Heterogeneous porous PLLA/PCL fibrous scaffold for bone tissue regeneration

Chen, Meng; Tang, Dexin; Liu, Xuzhao; Meng, Jinmin; Wei, Wenyuan; Gong, Rong; Li, Jiashen

doi:10.1016/j.ijbiomac.2023.123781

Cited by 27 publications

(15 citation statements)

References 44 publications

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“…For PLLA, decomposition begins at about 290 °C, reaching a maximum weight loss rate at around 350 °C. These thermal decomposition characteristics of PLLA align well with values reported in previous research . In case of the PLLA/Cu (in Cu) and PLLA/Cu (in Vc) samples, the contents of Cu nano/microparticles can be estimated based on the residual amounts, as shown by the TGA measurements .…”

Section: Resultssupporting

confidence: 89%

Hierarchically Porous, Superhydrophobic PLLA/Copper Composite Fibrous Membranes for Air Filtration

Huang,

Meng,

Liao

et al. 2024

ACS Appl. Polym. Mater.

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Epidemics such as pulmonary tuberculosis and pertussis can spread quickly through the air in enclosed or small spaces. Most of these diseases are caused by various bacteria. In hospitals, nursing homes, and biology laboratories, the requirement for air quality is often high. Particulate air filters can remove infectious bacteria from the air, making them a good choice for local ventilation systems to capture and remove bacteria or other pathogenic microbes. With high surface area, electrospun poly(l-lactic acid) (PLLA) fibrous membranes have the ability to capture small particles like bacteria. Moreover, copper has significant antimicrobial properties. In this Letter, we present a hierarchically porous PLLA membrane created through electrospinning and acetone treatment. Additionally, we describe two methods for loading copper particles onto the hierarchically porous PLLA membrane, thereby providing capabilities for capturing and killing bacteria. The experiments demonstrated that the final PLLA/Cu composite fibrous membranes exhibit not only excellent air permeability but also remarkable antimicrobial performance while maintaining bendability and superhydrophobic ability. This study provides a simple process, low energy cost, and environmentally friendly method to produce the copper-coated PLLA membrane, which is especially suitable for potential applications in high-flux filtration equipment in hospitals, nursing homes, and biology laboratories.

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Section: Resultssupporting

confidence: 89%

Hierarchically Porous, Superhydrophobic PLLA/Copper Composite Fibrous Membranes for Air Filtration

Huang,

Meng,

Liao

et al. 2024

ACS Appl. Polym. Mater.

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“…Ideal scaffold materials for regenerating new bone tissue should possess high specific surface areas and porosity, thereby promoting cell attachment, proliferation, and differentiation. 42,43 With the increase in the strut diameter, a decrease in the specific surface area of the BISs became apparent, as illustrated in Figure 5A. Moreover, the results unveiled similar specific surface areas across different α values within the d range of 0.3 to 0.55 mm, closely mirroring the specific surface area characteristics observed in the bone unit structure (4−11 mm −1 ).…”

Section: Structural Parameters About αsupporting

confidence: 56%

“…The specific surface area, quantified as the ratio of the surface area to biomaterial volume (BS/BV), was assessed across different parameter structures. Ideal scaffold materials for regenerating new bone tissue should possess high specific surface areas and porosity, thereby promoting cell attachment, proliferation, and differentiation. , With the increase in the strut diameter, a decrease in the specific surface area of the BISs became apparent, as illustrated in Figure A. Moreover, the results unveiled similar specific surface areas across different α values within the d range of 0.3 to 0.55 mm, closely mirroring the specific surface area characteristics observed in the bone unit structure (4–11 mm –1 ). , Cortical bone typically exhibits a porosity range of 5–15%, whereas cancellous bone displays a porosity range of 40–95% .…”

Section: Results and Discussionmentioning

confidence: 60%

Bamboo-Inspired Porous Scaffolds for Advanced Orthopedic Implants: Design, Mechanical Properties, and Fluid Characteristics

Chen,

Liu,

et al. 2024

ACS Biomater. Sci. Eng.

