2013
DOI: 10.1155/2013/164653
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Abstract: The aim of the present work is to analyze the cerebrospinal fluid proteomic profile, trying to find possible biomarkers of the effects of hypertension of the blood to CSF barrier disruption in the brain and their participation in the cholesterol and β-amyloid metabolism and inflammatory processes. Cerebrospinal fluid (CSF) is a system linked to the brain and its composition can be altered not only by encephalic disorder, but also by systemic diseases such as arterial hypertension, which produces alterations in… Show more

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Cited by 16 publications
(12 citation statements)
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“…There are few reports on varying protein CSF profiles between WKY and SHR rats. One study (Gonzalez-Marrero I et al, 2013) reported lower levels of proteins and related this with the (dys)function of blood-CSF barrier (Transthyretin) in SHR compared to WKY. The same study also reported higher levels of blood plasma proteins (IgG, albumin and haptoglobin) and the proteins related with inflammation as a consequence of a leaky blood-CSF barrier in SHR.…”
Section: Discussionmentioning
confidence: 99%
“…There are few reports on varying protein CSF profiles between WKY and SHR rats. One study (Gonzalez-Marrero I et al, 2013) reported lower levels of proteins and related this with the (dys)function of blood-CSF barrier (Transthyretin) in SHR compared to WKY. The same study also reported higher levels of blood plasma proteins (IgG, albumin and haptoglobin) and the proteins related with inflammation as a consequence of a leaky blood-CSF barrier in SHR.…”
Section: Discussionmentioning
confidence: 99%
“…These observations suggest an intact BBB and BCSFB in SHR, as concentrations of these plasma proteins would expectedly be higher in case of a leaky barrier. Others did find differences in the protein composition of CSF between SHR and WKY, which includes a relatively low level of transthyretin [ 16 ]. This could reflect dysfunction of the choroid plexus in SHR, other than increased permeability.…”
Section: Discussionmentioning
confidence: 99%
“…Future studies should be larger and include analyses of possible confounders and to what extent pain and depression, e.g., may share inflammation as a common mediator 110. Determination of unique and common regressors may also be applicable for factors such as BMI, concomitant medication, and blood pressures 114. The comparisons with proteomic studies concerning neurodegenerative and psychiatric conditions made earlier may be biased since several of these studies have not determined the most important proteins using MVDA or similar techniques.…”
Section: Discussionmentioning
confidence: 99%