2016
DOI: 10.1007/s00464-016-4858-1
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Abstract: Our data indicate that the composition of POL for patients with GERD and HH includes less total, type-I, and type-III collagens than that of the POL of cadavers without HH. The quality of the POL may be an etiological factor in the development of HH.

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Cited by 25 publications
(13 citation statements)
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“…Patients may have symptoms such as acid reflux and heartburn. In severe cases, complications such as esophageal stenosis, bleeding, and cancer may occur (7). According to a systematic review in 2005, the prevalence of GERD is 10-20% in western countries and less than 5% in Asian countries.…”
Section: Introductionmentioning
confidence: 99%
“…Patients may have symptoms such as acid reflux and heartburn. In severe cases, complications such as esophageal stenosis, bleeding, and cancer may occur (7). According to a systematic review in 2005, the prevalence of GERD is 10-20% in western countries and less than 5% in Asian countries.…”
Section: Introductionmentioning
confidence: 99%
“…22 In a study from 2016, biopsies from the PEL of 29 patients undergoing repair of a hiatal hernia were compared to samples obtained from 32 cadavers without a hiatal hernia. 23 Total collagen in the PEL was 60% lower in patients with a hiatal hernia compared to controls ( P < .01). While a decreased ratio of Type I to Type 3 collagen has been observed in patients with incisional and inguinal hernias, it has yet to be documented in hiatal hernias.…”
Section: Contributors To the Development Of Hiatal Herniamentioning
confidence: 88%
“…Therefore, we decided to determine and compare the level of collagen types І and ІІІ in the POL in patients with large HH and cadavers without HH. In order to obtain reliable results in determining the level of collagens, we used the technique described by von Diemen et al 9 in one of the more recent studies. Our findings have shown that the level of collagen type І and ІІІ in POL in patients with large HH is reduced.…”
Section: Discussionmentioning
confidence: 99%