Heteromeric three-stranded coiled coils designed using a Pb(ii)(Cys)3 template mediated strategy

The Fe‐N‐C Nanozyme with Both Accelerated and Inhibited Biocatalytic Activities Capable of Accessing Drug–Drug Interactions

“…In this sense,Fe-N-C combined the advantages of both heterogeneous nanozymes and homogeneous molecules-based artificial enzymes. [28] As more patients take two or more drugs and ad iversity of foods,t he even increased risk of drug-drug interaction appeals for rapid and low-cost checking approaches.N evertheless,o wing to timeconsuming and high cost, the traditional cell culture route by evaluation of drug-metabolizing CYP are challenged, particularly for small molecules. [4b] Theu nique feature of Fe-N-C with both accelerated and inhibited biocatalytic CYP-like behaviors in abiological context would provide an alternative potential solution for drug-drug interaction studies.Notably, rather than actually replacing ac linical trial, this method would replace astudy that was never going to happen, which can guide dosing and predict outcomes.…”

Synergistic Interactions Are Prevalent in Catalytic Amyloids

“…However, the question remained whether the synergistic relationship between Arg‐ and Tyr‐containing peptides observed in our previous work is only an isolated example, or if it is representative of typical behavior in catalytic amyloids. A broader investigation of the mixing behavior in catalytic amyloids would allow us to determine the general applicability of short catalytic amyloids to form synergistic mixtures, something which has been observed in other model catalytic systems, and has been shown to substantially increase reactivity in other de novo hydrolytic systems . In addition to the fundamental importance of this question for the elucidation of the origins of life, the combinatorial investigation of short model complexes can help refine strategies for peptide and protein design…”

The Fe‐N‐C Nanozyme with Both Accelerated and Inhibited Biocatalytic Activities Capable of Accessing Drug–Drug Interactions

“…Referring to many other nanozymes, they also have some enzyme‐like functions, but few of them also have enzyme‐like molecular structures (see control experiments of Fe‐containing nanomaterial, for example, Fe 3 O 4 nanoparticles and Fe‐free counterpart, for example, N‐doped carbon in the Supporting Information, Figure S13). In this sense, Fe‐N‐C combined the advantages of both heterogeneous nanozymes and homogeneous molecules‐based artificial enzymes . As more patients take two or more drugs and a diversity of foods, the even increased risk of drug–drug interaction appeals for rapid and low‐cost checking approaches.…”