Heterogeneous expression of HLA-G1, -G2, -G5, -G6, and -G7 in myeloid and plasmacytoid dendritic cells isolated from umbilical cord blood

Román, Ángela; Rodríguez, Miguel; Herráiz, M.; Zurdo, Julia; Cervera, Isabel; Peñaloza, J.; Vidart, José Antonio; Martı́nez-Laso, Jorge

doi:10.1016/j.humimm.2008.12.001

Cited by 13 publications

(12 citation statements)

References 49 publications

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“…The immuno-regulatory properties of UCBs are partly related to the presence of soluble molecules, such as HLA-G antigens. In particular, HLA-G molecules were identified in UCBs [13], with MDCs and PDCs as resident producers of HLA-G [15]. CD34 ϩ cells were reported to be HLA-G negative [14], despite their implication in UCB engraftment.…”

Section: Discussionmentioning

confidence: 99%

“…HLA-G expression was observed in UCBs [13,14] with myeloid (MDCs) and plasmacytoid (PDCs) dendritic cells as resident producers of HLA-G molecules [15], whereas CD34 ϩ fraction did not present any HLA-G-specific mRNA [14]. The CD34 antigen identifies a cellular population that comprises the more primitive hematopoietic progenitor cells present in UCB.…”

Section: Introductionmentioning

confidence: 98%

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Umbilical cord blood CD34+cell–derived progeny produces human leukocyte antigen–G molecules with immuno-modulatory functions

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Umbilical cord blood CD34+cell–derived progeny produces human leukocyte antigen–G molecules with immuno-modulatory functions

et al. 2012

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“…That the diminished GvHD response could also in part be due to the differences in the DC populations found in the two tissues, is demonstrated by the different expression of the human leukocyte antigen ( Hla )-G [66] and the lower expression of cell-surface markers involved in DC/ T-cell interaction [67]. Cb monocytes and Cb CD16 + CD14 −/low DC produce lower basal levels of cytokines (Il-1 β , Il-6, Il-12, and Tnf - α ), when compared to peripheral blood, with identical responses to stimulation, reflecting the reduced antigen stimulation in utero , but suggesting that the ability to respond to stimulation shown by monocytes and CD16 + CD14 −/low DCs reflects cellular maturity [5].…”

Section: Dendritic Cells In Cord Blood Transplantationmentioning

confidence: 99%

Dendritic Cells in Cord Blood Transplantation: A Review

Pereira

Paiva

2011

Stem Cells International

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Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells derived from hematopoietic progenitors that bridge the transition between the innate and adaptive immune responses, while maintaining self-tolerance and Th1/Th2 homeostasis, by priming other cells in either an immunogenic or tolerogenic direction. Through their role in both innate and adaptive immunity, DCs play a major part in transplant engraftment and rejection and in graft-versus-host disease (GvHD). Preferentially tolerogenic or immunogenic DC subtypes offer targets for immunotherapy, to optimize transplant success rates and prolong disease-free and overall survival. Cord blood DCs are immature and preferentially tolerogenic, due to maternal-fetal tolerance, leading to better graft acceptance and immune reconstitution and explaining the lower incidence and severity of GvHD in CB transplantation, despite donor-host mismatching. Manipulation of DC maturation and cell loading with tumor-antigens can direct antitumor immunity and target minimal residual disease, as demonstrated for acute myeloid leukemia, optimizing the graft-versus-leukemia effect.

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“…The nonclassical MHC class I molecule HLA-G may have nonimmune functions relating to angiogenesis and placentation, but most evidence suggests that HLA-G may be a part of the mechanism that enables trophoblasts to invade without being attacked by the lymphocyte population, decidual NK cells [3,8,9], and protects fetal cells from lysis by maternal uterine NK cells [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…The expression of HLA-G is normally restricted to the placenta during pregnancy, where it is found on trophoblasts, fetal endothelial and epithelial cells, and noninvasive cytotrophoblsats cells, specifically those at the maternal/fetal interface [8,9].…”

Section: Introductionmentioning

confidence: 99%

Umbilical Serum sHLA-G Levels in Preeclamptic Pregnancies with and without Intrauterine Fetal Growth Restriction: A Comparison with Normotensive Pregnancies with Isolated IUGR and Healthy Controls

Laskowska

Oleszczuk

2011

ISRN Immunology

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The aim of this study was the analysis of the umbilical cord serum sHLA-G levels in pregnancies complicated by severe preeclampsia and/or IUGR. Patients and Methods. The study was carried out on 12 preeclamptic patients with appropriate-for-gestational-age weight infants, 14 pregnant patients with severe preeclampsia complicated by IUGR, 7 normotensive patients with isolated IUGR, and 22 healthy controls with uncomplicated pregnancies. Results. Our study revealed higher umbilical serum levels of sHLA-G in preeclamptic pregnancies complicated by IUGR and decreased in the preeclamptic women with the normal fetal growth. The pregnant normotensive patients with isolated IUGR revealed the same levels of sHLA-G as observed in healthy pregnant controls. Conclusions. Lower levels of sHLA-G observed in preeclamptic pregnancies without IUGR may lead to excessive maternal immune reaction against the fetus. Higher levels of sHLA-G in preeclamptic pregnancies with IUGR may reflect the excessive releasing of this molecule to protect fetus, but it may be insufficient to balance disturbed fetomaternal immune relationship. The lack of association with normotensive pregnancies complicated by isolated IUGR may suggest that a different pathomechanism is involved in the impairment of intrauterine fetal growth in both patient groups with pregnancies complicated by isolated IUGR and in the course of preeclampsia.

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Heterogeneous expression of HLA-G1, -G2, -G5, -G6, and -G7 in myeloid and plasmacytoid dendritic cells isolated from umbilical cord blood

Cited by 13 publications

References 49 publications

Umbilical cord blood CD34+cell–derived progeny produces human leukocyte antigen–G molecules with immuno-modulatory functions

Umbilical cord blood CD34+cell–derived progeny produces human leukocyte antigen–G molecules with immuno-modulatory functions

Dendritic Cells in Cord Blood Transplantation: A Review

Umbilical Serum sHLA-G Levels in Preeclamptic Pregnancies with and without Intrauterine Fetal Growth Restriction: A Comparison with Normotensive Pregnancies with Isolated IUGR and Healthy Controls

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