Hexadecane enhances non-biliary, intestinal excretion of stored hexachlorobenzene by rats

Chlorinated paraffins: Disposition of a highly chlorinated polychlorohexadecane in mice and quail

“…dosed mice (unpublished results). An excretion of labelled substance from the body compartment directly to the intestinal contents via the intestinal wall, as suggested for hexachlorobenzene by, e.g., Rozman et al (1982) and for chlordecone by Bungay et al (1980), may possibly also contribute to the fecal excretion of PCHD. In addition, two other excretion routes were observed in quail, namely via the egg yolk and the uropygial gland.…”

Chlorinated paraffins: Disposition of a highly chlorinated polychlorohexadecane in mice and quail

“…dosed mice (unpublished results). An excretion of labelled substance from the body compartment directly to the intestinal contents via the intestinal wall, as suggested for hexachlorobenzene by, e.g., Rozman et al (1982) and for chlordecone by Bungay et al (1980), may possibly also contribute to the fecal excretion of PCHD. In addition, two other excretion routes were observed in quail, namely via the egg yolk and the uropygial gland.…”

Physiological Pharmacokinetic Model of Hexachlorobenzene in the Rat

“…NUMEROUS studies have been performed on the absorption, distribution, and elimination of hexachlorobenzene (HCB) in rats (Koss and Koransky 1975;Richter and Schafer 1981;Rozman et al 1982Rozman et al , 1983Scheufler and Rozman 1984a, b;Rozman et al 1985;Scheufler and Rozman 1984a), and rhesus monkeys (Rozman et al 1978(Rozman et al , 1981(Rozman et al , 1983. However, these data have not been developed into a unifying model that will predict HCB pharmacokinetics in the other species, including the human.…”

Chlorinated paraffins: Disposition of a highly chlorinated polychlorohexadecane in mice and quail

“…dosed mice (unpublished results). An excretion of labelled substance from the body compartment directly to the intestinal contents via the intestinal wall, as suggested for hexachlorobenzene by, e.g., Rozman et al (1982) and for chlordecone by Bungay et al (1980), may possibly also contribute to the fecal excretion of PCHD. In addition, two other excretion routes were observed in quail, namely via the egg yolk and the uropygial gland.…”

Physiological Pharmacokinetic Model of Hexachlorobenzene in the Rat

“…NUMEROUS studies have been performed on the absorption, distribution, and elimination of hexachlorobenzene (HCB) in rats (Koss and Koransky 1975;Richter and Schafer 1981;Rozman et al 1982Rozman et al , 1983Scheufler and Rozman 1984a, b;Rozman et al 1985;Scheufler and Rozman 1984a), and rhesus monkeys (Rozman et al 1978(Rozman et al , 1981(Rozman et al , 1983. However, these data have not been developed into a unifying model that will predict HCB pharmacokinetics in the other species, including the human.…”

Chlorinated paraffins: Disposition of a highly chlorinated polychlorohexadecane in mice and quail

“…dosed mice (unpublished results). An excretion of labelled substance from the body compartment directly to the intestinal contents via the intestinal wall, as suggested for hexachlorobenzene by, e.g., Rozman et al (1982) and for chlordecone by Bungay et al (1980), may possibly also contribute to the fecal excretion of PCHD. In addition, two other excretion routes were observed in quail, namely via the egg yolk and the uropygial gland.…”

Physiological Pharmacokinetic Model of Hexachlorobenzene in the Rat

“…NUMEROUS studies have been performed on the absorption, distribution, and elimination of hexachlorobenzene (HCB) in rats (Koss and Koransky 1975;Richter and Schafer 1981;Rozman et al 1982Rozman et al , 1983Scheufler and Rozman 1984a, b;Rozman et al 1985;Scheufler and Rozman 1984a), and rhesus monkeys (Rozman et al 1978(Rozman et al , 1981(Rozman et al , 1983. However, these data have not been developed into a unifying model that will predict HCB pharmacokinetics in the other species, including the human.…”