.2 [114.6-340.91] ng/mL vs 117.5 [64.3-163.9] ng/mL). Serum levels of endostatin are higher in patients with DUs, especially in those with infected DUs.

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High Concentrations of Uric Acid Inhibit Angiogenesis via Regulation of the Krüppel-Like Factor 2-Vascular Endothelial Growth Factor-A Axis by miR-92a

Cited by 32 publications

References 32 publications

Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community　– The Hisayama Study –

Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community　– The Hisayama Study –

Circulating miR-92a expression level in patients with essential hypertension: a potential marker of atherosclerosis

Serum level of endostatin and digital ulcers in systemic sclerosis patients

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High Concentrations of Uric Acid Inhibit Angiogenesis via Regulation of the Krüppel-Like Factor 2-Vascular Endothelial Growth Factor-A Axis by miR-92a

Cited by 32 publications

References 32 publications

Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community – The Hisayama Study –

Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community – The Hisayama Study –

Circulating miR-92a expression level in patients with essential hypertension: a potential marker of atherosclerosis

Serum level of endostatin and digital ulcers in systemic sclerosis patients

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Product

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Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community　– The Hisayama Study –

Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community　– The Hisayama Study –