Hierarchical linear modeling (HLM) of longitudinal brain structural and cognitive changes in alcohol-dependent individuals during sobriety

Yeh, Ping‐Hong; Gaździński, Stefan; Durazzo, Timothy C.; Sjöstrand, Karl; Meyerhoff, Dieter J.

doi:10.1016/j.drugalcdep.2007.05.027

Cited by 51 publications

(39 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While alcoholism is a chronic, long-term disease associated with severely compromised CV health, the finding of recovery in ANS function with 4 months of abstinence adds to other data showing recovery in sleep EEG activity (Colrain, Padilla, & Baker, 2012), brain structure (Cardenas, Studholme, Gazdzinski, Durazzo, & Meyerhoff, 2007), and aspects of alcoholism-related cognitive and motor decline (Fein & McGillivray, 2007; Yeh, Gazdzinski, Durazzo, Sjöstrand, & Meyerhoff, 2007), although recovery in these domains shows substantial individual variability.…”

Section: Discussionmentioning

confidence: 63%

Cardiac autonomic function during sleep: Effects of alcohol dependence and evidence of partial recovery with abstinence

Zambotti

Willoughby

Baker

et al. 2015

Alcohol

View full text Add to dashboard Cite

Chronic alcoholism is associated with the development of cardiac and peripheral autonomic nervous system (ANS) pathology. The aim of the present study was to evaluate the extent to which recovery in ANS function could be demonstrated over the first 4 months of abstinence. Fifteen alcoholics (7 women) were studied on three occasions: within a month of detoxification, at approximately 2 months post-detox, and at 4 months post-detox. Thirteen control subjects (6 women) were also studied on three occasions with inter-study intervals matching those of the alcoholics. Six alcoholics relapsed, 48.7 ± 27.9 days following the initial PSG session. ANS function was assessed in the first part of stable non-rapid eye movement sleep. Frequency-domain power spectral analysis of heart rate variability (HRV) produced variables including: heart rate (HR), total power (TP; an index representing total HR variability), High Frequency power (HFa; an index reflecting cardiac vagal modulation), HF proportion of total power (HFprop sympathovagal balance), and HF peak frequency (HFpf; an index reflecting respiration rate). Overall, high total and high frequency variability and low sympathovagal balance and myocardial contractility are considered as desired conditions to promote cardiovascular health. At initial assessment, alcoholics had a higher HR (p < 0.001) and respiratory rate (p < 0.01), and lower vagal activity (HFa; p < 0.01) than controls. Alcoholics showed evidence of recovery in HR (p = 0.039) and HFa (p = 0.031) with 4 months of abstinence. Alcoholics with higher TP at the initial visit showed a greater improvement in TP from the initial to the 4-month follow-up session (r = 0.75, p < 0.05). Alcoholics showed substantial recovery in HR and vagal modulation of HRV with 4 months of abstinence, with evidence that the extent of recovery in HRV may be partially determined by the extent of alcohol dependence-related insult to the cardiac ANS system. These data support other studies showing recovery in a number of ANS, central nervous system, and behavioral domains with abstinence, even in those with long-term dependence.

show abstract

Section: Discussionmentioning

confidence: 63%

Cardiac autonomic function during sleep: Effects of alcohol dependence and evidence of partial recovery with abstinence

Zambotti

Willoughby

Baker

et al. 2015

Alcohol

View full text Add to dashboard Cite

show abstract

“…In addition to ventricular shrinkage, she exhibited resolution of radiological evidence for central pontine myelinolysis, which if left untreated, can be fatal (Lampl & Yazdi, 2002;). In addition to single case studies, an ever-increasing number of longitudinal MRI studies on groups of alcoholics report significant changes in regional brain volumes (e.g., Cardenas, Studholme, Gazdzinski, Durazzo, & Meyerhoff, 2007;Rohlfing, Sullivan, & Pfefferbaum, 2006;Shear, Jernigan, & Butters, 1994;Wang et al, 2016;Yeh, Gazdzinski, Durazzo, Sjostrand, & Meyerhoff, 2007). An early study imaged alcoholics approximately a week after detoxification and again approximately 3 weeks later, at the end of a 28-day VA inpatient treatment regime with enforced abstinence.…”

Section: Learn That Sustained Sobriety Can Results In Improvement In Bmentioning

confidence: 99%

Contributions to Understanding the Neuropsychology of Alcoholism: An INS Legacy

Sullivan

2017

J Int Neuropsychol Soc

View full text Add to dashboard Cite

Alcohol use disorder (AUD) has been a major cause of family, social, and personal strife for centuries, with current prevalence estimates of 14% for 12-month and 29% lifetime AUD. Neuropsychological testing of selective cognitive, sensory, and motor functions complemented with in vivo brain imaging has enabled tracking the consequences of AUD, which follows a dynamic course of development, maintenance, and recovery or relapse. Controlled studies of alcoholism reviewed herein provide evidence for disruption of selective functions involving executive, visuospatial, mnemonic, emotional, and attentional processes, response inhibition, prosody, and postural stability and brain systems supporting these functions. On a hopeful front, longitudinal study provides convincing evidence for improvement in brain structure and function following sustained sobriety. These discoveries have a strong legacy in the International Neuropsychological Society (INS), starting from its early days when assumptions regarding which brain regions were disrupted relied solely on patterns of functional sparing and impairment deduced from testing. This review is based on the symposium presentation delivered at the 2017 annual North American meeting of the INS in celebration of the 50th anniversary since its institution in 1967. In the spirit of the meeting's theme, "Binding the Past and Present," the lecture and this review recognized the past by focusing on early, rigorous neuropsychological studies of alcoholism and their influence on research currently conducted using imaging methods enabling hypothesis testing of brain substrates of observed functional deficits. (JINS, 2017, 23, 843-859)

show abstract

“…In other words, this approach is analogous to an experimental design manipulation (which is, however, precluded by contingency of reward and effort) in using information from low-reward, but high-effort trials and high-reward, but low-effort trials, to improve estimation of coefficients for all trials in all participants. Consequently, multilevel analysis (as implemented in HLM; Raudenbush and Bryk, 2002;Raudenbush et al, 2004) has been used several times before using both structural (Yeh et al, 2007) and functional MRI data (Schacht et al, 2011(Schacht et al, , 2013 due to its advantageous computational properties.…”

Section: Rationale Of Multilevel Modeling Approachmentioning

confidence: 99%

Balancing reward and work: Anticipatory brain activation in NAcc and VTA predict effort differentially

et al. 2014

View full text Add to dashboard Cite

Hierarchical linear modeling (HLM) of longitudinal brain structural and cognitive changes in alcohol-dependent individuals during sobriety

Cited by 51 publications

References 41 publications

Cardiac autonomic function during sleep: Effects of alcohol dependence and evidence of partial recovery with abstinence

Cardiac autonomic function during sleep: Effects of alcohol dependence and evidence of partial recovery with abstinence

Contributions to Understanding the Neuropsychology of Alcoholism: An INS Legacy

Balancing reward and work: Anticipatory brain activation in NAcc and VTA predict effort differentially

Contact Info

Product

Resources

About