Herpesvirus-like infection in two young boas

Hauser, B.; Fa, Mettler; Rübel, Alex

doi:10.1016/0021-9975(83)90057-9

Cited by 25 publications

(11 citation statements)

References 1 publication

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“…In reptiles, HVs have been detected in lizards [41–48], snakes [49,50], chelonians [51–63] and crocodylians [64,65]. None of the reptilian HVs has yet been assigned to a specific genus in the family Herpesviridae .…”

Section: Herpesviridaementioning

confidence: 99%

Viruses Infecting Reptiles

Marschang

2011

Viruses

182

165

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A large number of viruses have been described in many different reptiles. These viruses include arboviruses that primarily infect mammals or birds as well as viruses that are specific for reptiles. Interest in arboviruses infecting reptiles has mainly focused on the role reptiles may play in the epidemiology of these viruses, especially over winter. Interest in reptile specific viruses has concentrated on both their importance for reptile medicine as well as virus taxonomy and evolution. The impact of many viral infections on reptile health is not known. Koch’s postulates have only been fulfilled for a limited number of reptilian viruses. As diagnostic testing becomes more sensitive, multiple infections with various viruses and other infectious agents are also being detected. In most cases the interactions between these different agents are not known. This review provides an update on viruses described in reptiles, the animal species in which they have been detected, and what is known about their taxonomic positions.

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Section: Herpesviridaementioning

confidence: 99%

Viruses Infecting Reptiles

Marschang

2011

Viruses

182

165

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“…Herpesvirus‐like particles of 125–200 nm in diameter were detected by electron microscopy in young Boa constrictor showing intranuclear inclusion bodies in hepatocytes and necrosis of the liver (Hauser et al., 1983). Organ samples of juvenile boas contained herpesvirus‐like particles of 115–125 nm (Jacobson, 1986).…”

Section: Double‐stranded Dna Virusesmentioning

confidence: 99%

Viruses of Lower Vertebrates

Eßbauer¹,

Ahne

2001

Journal of Veterinary Medicine, Series B

108

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Viruses of lower vertebrates recently became a field of interest to the public due to increasing epizootics and economic losses of poikilothermic animals. These were reported worldwide from both wildlife and collections of aquatic poikilothermic animals. Several RNA and DNA viruses infecting fish, amphibians and reptiles have been studied intensively during the last 20 years. Many of these viruses induce diseases resulting in important economic losses of lower vertebrates, especially in fish aquaculture. In addition, some of the DNA viruses seem to be emerging pathogens involved in the worldwide decline in wildlife. Irido-, herpes- and polyomavirus infections may be involved in the reduction in the numbers of endangered amphibian and reptile species. In this context the knowledge of several important RNA viruses such as orthomyxo-, paramyxo-, rhabdo-, retro-, corona-, calici-, toga-, picorna-, noda-, reo- and birnaviruses, and DNA viruses such as parvo-, irido-, herpes-, adeno-, polyoma- and poxviruses, is described in this review.

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“…Herpesviruses have been reported as significant pathogens of snakes [ 1 , 2 ], lizards [ 3 – 10 ] and alligators [ 11 , 12 ], however, more herpesviruses have been detected in chelonians than in any other reptilian taxa [ 13 ]. Presently, chelonian herpesviruses have been detected and/or isolated from both turtles and tortoises [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

A Genomic Approach to Unravel Host-Pathogen Interaction in Chelonians: The Example of Testudinid Herpesvirus 3

Origgi¹,

Tecilla²,

Pilo³

et al. 2015

PLoS ONE

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We report the first de novo sequence assembly and analysis of the genome of Testudinid herpesvirus 3 (TeHV3), one of the most pathogenic chelonian herpesviruses. The genome of TeHV3 is at least 150,080 nucleotides long, is arranged in a type D configuration and comprises at least 102 open reading frames extensively co-linear with those of Human herpesvirus 1. Consistently, the phylogenetic analysis positions TeHV3 among the Alphaherpesvirinae, closely associated with Chelonid herpesvirus 5, a Scutavirus. To date, there has been limited genetic characterization of TeHVs and a resolution beyond the genotype was not feasible because of the lack of informative DNA sequences. To exemplify the potential benefits of the novel genomic information provided by this first whole genome analysis, we selected the glycoprotein B (gB) gene, for detailed comparison among different TeHV3 isolates. The rationale for selecting gB is that it encodes for a well-conserved protein among herpesviruses but is coupled with a relevant antigenicity and is consequently prone to accumulate single nucleotide polymorphisms. These features were considered critical for an ideal phylogenetic marker to investigate the potential existence of distinct TeHV3 genogroups and their associated pathology. Fifteen captive tortoises presumptively diagnosed to be infected with TeHVs or carrying compatible lesions on the basis of either the presence of intranuclear inclusions (presumptively infected) and/or diphtheronecrotic stomatitis-glossitis or pneumonia (compatible lesions) were selected for the study. Viral isolation, TeHV identification, phylogenetic analysis and pathological characterization of the associated lesions, were performed. Our results revealed 1) the existence of at least two distinct TeHV3 genogroups apparently associated with different pathologies in tortoises and 2) the first evidence for a putative homologous recombination event having occurred in a chelonian herpesvirus. This novel information is not only fundamental for the genetic characterization of this virus but is also critical to lay the groundwork for an improved understanding of host-pathogen interactions in chelonians and contribute to tortoise conservation.

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Herpesvirus-like infection in two young boas

Cited by 25 publications

References 1 publication

Viruses Infecting Reptiles

Viruses Infecting Reptiles

Viruses of Lower Vertebrates

A Genomic Approach to Unravel Host-Pathogen Interaction in Chelonians: The Example of Testudinid Herpesvirus 3

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