Hanadie Yousef, Michael J. Conboy, Ju Li, Matthew Zeiderman, Tandis Vazin, Christina Schlesinger, David V. Schaffer, Irina M. Conboy
Abstract:This work builds upon our findings that proteins secreted by hESCs exhibit pro-regenerative activity, and determines that hESC-conditioned medium robustly enhances the proliferation of both muscle and neural progenitor cells. Importantly, this work establishes that it is the proteins that bind heparin which are responsible for the pro-myogenic effects of hESC-conditioned medium, and indicates that this strategy is suitable for enriching the potentially therapeutic factors. Additionally, this work shows that hE…
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