2008
DOI: 10.1111/j.1471-4159.2008.05415.x
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Abstract: Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer’s disease (AD)-like dementia but the underlying mechanisms remain unknown. In this study, we evaluated the cognitive performance in rodent models of hypercholesterolemia in relation to neuroinflammatory changes and amyloid precursor protein (APP) processing, the two key parameters of AD pathogenesis. Groups of normal C57BL/6 and low density lipoprotein receptor (LDLR)-deficient mice were fed a high fat/cholesterol diet f… Show more

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Cited by 301 publications
(225 citation statements)
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“…This up-regulation increases soluble A␤ oligomers as well as deposited A␤ levels followed by memory deficit (7). The up-regulation of ␤-secretase was also reported in HFD-feeding mice from another laboratory (32) and consistently reported in AD cases by several previous studies (33)(34)(35). Thus, this phenomenon might represent the actual pathology of sporadic AD.…”
Section: Discussionmentioning
confidence: 67%
“…This up-regulation increases soluble A␤ oligomers as well as deposited A␤ levels followed by memory deficit (7). The up-regulation of ␤-secretase was also reported in HFD-feeding mice from another laboratory (32) and consistently reported in AD cases by several previous studies (33)(34)(35). Thus, this phenomenon might represent the actual pathology of sporadic AD.…”
Section: Discussionmentioning
confidence: 67%
“…It is well known that hyperlipidemia induces inflammation in the brain [5][6][7] and that hyperlipidemia exacerbates the ischemic brain damage that is linked to neuroinflammation [8,9] . There is also considerable evidence that hyperlipidemia contributes to the disruption of cerebrovascular reflexes and the breakdown of the blood-brain barrier [45,46] .…”
Section: Discussionmentioning
confidence: 99%
“…Although hyperlipidemia is not a direct predictor of stroke, half of stroke patients have hyperlipidemia [4] . Hyperlipidemia induces inflammation in the brain [5][6][7] and exacerbates ischemic brain damage [8,9] . Therefore, decreasing cholesterol and inflammation may be an effective therapeutic strategy for reducing the influences of both hyperlipidemia and ischemic stroke.…”
Section: Original Articlementioning
confidence: 99%
“…Elevated levels of cholesterol have been proposed as one of the midlife risk factors for developing Alzheimer's disease [2]. It has been shown that hypercholesterolemia induced by diet can produce neuroinflammation accompanied by cognitive deficit as well as changes in the processing of amyloid precursor protein (APP) one of the markers associate to Alzheimer's disease in C57BL/6 mice [3]. In apolipoprotein E ε3 and ε4 knock-in mice 44 -45 weeks of cholesterol enriched diet increases levels of brain cholesterol esters especially in APOE ε4 knock-in mice [4].…”
Section: Introductionmentioning
confidence: 99%