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Cited by 2 publications
(2 citation statements)
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References 8 publications
(13 reference statements)
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“…In this study, CIRBP over-expression significantly decreased the level of HIF-1α and the ratio of apoptosis in the 1% hypoxia exposed SH-SY5Y cells, indicating that over-expressing CIRBP could suppress HIF-1α expression and alleviate the hypoxia induced apoptosis. Recently, Weibo Luo et al reported several HIF repressors under chronic hypoxia 53 . They found several genes, such as peroxiredoxin 2 (PRDX2) and PRDX4, suppressed the level of HIF-1α mRNA and its transcriptional activity.…”
Section: Discussionmentioning
confidence: 99%
“…In this study, CIRBP over-expression significantly decreased the level of HIF-1α and the ratio of apoptosis in the 1% hypoxia exposed SH-SY5Y cells, indicating that over-expressing CIRBP could suppress HIF-1α expression and alleviate the hypoxia induced apoptosis. Recently, Weibo Luo et al reported several HIF repressors under chronic hypoxia 53 . They found several genes, such as peroxiredoxin 2 (PRDX2) and PRDX4, suppressed the level of HIF-1α mRNA and its transcriptional activity.…”
Section: Discussionmentioning
confidence: 99%
“…In the present study, the overexpression of CIRP obviously decreased the HIF-1α level and the apoptotic rate of SH-SY5Y cells exposed to 1% O 2 , suggesting that the overexpression of CIRP can inhibit the HIF-1α expression and alleviate the hypoxia-induced apoptosis. Recently, Luo et al (18), reported several HIF inhibitors under chronic hypoxia, and found that several kinds of genes, such as peroxiredoxin 2 (PRDX2) and PRDX4, inhibit the HIF-1α mRNA level and transcriptional activity. Therefore, it is speculated that CIRP may repress HIF-1α during chronic hypobaric hypoxia-induced neuronal apoptosis.…”
Section: Discussionmentioning
confidence: 99%