Hidrotic ectodermal dysplasia with diffuse eccrine syringofibroadenomatosis

Eccrine syringofibroadenomatosis associated with hidrotic ectodermal dysplasia

“…2,4,6,7,17,26,27,31 Ten of these patients had HED. 2,4,26,27,31 This disorder is an autosomal dominant syndrome whose genetic aberration has recently been localized to chromosome 13q. 32 In HED, ectodermal tissues such as hair, teeth and nails are poorly formed, sparse or absent.…”

Eccrine Syringofibroadenoma: Report of a Case and Analysis of Cytokeratin Expression

“…There is a trend that a single lesion is diagnosed as an adenoma [9, 10], and multiple lesions in a symmetrical or linear distribution are diagnosed as nevoid lesions [12, 13]. Multiple lesions occasionally develop in a patient with hydrotic ectodermal dysplasia, and these are considered as a variant of nevoid lesion [14, 15, 16]. In addition, Nomura et al [17] proposed the term ‘eccrine syringofibroadenomatous hyperplasia’ showing a patient with bullous pemphigoid who suffered from multiple erythematous lesions on the palms and soles.…”

Eccrine syringofibroadenoma in a patient with a burn scar ulcer

“…2±5 Cases with multiple papular lesions are also described as eccrine syringofibroadenomatosis. 6 Histologically, it is a distinct tumour composed of a proliferation of anastomosing strands, cords and columns of monomorphous epithelial cells harbouring eccrine duct formations, embedded in a fibrovascular stroma. Owing to clinical polymorphism, it is still unclear whether ESFA is a neoplasm, a hamartoma or reactive eccrine hyperplasia.…”