Hierarchical Superstructure of Plant Polyphenol and Arginine Surfactant for Long‐Lasting and Target‐Selective Antimicrobial Application

Abstract

Antimicrobial agents are massively used to disinfect the pathogen contaminated surfaces since the Corona Virus Disease 2019 (COVID‐19) outbreak. However, their defects of poor durability, strong irritation, and high environmental accumulation are exposed. Herein, a convenient strategy is developed to fabricate long‐lasting and target‐selective antimicrobial agent with the special hierarchical structure through bottom–up assembly of natural gallic acid with arginine surfactant. The assembly starts from rodlike micelles, further stacking into hexagonal columns and finally interpenetrating into spherical assemblies, which avoid explosive release of antimicrobial units. The assemblies show anti‐water washing and high adhesion on various surfaces; and thus, possess highly efficient and broad‐spectrum antimicrobial activities even after using up to eleven cycles. Both in vitro and in vivo experiments prove that the assemblies are highly selective in killing pathogens without generating toxicity. The excellent antimicrobial virtues well satisfy the increasing anti‐infection demands and the hierarchical assembly exhibits great potential as a clinical candidate.

Non-destructive real-time monitoring and investigation of the self-assembly process using fluorescent probes

“…When the surface adsorption reaches the critical micelle concentration, there will be no more enrichment of surfactant molecules on the surface. 79,80 However, the interaction between hydrophobic groups still allows the molecules to escape from the water environment, and the surfactant molecules will self-aggregate in the solution. In this process, the hydrophobic groups aggregate as the core and the hydrophilic groups contact with water to form the shell.…”

Retrospect and Prospect of Long-lasting Antibacterial Materials★

“…例如, 将抗菌剂通过物理作用 (超声或者电沉积)直接涂覆到靶体表面; 或通过化学反 应将抗菌材料接枝到靶体表面. 近年来, 非共价组装以 及结合的方式已经开始被利用构筑长效抗菌材料并且 结合到靶体上, 其显示出简便易行和基底广泛适用性的 独特优势 [14][15] . 本文主要从长效抗菌材料在涂层、棉纤维和织物、 伤口愈合敷料、体内植入物、水处理过滤膜以及其它方 面的应用介绍了其发展现状, 也对长效抗菌材料的未来 发展方向进行了展望.…”

“…图 1 没食子酸与阳离子季铵盐表面活性剂非共价组装构筑具有基底 粘附性的长效抗菌疏水球的示意图 [14] Figure 1 Schematic illustration for construction of substrate-adhesive hydrophobic spheres with long-lasting antibacterial activity based on non-covalent assembly of gallic acid and cationic quaternary ammonium surfactants [14] 最近, 我们又利用精氨酸表面活性剂与没食子酸同 样构筑了长效抗菌的疏水球 [15] 图 2 没食子酸与精氨酸表面活性剂非共价组装制备具有持久和病原 菌靶向性抗菌的多级组装体示意图 [15] Figure 2 Schematic diagram of hierarchical aggregates with long-lasting and target-selective antibacterial features fabricated through bottom-up assembly of gallic acid with arginine surfactant [15] 3 总结与展望…”

Unraveling the Intricate Interaction: Bonding Mechanism between Tannic Acid and Wood Fibers

“…Tannic acid (TA) is a polyphenolic compound widely distributed in plants, which can be extracted economically from natural sources like oak bark, chestnuts, and hemlock . With excellent biocompatibility, TA serves as a crucial raw material with diverse applications, from tanning agents to coatings and adhesives, as well as in the medical and food industries . The molecular structure of TA comprises 10 gallic acids linked to a central glucose molecule by ester bonds, making it possess antioxidant, anti-inflammatory, broad-spectrum antibacterial, and antitumor properties .…”