Heterochronies in skull development of Lake Tana large African barbs (Labeobarbus; Cyprinidae; Teleostei)

Смирнов, С. В.; Borisov, V. B.; Abdissa, Belay; Shkil, F. N.

doi:10.1111/j.1439-0426.2012.01993.x

Cited by 10 publications

(5 citation statements)

References 27 publications

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“…The reactions of skull bones to TH changes are more pronounced. The cranial development of barbs has two peaks of explosive osteogenesis separated by a stasis stage – period when new skull bones do not arise, but earlier formed bones continue to grow (Shkil et al., 2010b; Smirnov et al., 2012). In larvae reared under high TH level, stasis period shows reduction to the point of complete disappearance.…”

Section: Resultsmentioning

confidence: 99%

Thyroid hormone in skeletal development of cyprinids: effects and morphological consequences

Shkil

Капитанова

Borisov

et al. 2012

Journal of Applied Ichthyology

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Summary The effects of thyroid hormone (TH) level changes on skeletal development were studied in cyprinids Labeobarbus intermedius (Barbinae) and Danio rerio (Danioninae). TH was revealed to influence development of a skull, axial skeleton, paired fins and girdles, and squamation. Usually, high TH‐level promotes the premature onset and acceleration of ontogenetic processes, whereas TH‐deficiency delays and retards them. However, skeletal elements differ in TH‐responsiveness. Alterations of TH level induce developmental changes in some structures but do not cause any changes in others. As a result, the normal sequence of ontogenetic events and the temporal interrelations between ontogenetic processes undergo changes resulting in changes in adult morphology.

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Section: Resultsmentioning

confidence: 99%

Thyroid hormone in skeletal development of cyprinids: effects and morphological consequences

Shkil

Капитанова

Borisov

et al. 2012

Journal of Applied Ichthyology

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“…It worthy to note, that zebrafish’s critical window to a large extend coincides with the period of increased developmental plasticity in adaptively radiating cyprinids, in particular the large African barbs g. Labeobarbus of Lake Tana (Shkil et al, 2015, Smirnov et al, 2012). Moreover, skeletal structures affected by THs during this period in zebrafish play the pivotal role in formation of adaptive phenotypes in various fish taxa and considered as evolutionary targets (Keer et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Effects and phenotypic consequences of transient thyrotoxicosis and hypothyroidism at different stages of zebrafishDanio rerio(Teleostei; Cyprinidae) skeleton development

Borisov,

Shkil

2024

Preprint

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Thyroid hormones (THs) are one of the main regulators of remodeling, homeostasis and development of skeletal tissues in teleosts, and the effects of hypo- and hyperthyroidism on skeleton are among the objectives of research in the fields of fishes development and evolution. However, in most experimental models used, the altered THs status is a constant characteristic of the developing organism, and the observed phenotypic outcomes are the cumulative consequences of multiple THs induced developmental changes. The effects of the transient fluctuations of THs content on the skeleton development have been studied much less. Here, we present experimental data on the developmental effects and phenotypic consequences of transient, pharmacologically induced thyrotoxicosis and hypothyroidism at different stages of zebrafish ossified skeleton patterning. In accordance with the results, skeleton structures differ in the timing and degree of THs sensitivity. Some of them displayed a notable shift in the developmental timing and rate, whereas other demonstrated a subtle or absence of reaction in respond to changes of THs content. The developmental stages also differ in THs sensitivity. A relatively short developmental period has been revealed, during which changes in THs level (mainly thyrotoxicosis) sharply increase the developmental instability and plasticity, leading to phenotypic consequences comparable to those in fish with permanently altered THs status. These findings allow us consider this period as a critical developmental window.Summary statementStudy of the developmental effects and phenotypic consequences of acute transient changes in thyroid hormones content have identified a critical developmental window for zebrafish’s skeletonEthics statementAll procedures with fish were carried out according to the guidelines and following the laws and ethics of the Russian Federation, and approved by the ethics committee of the Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences (Approval ID: N 95 issued on 27.05.2024).

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“…A species flock of Barbus intermedius within the Lake Tana of Africa exhibit a large degree of morphological diversity in recent radiations of this group (Nagelkerke, 1997). This radiation is thought to be due to heterochronic shifts in development between incipient species causing distinct morphotypes (Mina et al., 2001; Smirnov et al, 2012). Like the icefish example above, these fish have increased genetic complexity.…”

Section: Genetic Diversity and Redundancymentioning

confidence: 99%

Comparative genetics of postembryonic development as a means to understand evolutionary change

2012

Journal of Applied Ichthyology

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Summary This review addresses the use of comparative studies of development to help understand the mechanisms underlying the evolution of morphological and physiological diversity. Mutation analysis in experimental model organisms is at the core of our understanding of how development works, and these findings have proven important in the identification and functional support of genetic variations associated with character change in natural populations. However, it has been argued that the essential and pleiotropic effect of many developmentally important genes limits the utility of such mutational study of development toward understanding evolution. Here, I argue that an analysis of the genetic regulation of postembryonic development will refine such comparative analysis. By focusing on late developmental events, one limits the type of genes as well as the types of genetic and developmental changes that may underlie evolutionary change. This may refine the predictive value of such comparative analysis. In this review, I discuss the use of fish as experimental and natural models to address these questions. Fish have several established, experimental models for genetic analysis. Additionally, the morphological and genetic diversity among fish provides a wealth of new models in which to look at the genetic and developmental basis of character change. This broadening of comparative genetic analysis may resolve the bias against genetic ‘monsters’ and what they can tell us about evolutionary change.

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Heterochronies in skull development of Lake Tana large African barbs (Labeobarbus; Cyprinidae; Teleostei)

Cited by 10 publications

References 27 publications

Thyroid hormone in skeletal development of cyprinids: effects and morphological consequences

Thyroid hormone in skeletal development of cyprinids: effects and morphological consequences

Effects and phenotypic consequences of transient thyrotoxicosis and hypothyroidism at different stages of zebrafishDanio rerio(Teleostei; Cyprinidae) skeleton development

Comparative genetics of postembryonic development as a means to understand evolutionary change

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