Heterotopic Ossification in Total Cervical Artificial Disc Replacement

Mehren, Christoph; Suchomel, Petr; Grochulla, Frank; Barša, Pavel; Sourkova, Petra; Hradil, Jan; Korge, Andreas; Mayer, H. M.

doi:10.1097/01.brs.0000245852.70594.d5

Cited by 251 publications

(167 citation statements)

References 27 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…The extent of heterotopic ossifications (HO) was graded according to the modified McAfee classification system for lumbar disc prostheses as previously described by Mehren/ Suchomel et al (Table 2) [11].…”

Section: Methodsmentioning

confidence: 99%

“…Qureshi et al analysed the cost-effectiveness comparing single level TDR and ACDF and conclude also that cTDR and ACDF are cost-effective procedures, but cTDR must remain functional for at least 14 years to establish greater cost-effectiveness than ACDF [34]. The appearance of HO right up to solid fusion (Grade 4) is a well known complication in cervical total disc replacement which can affect the motion, respectively, the function of the prosthesis [31,32,35] regardless the implant-type [7,11,17,27,28,[36][37][38][39]. The progression of HO into higher grades over time was also seen in other studies [28,32].…”

Section: Adjacent Segment Degenerationmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and radiological outcome at 10 years of follow-up after total cervical disc replacement

et al. 2017

Self Cite

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Section: Adjacent Segment Degenerationmentioning

confidence: 99%

Clinical and radiological outcome at 10 years of follow-up after total cervical disc replacement

et al. 2017

Self Cite

View full text Add to dashboard Cite

“…Nonconstrained devices have no mechanical stop and extremes of motion are prevented by the perispinal soft tissue and inherent compression across the disc space [14]. Previously, reports regarding fusion (Mehren grade 4) have focused mainly on semiconstrained devices [15]. Few studies have assessed the occurrence of heterotopic ossification and complete fusion in cervical nonconstrained arthroplasty [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Heterotopic ossification and clinical outcome in nonconstrained cervical arthroplasty 2 years after surgery: the Norwegian Cervical Arthroplasty Trial (NORCAT)

et al. 2016

View full text Add to dashboard Cite

Purpose Heterotopic ossification is a phenomenon in cervical arthroplasty. Previous reports have mainly focused on various semiconstrained devices and only a few publications have focused on ossification around devices that are nonconstrained. The purpose of this study was to assess the occurrence of heterotopic ossification around a nonconstrained cervical device and how it affects clinical outcome 2 years after surgery. Methods Thirty-seven patients were included from a larger cohort of a randomized controlled trial (NORCAT) which compared single-level cervical arthroplasty with fusion. The occurrence of heterotopic ossification was assessed with a CT scan and two neuroradiologists determined its degree. For grading, we used the Mehren/Suchomel classification system (grade 0-4). The patients were divided by level of ossification, low grade (0-2) or high grade (3-4), and clinical outcomes were compared.Self-rated disability for neck and arm pain (Neck Disability Index), health-related quality of life (the Short Form-36 and EuroQol-5D), and pain (the Numeric Rating Scale 11) were used as clinical outcome measures. Results Heterotopic ossification was encountered in all patients 2 years after surgery. Complete fusion (grade 4) was found in 16 % of participants, and high-grade ossification (grade 3-4) occurred in 62 %. The remaining patients were classified as having low-grade ossification (grade 2). There were no differences in the clinical outcomes of patients with low-and high-grade ossification. Conclusion High-grade heterotopic ossification and spontaneous fusion 2 years after surgery were seen in a significant number of patients. However, the degree of ossification did not influence the clinical outcome.

show abstract

“…The Neck Disability Index (NDI) is the most widely-used neck-specific measure in published intervention studies (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). It has been cited in over 251 scientific articles and translated into more than 20 languages (available at http:// www.cmcc.ca/Portals/0/pdfs/rs_%20NDI_manual.pdf).…”

Section: Introductionmentioning

confidence: 99%

Rasch analysis provides new insights into the measurement properties of the neck disability index

Velde

Beaton

Hogg-Johnston

et al. 2009

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. The most widely used neck-specific measure in intervention trials is the 10-item Neck Disability Index (NDI), which is assumed to be a unidimensional interval scale, as shown by how NDI data are scored, analyzed, and interpreted. Our objective was to use modern measurement methods to test this assumption (and thereby to also test the validity of calculating summed scores and parametric statistics on NDI data) through Rasch analysis. Methods. NDI data from 521 trial subjects with neck pain were fit to the Rasch model. We examined threshold ordering of NDI items, fit of data to model expectations, presence of differential item functioning, and whether or not the set of NDI items collectively measure a single construct, which is a requirement for calculating summative scores.Results. There was a lack of fit of data to the Rasch model ( 2 ‫؍‬ 140.35, 70 df; P < 0.001). Five items (personal care, lifting, headaches, work, and recreation) had disordered response thresholds. Differential item functioning was detected for age and sex. The NDI items did not contribute to a single construct. Unidimensionality and interval scaling were achieved by removing 2 of the 10 items (resulting in the NDI-8), and converting NDI-8 ordinal (paper) summative scores to NDI-8 interval (Rasch-weighted) scores. Conclusion. As originally proposed and conventionally used, the NDI is not a unidimensional scale, and has only ordinal scaling. This raises fundamental doubts about the practice of calculating change scores and other parametric statistics on NDI data. A revised 8-item version provides unidimensional interval-level measurement of neck pain disability.

show abstract

Heterotopic Ossification in Total Cervical Artificial Disc Replacement

Cited by 251 publications

References 27 publications

Clinical and radiological outcome at 10 years of follow-up after total cervical disc replacement

Clinical and radiological outcome at 10 years of follow-up after total cervical disc replacement

Heterotopic ossification and clinical outcome in nonconstrained cervical arthroplasty 2 years after surgery: the Norwegian Cervical Arthroplasty Trial (NORCAT)

Rasch analysis provides new insights into the measurement properties of the neck disability index

Contact Info

Product

Resources

About