Hidradenitis supurativa prepuberal: presentación de 2 casos clínicos

Silva-Feistner, Marcos; Salomone, Claudia; Silva, Sérgio; Vial-Letelier, Verónica

doi:10.1016/j.rchipe.2015.10.001

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…3 On the other hand, it is known that PDT acts selectively on the hypertrophic follicular epithelium that produces follicular plugging, without affecting healthy cells. 29 As of January 2016, 9 articles endorse PDT for HS, [20][21][22][23][25][26][27]31,33 whereas 4 articles describe failure or no response. 24,29,34,35 Only in one of the four articles that report failure, blue light instead of red light was used.…”

Section: Resultsmentioning

confidence: 99%

“…35 In all of them, the PS used was ALA, with different incubation times. Of the 9 articles favouring PDT, ALA was used in 6 of them, 23,[25][26][27]31,33 MAL in 2 of them 20,21 and MB in only 1. 22 The results of these articles are summarized in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…Methylene blue (MB) has also been used as a photosensitizer with intense pulsed light (IPL) with a 630 nm filter or 635 nm-light emitting diode lamps as photo-activators. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Encouraged by the preliminary results of PDT in HS, we have performed this therapeutic option in seven of our HS patients with variable success, and we herein report our results.…”

Section: Introductionmentioning

confidence: 99%

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Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature

Agut-Busquet

Romaní

Gilaberte

et al. 2016

Photochem Photobiol Sci

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Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence of 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body. It is believed that its pathogenesis involves an aberrant, genetically-determined activation of innate immunity against the bacterial commensal flora of intertriginous areas. It has been found that the formation of antibiotic-resistant bacterial biofilms is a common finding in hidradenitis lesions. Photodynamic therapy with different compounds and light sources has demonstrated its efficacy in a number of infectious diseases such as nail mycosis and chronic periodontitis. We retrospectively report our experience in the treatment of hidradenitis with photodynamic therapy using intralesional methylene blue and a 635 nm light-emitting diode lamp in 7 patients. Two patients received one session whereas 5 patients received two sessions. At one month follow-up good response was achieved in 6 patients. After 6 months, 5 patients (71%) maintained remission of the disease in the treated area. In view of the results and literature review, we regard methylene blue as an ideal photosensitizer for photodynamic therapy in this disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature

Agut-Busquet

Romaní

Gilaberte

et al. 2016

Photochem Photobiol Sci

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“…Aunque, en general, se ha descrito que la hidradenitis es una enfermedad pospubertad, también se ha reportado en niños (13)(14)(15)(16) . Nosotros encontramos una paciente de 12 años.…”

Section: Discussionunclassified

Hidradenitis supurativa. Descripción de los hallazgos ecográficos en un centro de referencia en Bogotá, Colombia

Díaz¹

2020

rev. asoc. colomb. dermatol. cir. dematol.

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Introducción: el ultrasonido de alta resolucion de tejidos blandos es una herramienta util para la caracterización de los hallazgos de hidradenitis supurativa (HS). Se presenta una serie de 27 pacientes con diagnostico clinico de HS, en quienes se practico ultrasonido de alta resolucion. Objetivos: describir los hallazgos ecograficos mas frecuentes en pacientes con HS. Establecer el estadiaje de Hurley ecografico. Describir los hallazgos ecograficos no evidentes clinicamente de la enfermedad. Identificar la actividad inflamatoria de la HS mediante el uso del analisis Doppler. Métodos: es un estudio retrospectivo, descriptivo. Se realizo ecografia de alta resolucion por parte de una radióloga con experiencia en ecografia dermatologica. Se empleo un equipo TOSHIBA XARIO 200 con transductor lineal de alta resolucion de 18 a 22 MHz. El registro se llevo a en un reporte unificado creado para el estudio tomando como base el reporte sugerido por el grupo DERMUS, del cual la investigadora forma parte y ayudo a desarrollar. Para el analisis estadistico se emplearon medidas de tendencia central, descripcion de frecuencias y cruce de variables. Resultados: la edad promedio fue de 44,7 anos. El 74,1% de los pacientes fue mujeres. La zona corporal mas afectada fue las axilas (55,5%). El hallazgo ecografico mas comun fue la presencia de fistulas. Se encontro aumento de la vascularizacion al analisis Doppler en el 80% de las fistulas, lo que indica actividad inflamatoria. El estadio I de Hurley se encontro en el 37,04%. Conclusión: la ecografia evidencio fistulas ocultas en el 29,6% de los pacientes, que llevaron a modificar el estadiaje clinico de la enfermedad. La ecografia es un metodo importante para el correcto abordaje de los pacientes con HS.

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“…HS disease has been noted to be steadily rising over the last 40 years in the US, ostensibly due to an increase in obesity [ 9 ]. Recent studies increasingly indicate a strong association between hidradenitis and obesity [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Enhanced levels of insulin have been suggested as the linkage due to enhanced bioavailable androgen production [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report

Khandalavala¹

2017

Case Rep Dermatol

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Hidradenitis suppurativa (HS) is a challenging skin disease with limited therapeutic options. Obesity and metabolic syndrome are being increasingly implicated and associated with younger ages and greater metabolic severity. A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. A combination of metformin, liraglutide, levonorgestrel-ethinyl estradiol, dapsone, and finasteride was initiated. Acute antibiotic use for recurrences and flares could be slowly discontinued. Over the course of 3 years on this regimen, the liver enzymes normalized in 1 year, followed in2 years by complete resolution of the majority of the hematological and metabolic abnormalities. The sedimentation rate reduced from over 120 to 34 mm/h. She required 1 surgical intervention for perianal disease after 9 months on the regimen. Flares greatly diminished in intensity and duration, with none in the past 6 months. Right axillary lesions have completely healed with residual disease greatly reduced. Chiefly abdominal lesions are persistent. She was able to complete high school from home, start a job, and resume a normal life. Initial weight loss of 40 pounds was not maintained. The current regimen is being well tolerated and continued.

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Hidradenitis supurativa prepuberal: presentación de 2 casos clínicos

Abstract: The etiology of HS is unclear. Usually the presentation at early age is associated with a family history and more extensive compromise in the future. Treatment is difficult and depends on each case and severity.

Cited by 6 publications

References 20 publications

Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature

Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature

Hidradenitis supurativa. Descripción de los hallazgos ecográficos en un centro de referencia en Bogotá, Colombia

A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report

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