2017
DOI: 10.18632/aging.101267
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Abstract: In yeast, the broadly conserved acyl-CoA–binding protein (ACBP) is a negative regulator of stress resistance and longevity. Here, we have turned to the nematode C. elegans as a model organism in which to determine whether ACBPs play similar roles in multicellular organisms. We systematically inactivated each of the seven C. elegans ACBP paralogs and found that one of them, maa-1 (which encodes membrane-associated ACBP 1), is indeed involved in the regulation of longevity. In fact, loss of maa-1 promotes lifesp… Show more

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Cited by 14 publications
(11 citation statements)
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References 64 publications
(98 reference statements)
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“…Confirming our predictions, C. elegans carrying a loss of function allele of ahr-1 (Ahr in mice), display extended lifespan and increase motility and stress resistance (Eckers et al, 2016). Similarly in worms, knockdown of either acpb-1 or acbp-3 (Dbi in mice), extends lifespan (Shamalnasab et al, 2017). Among the interventions with a more positive correlation with short-lived mice and ageing, we found evidence of premature death in 6 cases, including Sirt7, Dicer1, Pdss2, Rb1 and Sgpl1 knockout mice (Frezzetti et al, 2011;Lin et al, 2011;Lyon and Hulse, 1971;Schmahl et al, 2007;Vakhrusheva et al, 2008).…”
Section: Identification Of Potential Novel Genetic Interventions Affesupporting
confidence: 74%
“…Confirming our predictions, C. elegans carrying a loss of function allele of ahr-1 (Ahr in mice), display extended lifespan and increase motility and stress resistance (Eckers et al, 2016). Similarly in worms, knockdown of either acpb-1 or acbp-3 (Dbi in mice), extends lifespan (Shamalnasab et al, 2017). Among the interventions with a more positive correlation with short-lived mice and ageing, we found evidence of premature death in 6 cases, including Sirt7, Dicer1, Pdss2, Rb1 and Sgpl1 knockout mice (Frezzetti et al, 2011;Lin et al, 2011;Lyon and Hulse, 1971;Schmahl et al, 2007;Vakhrusheva et al, 2008).…”
Section: Identification Of Potential Novel Genetic Interventions Affesupporting
confidence: 74%
“…The ne219 allele was used as the RNAi deficient genetic background for tissue specific rescue of RNAi function (Qadota et al 2007). This technique of tissue-specific RNAi has been cited in over 70 publications, including these recent studies (Shamalnasab et al 2017;Liu et al 2017;Jeong et al 2017;Chun et al 2017;Han et al 2017). Our findings indicate that the results of these studies must be carefully interpreted, and future studies of gene knockdowns in specific tissues should not use the rde-1(ne219) background, because this strain is not completely RNAi deficient.…”
Section: Discussionmentioning
confidence: 93%
“…HIF-1 is required for the anti-ageing response induced by MAA-1 deficiency. This response relies on the activation of molecular chaperones known to contribute to maintenance of the proteome [ 102 ]. The discrepancy between studies could be explained through temperature.…”
Section: Lifespan Effects Of Mtor Through Regulation Of Gene Transmentioning
confidence: 99%