Hibernoma: Distinctive light and electron microscopic features and relationship to brown adipose tissue

Gaffney, Eoin F.; Hargreaves, Hilary K.; Semple, Eugene; Vellios, Frank

doi:10.1016/s0046-8177(83)80139-7

Cited by 88 publications

(47 citation statements)

References 43 publications

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“…5,8 Ultrastructural studies demonstrate round to tubular mitochondria in hibernoma cells, and these are more abundant, pleomorphic, and larger in brown fat than white fat. 4,9,10 Cytogenetic aberrations seen in hibernomas include structural rearrangements of 11q13 and 11q21; however, these aberrations are also shared by other lipomatous neoplasms such as lipoma and myxoid liposarcomas and are not unique to hibernomas. Studies have found structural aberrations of 11q13 to be associated with deletions of multiple endocrine neoplasia 1 (MEN1) region in 11q13.1.…”

Section: Clinical Featuresmentioning

confidence: 99%

Mammary Hibernoma: A Rare Entity

Riley

Karamchandani²

2014

Archives of Pathology &Amp; Laboratory Medicine

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Hibernoma arising in the breast is rare and may present as an asymptomatic mass or may be detected by screening mammography. Four histologic types have been identified: typical, myxoid variant, spindle cell variant, and the lipoma-like variant. The most common “typical variant” is composed of pale to eosinophilic multivacuolated cells with interspersed univacuolar cells. Hibernomas are universally benign and are not known to recur or have an aggressive behavior, even in incompletely excised lesions. Hence, their clinical importance lies in distinguishing them from other benign and malignant breast neoplasms as well as inflammatory conditions that come into the histologic or radiologic differential. This review discusses the clinical features, radiologic and histopathologic characteristics, ancillary studies, suggested pathogenesis, differential diagnosis, and treatment of and prognosis for these uncommon lesions.

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Section: Clinical Featuresmentioning

confidence: 99%

Mammary Hibernoma: A Rare Entity

Riley

Karamchandani²

2014

Archives of Pathology &Amp; Laboratory Medicine

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“…20 However, unlike the tumor cells of this particular case, the tumor cells of oncocytomas do not contain lipid droplets in the cytoplasm. Hibernomas are benign tumors arising from brown fat, 9 the immature adipose tissue commonly seen in fetuses. Ultrastructural feature of hibernomas is that mitochondria are not only densely packed within the cytoplasm but also somewhat pleomorphic in contour with dense matrix as well as narrowly spaced cristae, 9 which were not observed in this Japanese macaque.…”

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confidence: 99%

Round Cell Variant of Myxoid Liposarcoma in a Japanese Macaque (Macaca fuscata)

et al. 2007

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Abstract.A 5-year-old, female, Japanese Macaque (Macaca fuscata) was diagnosed with round cell variant of myxoid liposarcoma. At necropsy, multifocal to coalescing, reddish tan to white nodules, ranging from 0.5 to 1 cm in diameter, were noted throughout the omentum and retroperitoneum. Similar neoplastic nodules were also present in diaphragm, abdominal wall, and on hepatic capsule. Microscopically, neoplastic masses consisted of round to polyhedral cells, which had round, often eccentric nuclei and abundant eosinophilic granular and microvacuolated cytoplasm; Oil red O staining demonstrated large numbers of lipid droplets in the cytoplasm. Ultrastructurally, the cytoplasm of the tumor cells was packed with occasional lipid vacuoles and numerous enlarged mitochondria. Immunohistochemistry revealed tumor cells were positive for vimentin, while negative to cytokeratin, actin, and Factor VIII-related antigen. To the authors' knowledge, this is the first report of round-cell variant of myxoid liposarcoma in nonhuman primate.

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“…6 The ultrastructural features of this hibernoma are very similar to those described by Levine 7 and others. 5,8 The overall features have a close resemblance to those of brown fat. The mitochondria in the white adipose tissue are small and infrequent, whereas those in brown adipose tissue are large, numerous and lieadjacent to the fat vacuoles.…”

Section: Figure 3b Scattered Granular Eosinophilic Cells Are Also Idmentioning

confidence: 89%

“…Brown adipose tissue was first recognizable in the lateral cervical tissue of fetuses of 21 weeks' gestational age and was also evidenced in the mediastinum and around the kidneys of fetuses older than 24 weeks' gestational age. 5 It is distributed mainly in the interscapular area, neck, mediastinum and retroperitoneum. Usually, the amount of brown adipose tissue decreases after birth, but small quantities persist in adults.…”

Section: Discussionmentioning

confidence: 99%

Hibernoma: A New Case in the Submandibular Region

et al. 1996

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The hibernoma is an uncommon, benign soft tissue tumor arising from vestigial remnants of so-called brown fat. It most commonly occurs in the interscapular regions, but there are also a number of cases originating in sites normally devoid of brown fat. Most of these tumors are subcutaneous; nevertheless, deep-seated hibernomas have been reported in intrathoracic sites. A hibernoma in the head and neck region is very rare, and few cases in this location have been reported. [1][2][3][4] We report a case of hibernoma in the submandibular space with immunohistochemical and ultrastructural study. Case ReportA 55-year-old male was admitted with a six-month history of a slow-growing, painless mass in the submandibular area. There was no significant past medical or surgical history and a thorough examination of the head and neck revealed no other abnormalities. All laboratory studies were normal. With the clinical diagnosis of primitive submandibular gland tumor, the patient was scheduled for surgery. The surgical specimen consisted of a yellow-brown, well demarcated and encapsulated tumor measuring 3.5 x 2.5 cm, joined to the submandibular gland (Figure 1). Microscopically, the neoplasm displayed a distinct lobular pattern and four types of cells could be recognized: most cells contained numerous small round lipid vacuoles that did not indent the regular and spherical nucleus (cells with moruloid or mulberry appearance). The second type of cells were larger and showed an eccentrically displaced nucleus, indistinguishable from a normal mature fat cell (Figure 2). The third type of cells contained lipid vacuoles which indented the central nucleus, then became indistinguishable from a multivacuolated lipoblast ( Figure 3A), and the fourth type consisted of isolated polygonal cells with eosinophilic granular cytoplasm and small, regular spherical nucleus ( Figure 3B). Mitoses and pleomorphism were absent. A rich vascular network was found. The histological features were considered to be those of a hibernoma. Ultrastructurally, the cells were polygonal with multiple well-defined droplets of lipid of variable size and large round to oval mitochondria which occupied much of the cytoplasm remaining between the fat droplets ( Figure 4A). These mitochondria were tightly packed, with highly organized and parallel straight transverse cristae ( Figure 4B). The mitochondrial matrix was of medium to high density and showed large and abundant dense granules. The endoplasmic reticulum was very scarce and the Golgi apparatus inconspicuous. The nuclei were round and contained uniformly distributed chromatin condensed under nuclear membrane. In some cells, multiple intracytoplasmic lipid droplets caused scalloping of the centrally situated nucleus. Hibernoma cells were surrounded by a well-defined basal lamina. Immunohistochemically, tumor cells showed diffuse vimentin reactivity. Staining for S-100 protein was focally positive. Hibernoma cells did not react with antibodies directed against cytokeratin, CD68, epithelial membrane antigen (...

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Hibernoma: Distinctive light and electron microscopic features and relationship to brown adipose tissue

Cited by 88 publications

References 43 publications

Mammary Hibernoma: A Rare Entity

Mammary Hibernoma: A Rare Entity

Round Cell Variant of Myxoid Liposarcoma in a Japanese Macaque (Macaca fuscata)

Hibernoma: A New Case in the Submandibular Region

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