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In orthopedic implant development, incorporating a porous structure into implants can reduce the elastic modulus to prevent stress shielding but may compromise yield strength, risking prosthesis fracture. Bamboo’s natural structure, with its exceptional strength-to-weight ratio, serves as inspiration. This study explores biomimicry using bamboo-inspired porous scaffolds (BISs) resembling cortical bone, assessing their mechanical properties and fluid characteristics. The BIS consists of two 2D units controlled by structural parameters α and β. The mechanical properties, failure mechanisms, energy absorption, and predictive performance are investigated. BIS exhibits mechanical properties equivalent to those of natural bone. Specifically, α at 4/3 and β at 2/3 yield superior mechanical properties, and the destruction mechanism occurs layer by layer. Besides, the Gibson–Ashby models with different parameters are established to predict mechanical properties. Fluid dynamics analysis reveals two high-flow channels in BISs, enhancing nutrient delivery through high-flow channels and promoting cell adhesion and proliferation in low-flow regions. For wall shear stress below 30 mPa (ideal for cell growth), α at 4/3 achieves the highest percentage (99.04%), and β at 2/3 achieves 98.46%. Permeability in all structural parameters surpasses that of human bone. Enhanced performance of orthopedic implants through a bionic approach that enables the creation of pore structures suitable for implants.

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“…[61][62][63][64][65][144][145][146] PLLA has been extensively researched and employed in various biomedical applications, including tissue engineering, drug delivery, and aesthetic medicine. [147][148][149][150][151] Its biodegradability and mechanical properties are modifiable and depend on its molecular weight, crystallinity, and aging characteristics. 143,152 Under physiological conditions, PLLA degrades slowly into non-toxic L-lactic acid, which can be excreted by the body as H 2 O and CO 2.…”

Section: Poly-ε-caprolactonementioning

confidence: 99%

“…Among them, PLLA is an alpha hydroxy acid polymer with the l ‐enantiomeric structure of lactic acid, and it has high tensile strength, good biocompatibility, thermal plasticity, and easy processability 61–65,144–146 . PLLA has been extensively researched and employed in various biomedical applications, including tissue engineering, drug delivery, and aesthetic medicine 147–151 . Its biodegradability and mechanical properties are modifiable and depend on its molecular weight, crystallinity, and aging characteristics 143,152 .…”

Section: Application Of Biodegradable Polymers In Absorbable Cardiac ...mentioning

confidence: 99%

Progress of biodegradable polymer application in cardiac occluders

Xu,

Fa,

Yang

et al. 2023

J Biomed Mater Res

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Cardiac septal defect is the most prevalent congenital heart disease and is typically treated with open‐heart surgery under cardiopulmonary bypass. Since the 1990s, with the advancement of interventional techniques and minimally invasive transthoracic closure techniques, cardiac occluder implantation represented by the Amplazter products has been the preferred treatment option. Currently, most occlusion devices used in clinical settings are primarily composed of Nitinol as the skeleton. Nevertheless, long‐term follow‐up studies have revealed various complications related to metal skeletons, including hemolysis, thrombus, metal allergy, cardiac erosion, and even severe atrioventricular block. Thus, occlusion devices made of biodegradable materials have become the focus of research. Over the past two decades, several bioabsorbable cardiac occluders for ventricular septal defect and atrial septal defect have been designed and trialed on animals or humans. This review summarizes the research progress of bioabsorbable cardiac occluders, the advantages and disadvantages of different biodegradable polymers used to fabricate occluders, and discusses future research directions concerning the structures and materials of bioabsorbable cardiac occluders.

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Heterogeneous porous PLLA/PCL fibrous scaffold for bone tissue regeneration

Cited by 27 publications

References 44 publications

Hierarchically Porous, Superhydrophobic PLLA/Copper Composite Fibrous Membranes for Air Filtration

Hierarchically Porous, Superhydrophobic PLLA/Copper Composite Fibrous Membranes for Air Filtration

Bamboo-Inspired Porous Scaffolds for Advanced Orthopedic Implants: Design, Mechanical Properties, and Fluid Characteristics

Progress of biodegradable polymer application in cardiac occluders

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