Heterogeneity of primary malignant melanomas in oral mucosa: An analysis of 43 cases in Japan

Umeda, Masahiro; Mishima, Yutaka; Teranobu, Osamu; Nakanishi, Koichi; Shimada, Keikichi

doi:10.3109/00313028809059498

Cited by 34 publications

(14 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to Caucasians, Japanese people show a relatively high frequency of malignant melanoma in the oral cavity 13 . Cutaneous melanoma is classified into four major types: lentigo maligna melanoma (LMM), superficial spreading melanoma (SSM), nodular melanoma (NM), and acral lentiginous melanoma (ALM).…”

Section: Discussionmentioning

confidence: 93%

“…The Western Society of Teachers of Oral Pathology (WESTOP) stated that oral melanomas appeared to be similar to acral lentiginous melanoma (ALM) of the skin, but that the particularly poor prognosis of oral melanomas was unlike that of cutaneous lesions, and until detailed 5 prospective studies were completed, it would seem appropriate to classify oral lesions separately from cutaneous lesions 12 . On the other hand, Umeda et al reported that most oral melanomas showed a radial growth phase identical to that of ALM both clinically and histologically, and that the prognosis of oral melanoma was not as poor as reported earlier, if adequate therapy was provided [13][14][15][16] . However, patients with recurrent malignant melanoma are not curable in most cases, so the therapeutic strategy for recurrent melanoma is controversial.…”

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Recurrent malignant melanoma of the palate successfully treated by gamma knife radiosurgery

et al. 2013

Self Cite

View full text Add to dashboard Cite

The prognosis of oral malignant melanoma is reported to be extremely poor. In this report, a patient with recurrent oral melanoma in the skull base who was treated successfully with gamma knife radiosurgery (GKS) is described.A 53-year-old man was referred with a chief complaint of a mass of the hard palate. Histological diagnosis of the biopsy specimen was malignant melanoma. He underwent a wide local resection with bilateral neck dissection, followed by immunochemotherapy with DAV-Feron.At 13 months after the surgery, recurrent tumor was found in the post-lower region of the nasal septum. The patient underwent resection of the lesion followed by immunochemotherapy with DAC-Tam-Feron. However, at 9 months after the last chemotherapy, local recurrence again occurred in the skull base, and he underwent GKS.The recurrent tumor disappeared completely and he is well with no signs of recurrence or metastasis at 57 months after GKS.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 95%

Recurrent malignant melanoma of the palate successfully treated by gamma knife radiosurgery

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…The frequency of malignant melanoma of the oral cavity is relatively high among Japanese people in contrast to that in Caucasian populations 31,50 . There are four main types of cutaneous melanoma: lentigo maligna melanoma (LMM), superficial spreading melanoma (SSM), nodular melanoma (NM), and acral lentiginous melanoma (ALM) 31 .…”

mentioning

confidence: 92%

“…The classification and treatment of oral melanoma remains controversial. Most oral mucosal melanomas have radial growth phases similar to those of ALM of the skin 47,50 . Some authors have advocated classifying oral melanoma separately from cutaneous melanoma because of the poor prognosis of oral melanoma patients.…”

mentioning

confidence: 96%

The influence of surgical procedure and the effect of chemotherapy on nodal and distant metastases of human malignant melanomas that have been grafted into nude mice

Oguni

Umeda

Satō

et al. 2010

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

“…Another study demonstrated that oral melanomas are very rare, accounting for only 1.6% of 7500 melanomas reported [15] . Racial, cultural or geographic factors may predispose subjects to the this malignancy [16,17] . The mean age at diagnosis of patients with oral melanoma is 55 years (range, 40-70 years) [18][19][20][21] , although in some researches this malignancy appeared with a peak incidence in the age range 60-80 years [4,[19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

Malignant Mucosal Melanoma of the Head and Neck Diagnosed in an Iranian Population over an 11-Year Period

Pour¹,

Rad²,

Zarei³

et al. 2009

American J. of Applied Sciences

View full text Add to dashboard Cite

Problem statement: Mucosal Melanoma of the Head and Neck (MMHN) is a rare lethal disease. This malignancy accounts for half of all mucosal melanomas, occurring mainly in the nasal cavity, oral cavity and pharynx. They appear with equal gender distribution and with a peak incidence in the age range 60-80 years. The aim of this study was to investigate incidence, sex, age and site distribution of MMHN in the Kerman province during the time period from March 1991-2002. Approach: Documents and records of 52 patients with MMHN diagnosed from March 1991-2002 were reviewed. The patients were analyzed according to gender, age and location of the tumor. Data included in the present retrospective study were analyzed by SPSS13.5 statistical software, t-test and chi-square. Results: During this time period, 52 cases (25 men and 27 women) of MMHN were diagnosed. The age range was 7-84 years. The nasal cavity (55.8%) was the most affected site. The palate and upper gingiva was the most common site in the oral cavity (8 patients, 88.8%). Survivals 5 years in MMHN patients were 27% and patients with mucosal melanoma of oral cavity have an 11%, 5 year survival rate. Conclusion: Comparison between the findings of this study with the results obtained by other investigators showed a relative consistency.

show abstract

Heterogeneity of primary malignant melanomas in oral mucosa: An analysis of 43 cases in Japan

Cited by 34 publications

References 34 publications

Recurrent malignant melanoma of the palate successfully treated by gamma knife radiosurgery

Recurrent malignant melanoma of the palate successfully treated by gamma knife radiosurgery

The influence of surgical procedure and the effect of chemotherapy on nodal and distant metastases of human malignant melanomas that have been grafted into nude mice

Malignant Mucosal Melanoma of the Head and Neck Diagnosed in an Iranian Population over an 11-Year Period

Contact Info

Product

Resources

About