High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles

Kritchenkov, Andreii S.; Kurasova, Margarita N.; Godzishevskaya, Anastasia A.; Mitrofanova, Elizaveta S.; Egorov, Anton R.; Yagafarov, Niyaz Z.; Meza, Moises J. Ballesteros; Tskhovrebov, Alexander G.; Artemjev, Alexey A.; Andrusenko, Elena V.; Khrustalev, Victor N.

doi:10.1016/j.mencom.2021.07.022

Cited by 11 publications

(3 citation statements)

References 10 publications

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“…All of the above approaches are widely used in the chemistry of chitosan, but, among them, ionic gelation has an important advantage: this approach is very simple and does not require special equipment derivatives [ 49 ]. For example, in our previous works [ 50 , 51 ], the ionic gelation method allowed us to obtain several chitosan-derived nanoparticles with a unimodal size distribution. Using this previous experience, in our current work, we used ionic gelation with sodium tripolyphosphate to prepare nanoparticles of highly substituted chitosan derivatives of different molecular weights.…”

Section: Resultsmentioning

confidence: 99%

Benzothiazole Derivatives of Chitosan and Their Derived Nanoparticles: Synthesis and In Vitro and In Vivo Antibacterial Effects

Shakola,

Rubanik,

Rubanik

et al. 2023

Polymers

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In this work, we focused on synthesizing and assessing novel chitosan-based antibacterial polymers and their nanoparticles by incorporating benzothiazole substituents. The growing resistance to antibiotics has necessitated the search for alternative antimicrobial compounds. This study aimed to synthesize and evaluate chitosan-based polymers and nanoparticles with benzothiazole substituents for their antibacterial properties and toxicity. The benzothiazole derivatives of chitosan and their nanoparticles were synthesized through electrochemical coupling. The in vivo antibacterial efficacy was tested on white rats with induced peritonitis using a microbial suspension containing S. aureus and E. coli. Additionally, in vitro and in vivo toxicity assessments were conducted. The chitosan-based antibacterial systems showed significant in vivo antibacterial activity, surpassing that of unmodified chitosan and commercial antibiotics. Moreover, the toxicity studies revealed low toxicity levels of the synthesized derivatives, which did not differ significantly from native chitosan. The synthesized chitosan-based polymers and nanoparticles demonstrated potent antibacterial activity and low toxicity, highlighting their potential as effective alternatives to traditional antibiotics. Further investigations in pharmacology and preclinical trials are recommended to explore their application in clinical settings.

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Section: Resultsmentioning

confidence: 99%

Benzothiazole Derivatives of Chitosan and Their Derived Nanoparticles: Synthesis and In Vitro and In Vivo Antibacterial Effects

Shakola,

Rubanik,

Rubanik

et al. 2023

Polymers

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“…This illustrates that the incubation time also influences chitosan toxicity, while the toxicity of chitosan nanoparticles can be influenced by the concentration of exposure. 95 Toxicity testing of chitosan derivative in the form of pyridoxal chitosan nanoparticles did not show any potential toxicity in the MTT assay. This toxicity assessment was conducted by examining the cell viability percentage of the best nanoparticle formula at concentrations of 10, 300, and 3000 ppm, resulting in viability percentages of 98, 93, and 64%, respectively.…”

Section: Cell Linesmentioning

confidence: 93%

“…This illustrates that the incubation time also influences chitosan toxicity, while the toxicity of chitosan nanoparticles can be influenced by the concentration of exposure. 95 …”

Section: Potential Toxicity Of Chitosan Nanoparticlesmentioning

confidence: 99%

The Chemical Modification to Improve Solubility of Chitosan and Its Derivatives Application, Preparation Method, Toxicity as a Nanoparticles

Suryani,

Chaerunisaa,

Joni

et al. 2024

NSA

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Chitosan is a functional polymer in the pharmaceutical field, including for nanoparticle drug delivery systems. Chitosan-based nanoparticles are a promising carrier for a wide range of therapeutic agents and can be administered in various routes. Solubility is the main problem for its production and utilization in large-scale industries. Chitosan modifications have been employed to enhance its solubility, including chemical modification. Many reviews have reported the chemical modification but have not focused on the specific characteristics obtained. This review focused on the modification to improve chitosan solubility. Additionally, this review also focused on the application of chitosan derivatives in nanoparticle drug delivery systems since very few similar reviews have been reported. The specific method for chitosan derivative-based nanoparticles was also reported and the latest report of chitosan, chitosan derivative, and chitosan toxicity were also described.

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Preparation of chitosan based antibacterial agent CS-g-DMC and its long-effective antibacterial finishing for cotton fabric

Zhang,

He,

et al. 2023

Cellulose

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In this study, a chitosan-based high polymer antibacterial agent CS-g-DMC was synthesized through grafting copolymerization with an environmentally friendly initiator system of H 2 O 2 and ascorbic acid (Vc). The CS-g-DMC was used for the long-effective antibacterial nishing of cotton fabric. The SEM, EDS, FTIR, XPS, and XRD were conducted for the characterization of the fabric. Result showed CS-g-DMC combined with cellulose macro-molecule chemical bond, and had uniformly distributed on surface of cotton ber. After nishing, the cotton fabric had antibacterial rates against S. aureus and E. coli above 99.9% after 10 times of standard washing. The nished cotton fabric had signi cantly improved hydrophily, its contact angle decreased from 107° to 104°. Its breaking force signi cantly increased from 173.38 N to 219.33 N, and its breaking elongation and moisture transmission rate had not dropped obviously. In general, the cotton fabric nished by CS-g-DMC obtained long-effective antibacterial and increased mechanical properties, at meantime kept its comfortable capability to a great extent.

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High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles

Cited by 11 publications

References 10 publications

Benzothiazole Derivatives of Chitosan and Their Derived Nanoparticles: Synthesis and In Vitro and In Vivo Antibacterial Effects

Benzothiazole Derivatives of Chitosan and Their Derived Nanoparticles: Synthesis and In Vitro and In Vivo Antibacterial Effects

The Chemical Modification to Improve Solubility of Chitosan and Its Derivatives Application, Preparation Method, Toxicity as a Nanoparticles

Preparation of chitosan based antibacterial agent CS-g-DMC and its long-effective antibacterial finishing for cotton fabric

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