volume 193, issue 10, P4924-4933 2014
DOI: 10.4049/jimmunol.1301829
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Dong Hoon Shin, Haiyue Lin, Haifeng Zheng, Kyung Su Kim, Jin Young Kim, Yang Sook Chun, Jong Wan Park, Joo Hyun Nam, Woo Kyung Kim, Yin Hua Zhang, Sung Joon Kim

Abstract: The general consensus is that immune cells are exposed to physiological hypoxia in vivo (PhyO2, 2-5% P(O2)). However, functional studies of B cells in hypoxic conditions are sparse. Recently, we reported the expression in mouse B cells of TASK-2, a member of pH-sensitive two-pore domain K(+) channels with background activity. In this study, we investigated the response of K(+) channels to sustained PhyO2 (sustained hypoxia [SH], 3% P(O2) for 24 h) in WEHI-231 mouse B cells. SH induced voltage-independent backg…

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