High ambient temperature alleviates the inflammatory response and growth depression in pigs challenged with Escherichia coli lipopolysaccharide

Campos, Paulo Henrique Reis Furtado; Merlot, Elodie; Damon, Marie; Noblet, Jean; Floc'H, Nathalie Le

doi:10.1016/j.tvjl.2014.04.001

Cited by 27 publications

(37 citation statements)

References 32 publications

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“…These equivocal findings may indicate that the induction of an acute inflammation state with a single injection of LPS is not the optimal method to demonstrate potential beneficial effects of dietary DHA on cytokine concentrations. The induction of a chronic inflammatory state by repeated LPS injections may be a more reliable method to test the effects of environmental changes, such as changes in diet or ambient temperature, e.g, on immune responses of pigs (67). This assumption is supported by a recent study that found that, compared with a single LPS injection, repeated injections of LPS resulted in higher brain proinflammatory cytokine responses in rats (68).…”

Section: Discussionmentioning

confidence: 95%

Maternal Fish Oil Supplementation Affects the Social Behavior, Brain Fatty Acid Profile, and Sickness Response of Piglets

Clouard

Souza

Gerrits

et al. 2015

The Journal of Nutrition

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Section: Discussionmentioning

confidence: 95%

Maternal Fish Oil Supplementation Affects the Social Behavior, Brain Fatty Acid Profile, and Sickness Response of Piglets

Clouard

Souza

Gerrits

et al. 2015

The Journal of Nutrition

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“…Several studies have shown that typical responses to LPS challenge in pigs are reduced feed intake, increase in body temperature (fever), strong increases in the concentrations of proinflammatory cytokines, APP and cortisol and reduction in the plasma concentration of insulin‐like growth factor (IGF)‐1. Reduced feed intake, increased energy requirement for the production of fever and hormonal changes shift the metabolism into a more catabolic state which results in reduced body weight gains and an impairment of the gain‐to‐feed ratio (Webel et al., ; Liu et al., ; Campos et al., ; Wyns et al., ). Increases of plasma non‐esterified fatty acids (NEFA) and urea concentrations after LPS challenge are indicative of an increased lipolysis in adipose tissue and an increased protein breakdown in muscle (Johnson, ).…”

Section: Consequences Of Inflammation On Performance Of Farm Animalsmentioning

confidence: 99%

Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals

Geßner

Ringseis

Eder

2016

Animal Physiology Nutrition

249

198

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Polyphenols are secondary plant metabolites which have been shown to exert antioxidative and antiinflamma tory effects in cell culture, rodent and human studies. Based on the fact that conditions of oxidative stress and inflammation are highly relevant in farm animals, polyphenols are considered as promising feed additives in the nutrition of farm animals. However, in contrast to many studies existing with model animals and humans, potential antioxidative and antiinflammatory effects of polyphenols have been less investigated in farm animals so far. This review aims to give an overview about potential antioxidative and antiinflammatory effects in farm animals. The first part of the review highlights the occurrence and the consequences of oxidative stress and inflammation on animal health and performance. The second part of the review deals with bioavailability and metabolism of polyphenols in farm animals. The third and main part of the review presents an overview of the findings from studies which investigated the effects of polyphenols of various plant sources in pigs, poultry and cattle, with particular consideration of effects on the antioxidant system and inflammation.

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“…However, recent studies of Campos et al (2014a,b) showed that acclimation to high ambient temperature might be beneficial in improving the capacity of growing pigs to limit the physiological and metabolic disturbances caused by an inflammatory challenge induced by repeated administrations of Escherichia coli LPS. In response to LPS and compared with pigs housed at 30 °C, pigs housed at 24 °C had higher concentrations of circulating pro-inflammatory cytokines associated with a greater magnitude of response of the HPA and HPT axes (Campos et al 2014a). In addition, LPS induces greater reduction in feed intake and growth depression in pigs housed at 24 °C than in those at 30 °C (Campos et al, 2014a,b).…”

Section: Impact On Animal Ability To Cope With a Sanitary Eventmentioning

confidence: 99%

Physiological responses of growing pigs to high ambient temperature and/or inflammatory challenges

et al. 2017

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-Global warming is one of the major environmental threats facing the world in the 21st century. This fact will have a significant impact on pig production due to its direct effects on welfare, health, and performance of pigs. Besides, the effects of high temperatures will presumably become more important over the next decades due to the development of pig production in developing countries mainly located in tropical and subtropical areas, where animals are often exposed to ambient temperatures above their thermal comfort zone. Furthermore, pigs reared in tropical areas are often confronted to sanitary challenges including poor hygiene conditions, lack of respect for sanitary rules, and pathogens. This results in the stimulation of the immune system and, as a consequence, in the production of pro-inflammatory cytokines and neuroendocrine adjustments that, in turn, usually have a negative impact on growth and feed efficiency. Although the effects of high ambient temperature and disease on pig physiology and performance have been well documented in literature, little is known about the associated effects of both factors. This understanding may contribute to a better quantification and comprehension of the physiological and metabolic disturbances occurring in practical conditions of pig production in tropical areas and, more generally, in many other geographic areas that will be influenced by the perspective of global warming. Therefore, the objective of this work is to provide an overview of recent research advances on the physiological responses of growing pigs during acclimation to high ambient temperature and on the potential effects of high ambient temperature on the ability of growing pigs to resist, cope with, or recover from an inflammatory challenge.

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High ambient temperature alleviates the inflammatory response and growth depression in pigs challenged with Escherichia coli lipopolysaccharide

Cited by 27 publications

References 32 publications

Maternal Fish Oil Supplementation Affects the Social Behavior, Brain Fatty Acid Profile, and Sickness Response of Piglets

Maternal Fish Oil Supplementation Affects the Social Behavior, Brain Fatty Acid Profile, and Sickness Response of Piglets

Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals

Physiological responses of growing pigs to high ambient temperature and/or inflammatory challenges

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