Hierarchical multifunctional graphene oxide cancer nanotheranostics agent for synchronous switchable fluorescence imaging and chemical therapy

Esmaeili, Yasaman; Zarrabi, Ali; Mirahmadi-Zare, Seyede Zohreh; Bidram, Elham

doi:10.1007/s00604-020-04490-6

Cited by 21 publications

(8 citation statements)

References 63 publications

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“…The chemical composition of GO-PEG-antibiotics was also studied using EDX analysis coupled with FE-SEM. The zeta potential of the compounds was evaluated by Horiba SZ-100 particle size analyzer (Horiba SZ-100; Kyoto, Japan) [ 34 , 35 , 36 , 37 ].…”

Section: Methodsmentioning

confidence: 99%

Penicillin and Oxacillin Loaded on PEGylated-Graphene Oxide to Enhance the Activity of the Antibiotics against Methicillin-Resistant Staphylococcus aureus

et al. 2022

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Infectious diseases are known as the second biggest cause of death worldwide, due to the development of antibiotic resistance. To overcome this problem, nanotechnology offers some promising approaches, such as drug delivery systems that can enhance drug efficiency. Herein, a Graphene Oxide-polyethylene glycol (GO-PEG) nano-platform was synthesized and penicillin and oxacillin, two antibiotics that are ineffective against Methicillin-resistant S. aureus (MRSA), were loaded on it to improve their effectiveness. The nanocomposites were characterized using FTIR, XRD, UV–Vis, FE-SEM/EDX, and Zeta potential analyses, followed by an evaluation of their antibacterial activity toward MRSA. Based on the results, drug loaded GO-PEG nanocomposites with loading efficiencies of 81% and 92% for penicillin and oxacillin, respectively, were successfully synthesized. They showed a controlled release within six days. The zeta potential of GO-PEG-oxacillin and penicillin was −13 mV and −11 mV, respectively. The composites showed much more activity against MRSA (80–85% inhibition) in comparison to GO-PEG (almost 0% inhibition) and pure antibiotics (40–45% inhibition). SEM images of MRSA treated with GO-PEG-antibiotics showed a deformation in the structure of bacterial cells, which led to the collapse of their intracellular components. These results demonstrate the effectiveness of utilizing the GO-based nanoplatforms in enhancing the antibacterial activity of the antibiotics.

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Section: Methodsmentioning

confidence: 99%

Penicillin and Oxacillin Loaded on PEGylated-Graphene Oxide to Enhance the Activity of the Antibiotics against Methicillin-Resistant Staphylococcus aureus

et al. 2022

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“…Bioactive nanomaterials promise to significantly advance several fields in nanomedicine, [181,182] bioapplications, [183,184] and bioactive nanomaterials. [185][186][187] In addition to reactions where natural materials are broken down to atoms or small fragments and then rebuild into carbonaceous materials with a completely different structure, e.g., graphene, plasma environment can be sufficiently gentle to sustain the fabrication of polymers and polymer-like structures where the chemical structure and hence inherent biochemical activity of the precursor is preserved.…”

Section: Plasma-synthesized Bioactive Polymers and Coatings From Natu...mentioning

confidence: 99%

Functional Nanomaterials from Waste and Low‐Value Natural Products: A Technological Approach Level

Levchenko

Mandhakini

Prasad

et al. 2022

Adv Materials Technologies

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Low‐ and negative‐value (waste) products represent a valuable resource. Its use as a source for the fabrication of high value materials represents a lucrative pathway to increasing sustainability and decreasing the economic cost of various industries. Thermochemical methods for the valorization of biowaste and low‐value natural products are simple and cheap yet sufficiently efficient to deliver significant economic benefits. Plasma‐based methods represent another family of technologies for waste‐to‐value conversion. The nanostructure nucleation and growth in plasmas involve a complex set of physical and chemical processes that occur in bulk plasma and on surfaces. The choice between these two types of technology assumes a complex optimization that takes into account several factors including the cost of precursors; initial outlay and operating cost of equipment; the cost of labor; the cost of production engineering including the research and development efforts for designing the industrial technology, which is typically higher for the plasma‐based systems, and so on. In this article a technology level comparison of thermochemical and plasma‐based techniques for the valorization of raw and waste biomass, where the intent is to use the resulting products for environmental remediation, energy storage, optoelectronics, and biomedical applications, is presented.

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“…Hybrid nanosheets fabricated by immobilization of Au nanorods onto the surface of PEGylated GO via polydopamine and showing an 86.16% DOX-loading capacity and a very low cytotoxicity to MCF-7 cells exhibited a pH/NIR-stimuli-responsive drug release, suggesting that they can be utilized as a superb platform for remotely triggered drug delivery [ 231 ]. A multifunctional cancer nanotheranostics system for non-invasive imaging, and targeted chemotherapy and tracing particular biomarkers based on PEGylated GO-AuNPs and specified with aptamer toward the mucin-1 (MUC-1)-positive tumor cells acting as an “on/off” fluorescence biosensor loaded with DOX was designed by Esmaeili et al [ 232 ] A nanocomposite consisting of SiO 2 -based mesoporous Ti nanocarriers with photoactivable GO modified with a stealth polymer for delivery of imatinib, which can be used for NIR-triggered drug delivery and enhanced chemo-photothermal therapy was prepared by Gautam et al [ 233 ] Drug release from this carrier achieved ca. 60% under light condition at pH 5 and the formulation efficiently converted NIR light into thermal energy (43.2 °C), which resulted in ROS generation.…”

Section: Graphene Oxidementioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Jampílek

Kráľová

2021

Materials

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Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

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Hierarchical multifunctional graphene oxide cancer nanotheranostics agent for synchronous switchable fluorescence imaging and chemical therapy

Cited by 21 publications

References 63 publications

Penicillin and Oxacillin Loaded on PEGylated-Graphene Oxide to Enhance the Activity of the Antibiotics against Methicillin-Resistant Staphylococcus aureus

Penicillin and Oxacillin Loaded on PEGylated-Graphene Oxide to Enhance the Activity of the Antibiotics against Methicillin-Resistant Staphylococcus aureus

Functional Nanomaterials from Waste and Low‐Value Natural Products: A Technological Approach Level

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

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