Hexose Monophosphate Shunt Enzymes in Lung Tumors from Normal and Glucose-6-Phosphate-Dehydrogenase-Deficient Subjects

Dessı̀, Sandra; Batetta, Barbara; Cherchi, R.; Onnis, R.; Pisano, Maria Paola; Pani, P.

doi:10.1159/000226624

Cited by 27 publications

(17 citation statements)

References 14 publications

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“…As we mentioned earlier, large numbers of studies revealed elevated G6PD activities were found in various cancers [8][9][10][11][12][13][14][15][16][17], overexpression of G6PD can promote tumorigenesis [5] and silencing G6PD expression by siRNA decreased tumor-cell proliferation and enhanced apoptosis [7]. Consistent with this, Wang-Ni Tian et al found that G6PD activity correlate with cell proliferation and cells overexpressing G6PD have a higher proliferation rate than that expressing only endogenous G6PD [26].…”

Section: Discussionmentioning

confidence: 65%

“…Li et al demonstrated that silencing G6PD expression by siRNA decreased tumorcell proliferation and enhanced apoptosis [7]. And more importantly, elevated G6PD activities have been found in various human cancers, including bladder cancer [8], renal cell carcinoma [9], ovarian cancer [10], fibrosarcoma [11], breast cancer [12], endometrial carcinoma [13], cervical caricinoma [14], prostatic carcinoma [15,16], and lung carcinoma [17]. However, there is no large sample report about the expression and clinical significance of G6PD in human gastric cancer progression and prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Overexpression of G6PD is associated with poor clinical outcome in gastric cancer

et al. 2011

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This study aims to investigate the expression and significance of glucose-6-phosphate dehydrogenase (G6PD) in human gastric cancer progression and prognosis. Using immunohistochemistry and real-time RT-PCR assay, we identified abnormally elevated expression of G6PD in gastric cancer tissues compared to paired normal stomach mucosa tissues in 24 patients (p < 0.05). In order to investigate the correlations between G6PD and the clinicopathological features of gastric cancer, the expression of G6PD in 167 patients with gastric cancer were detected by immunohistochemistry, and the results showed that overexpression of G6PD was associated with the size of tumor (p = 0.039), depth of invasion (p = 0.039), lymph node metastasis (p = 0.044), distant metastasis (p = 0.003), TNM stage (p = 0.030), and survival rate (p = 0.010). Further, Cox multivariates analysis indicated that G6PD expression level was an independent prognostic factor for patients after radical resection (p = 0.013). In conclusion, overexpression of G6PD is closely related to progression of gastric cancer, and might be regarded as an independent predictor of poor prognosis for gastric cancer.

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Overexpression of G6PD is associated with poor clinical outcome in gastric cancer

et al. 2011

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“…In fact, both G6PD and 6PGD have been shown to be increased in cervical carcinoma (32, 34, 36), as well as in lung tumors (82). The critical role of 6PGD in cancer cell proliferation has been described in non-small cell lung carcinoma.…”

Section: -Phosphogluconate Dehydrogenasementioning

confidence: 99%

Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma

2017

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In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined. The pentose phosphate pathway (PPP) is one of the fundamental components of cellular metabolism crucial for cancer cells. This review will discuss recent findings regarding the involvement of PPP enzymes in several types of cancer, with a focus on hepatocellular carcinoma (HCC). We will pay considerable attention to the involvement of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the PPP. Subsequently, we discuss the inhibition of the PPP as a potential therapeutic strategy against cancer, in particular, HCC.

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“…1). Although protective against oxidative stress, this response may enable the rapid proliferation of cancer cells even in adverse environments (10,25).…”

Section: Oxidative Stress and Neonatal Lung Injurymentioning

confidence: 99%

“…Nevertheless, the same genes downstream of Nrf2 may alter cellular metabolic fate and enable lung cancer cells to grow more rapidly (25). This will be discussed briefly in a later section.…”

Section: Figmentioning

confidence: 99%

Heme Oxygenase in Neonatal Lung Injury and Repair

Dennery

2014

Antioxidants & Redox Signaling

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Significance: Premature and sick neonates are often exposed to high concentrations of oxygen, which results in lung injury and long-term adverse consequences. Nevertheless, neonates are more tolerant to hyperoxia than are adults. This may be, in part, explained by the high lung content of heme oxygenase-1 (HO-1), the rate-limiting enzyme in the degradation of heme and an important stress protein. The abundance of HO-1 dictates its cytoprotective and deleterious effects. Interestingly, in response to hyperoxia, lung HO-1 mRNA is not further up-regulated in neonates, suggesting that lung HO-1 gene expression is tightly regulated so as to optimize cytoprotection when faced with an oxidative stress such as hyperoxia. Recent Advances: In addition to the lack of induction of HO-1 mRNA, neonatal lung HO-1 protein is observed in the nucleus in neonatal mice exposed to hyperoxia but not in adults, which is further evidence for the developmental regulation of HO-1. Nuclear HO-1 had unique properties independent of its enzymatic activity. In addition, there has been increasing evidence that nuclear HO-1 contributes to cellular proliferation and malignant transformation in several human cancers. Critical Issues: Since HO-1 has dual effects in cytoprotection and cellular proliferation, the titration of HO-1 effects is critical to ensure beneficial actions against oxidative stress. Future Directions: Much more has to be understood about the specific roles of HO-1 so as to manipulate its abundance and/or nuclear migration to maximize the therapeutic benefit of this pleiotropic protein in the neonatal lung.

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Hexose Monophosphate Shunt Enzymes in Lung Tumors from Normal and Glucose-6-Phosphate-Dehydrogenase-Deficient Subjects

Cited by 27 publications

References 14 publications

Overexpression of G6PD is associated with poor clinical outcome in gastric cancer

Overexpression of G6PD is associated with poor clinical outcome in gastric cancer

Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma

Heme Oxygenase in Neonatal Lung Injury and Repair

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