2012
DOI: 10.1371/journal.pone.0045228
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Abstract: BackgroundOral squamous cell carcinoma is an important cause of death and morbidity wordwide and effective prognostic markers are still to be discovered. HIF1α protein is associated with hypoxia response and neovascularization, essential conditions for solid tumors survival. The relationship between HIF1α expression, tumor progression and treatment response in head and neck cancer is still poorly understood.Patients and MethodsIn this study, we investigated HIF1α expression by immunohistochemistry in tissue mi… Show more

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Cited by 44 publications
(36 citation statements)
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References 47 publications
(32 reference statements)
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“…Disease-free survival is associated with high HIF-1 alpha levels. 19,20 However, in this study, Kaplan-Meier analysis showed that low oxygen tension is associated with better prognosis. 26 A multivariate analysis of overall survival showed a twofold increased risk of death in patients with regional nodal involvement.…”
Section: Discussioncontrasting
confidence: 52%
See 1 more Smart Citation
“…Disease-free survival is associated with high HIF-1 alpha levels. 19,20 However, in this study, Kaplan-Meier analysis showed that low oxygen tension is associated with better prognosis. 26 A multivariate analysis of overall survival showed a twofold increased risk of death in patients with regional nodal involvement.…”
Section: Discussioncontrasting
confidence: 52%
“…15,19 In addition, HIF-1 alpha expression has been reported in the early stages of OSCC and in proximal dysplastic epithelium. [19][20][21]24 In this study, HIF-1 alpha had different expression patterns in different OSCC subtypes and topographies. No other clinical data were correlated with HIF-1 status.…”
Section: Discussionmentioning
confidence: 99%
“…The signal intensity was scored as weak 1), moderate 2), and strong 3). Both scores were multiplied (dos Santos et al, 2012) and the resulting score was used to categorize DAP1 expression as negative (0), positive low (1-4), and positive high (≥4).…”
Section: Immunohistochemistrymentioning
confidence: 99%
“…Lack of CAIX and Glut-I expression along with high HIF-1α expression in squamous cell carcinoma indicates alternative mechanism for HIF-1α upregulation [26]. Furthermore, we have shown that the patients in good prognosis group had >50% HIF-1α positive tumor cells as reported for its strong expression in squamous cell carcinoma of oral cavity [27]. Diffuse HIF-1α expression based on tumor types and its nonhypoxic activation through various genetic alterations that might result in different outcomes [22,26] may also explain our observation.…”
Section: Discussionmentioning
confidence: 90%